KEGG   ENZYME: 4.2.3.194
Entry
EC 4.2.3.194                Enzyme                                 
Name
(-)-drimenol synthase;
PhDS;
VoTPS3;
farnesyl pyrophosphate:drimenol cyclase;
drimenol cyclase;
(2E,6E)-farnesyl-diphosphate diphosphohydrolase (drimenol-forming)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphospho-lyase [cyclising, (-)-drimenol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (-)-drimenol + diphosphate [RN:R09628]
Reaction(KEGG)
R09628
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(-)-drimenol [CPD:C19743];
diphosphate [CPD:C00013]
Comment
Isolated from the plants Valeriana officinalis (valerian) and Persicaria hydropiper (water pepper). The enzyme does not act on farnesol or drimenol diphosphate. Using 18-oxygen labelled water 18-oxygen was incorporated suggesting involvement of a stabilised carbocation or an equivalent species.
History
EC 4.2.3.194 created 2011 as EC 3.1.7.7, transferred 2017 to EC 4.2.3.194
Orthology
K22967  (-)-drimenol synthase
Reference
1
  Authors
Banthorp, D.V., Brown, J.T. and Morris, G.S.
  Title
Partial purification of farnesyl pyrophosphate:drimenol cyclase and geranylgerany pyrophosphate:sclareol cyclase, using cell culture as a source of material.
  Journal
Phytochemistry 31:3391-3395 (1992)
Reference
2  [PMID:25447532]
  Authors
Kwon M, Cochrane SA, Vederas JC, Ro DK
  Title
Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis).
  Journal
FEBS Lett 588:4597-603 (2014)
DOI:10.1016/j.febslet.2014.10.031
  Sequence
[ag:AFR42419]
Reference
3  [PMID:28258968]
  Authors
Henquet MGL, Prota N, van der Hooft JJJ, Varbanova-Herde M, Hulzink RJM, de Vos M, Prins M, de Both MTJ, Franssen MCR, Bouwmeester H, Jongsma M
  Title
Identification of a drimenol synthase and drimenol oxidase from Persicaria hydropiper, involved in the biosynthesis of insect deterrent drimanes.
  Journal
Plant J 90:1052-1063 (2017)
DOI:10.1111/tpj.13527
  Sequence
[ag:AHF22834]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.194
IUBMB Enzyme Nomenclature: 4.2.3.194
ExPASy - ENZYME nomenclature database: 4.2.3.194
BRENDA, the Enzyme Database: 4.2.3.194
CAS: 146838-17-7

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (8)   
   UniProt (3)   
   SWISS-PROT (3)   
   PDBSTR (2)   
3D Structure (1)   
   PDB (1)   
Protein domain (10)   
   InterPro (10)   
All databases (27)   

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