KEGG   ENZYME: 4.2.3.191
Entry
EC 4.2.3.191                Enzyme                                 
Name
cycloaraneosene synthase;
SdnA
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cycloaraneosene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = cycloaraneosene + diphosphate [RN:R11858]
Reaction(KEGG)
R11858
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
cycloaraneosene [CPD:C21726];
diphosphate [CPD:C00013]
Comment
Isolated from the fungus Sordaria araneosa. Cycloaraneosene is a precursor of the antibiotic sordarin.
History
EC 4.2.3.191 created 2017
Orthology
K22542  cycloaraneosene synthase
Genes
ELAUCREL1_7390
Reference
1  [PMID:27072286]
  Authors
Kudo F, Matsuura Y, Hayashi T, Fukushima M, Eguchi T
  Title
Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase.
  Journal
J Antibiot (Tokyo) 69:541-8 (2016)
DOI:10.1038/ja.2016.40
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.191
IUBMB Enzyme Nomenclature: 4.2.3.191
ExPASy - ENZYME nomenclature database: 4.2.3.191
BRENDA, the Enzyme Database: 4.2.3.191

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