KEGG   ENZYME: 4.2.3.190
Entry
EC 4.2.3.190                Enzyme                                 
Name
manoyl oxide synthase;
GrTPS6;
CfTPS3;
CfTPS4;
MvELS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate diphosphate-lyase (manoyl-oxide-forming)
Reaction(IUBMB)
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = manoyl oxide + diphosphate [RN:R11857]
Reaction(KEGG)
R11857
Substrate
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate [CPD:C20270]
Product
manoyl oxide [CPD:C21725];
diphosphate [CPD:C00013]
Comment
Manoyl oxide is found in many plants. This enzyme has been isolated from the plants, Grindelia hirsutula (gum weed), Plectranthus barbatus (forskohlii) and Marrubium vulgare (white horehound).
History
EC 4.2.3.190 created 2017
Reference
1  [PMID:23613273]
  Authors
Zerbe P, Hamberger B, Yuen MM, Chiang A, Sandhu HK, Madilao LL, Nguyen A, Hamberger B, Bach SS, Bohlmann J
  Title
Gene discovery of modular diterpene metabolism in nonmodel systems.
  Journal
Plant Physiol 162:1073-91 (2013)
DOI:10.1104/pp.113.218347
Reference
2  [PMID:24481136]
  Authors
Pateraki I, Andersen-Ranberg J, Hamberger B, Heskes AM, Martens HJ, Zerbe P, Bach SS, Moller BL, Bohlmann J, Hamberger B
  Title
Manoyl oxide (13R), the biosynthetic precursor of forskolin, is synthesized in specialized root cork cells in Coleus forskohlii.
  Journal
Plant Physiol 164:1222-36 (2014)
DOI:10.1104/pp.113.228429
  Sequence
[ag:AHW04048]
Reference
3  [PMID:24990389]
  Authors
Zerbe P, Chiang A, Dullat H, O'Neil-Johnson M, Starks C, Hamberger B, Bohlmann J
  Title
Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare.
  Journal
Plant J 79:914-27 (2014)
DOI:10.1111/tpj.12589
  Sequence
[ag:AIE77094]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.190
IUBMB Enzyme Nomenclature: 4.2.3.190
ExPASy - ENZYME nomenclature database: 4.2.3.190
BRENDA, the Enzyme Database: 4.2.3.190

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (6)   
   InterPro (6)   
All databases (13)   

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