KEGG   ENZYME: 4.2.3.203
Entry
EC 4.2.3.203                Enzyme                                 
Name
isoelisabethatriene synthase;
HpS (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, isoelisabethatriene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = isoelisabethatriene + diphosphate [RN:R12365]
Reaction(KEGG)
R12365
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
isoelisabethatriene [CPD:C22110];
diphosphate [CPD:C00013]
Comment
Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is involved in a 1,3-hydride shift to the side-chain. The enzyme also produces hydropyrene, hydropyrenol, and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.202, hydropyrenol synthase.
History
EC 4.2.3.203 created 2019
Orthology
K23530  hydropyrene/hydropyrenol/isoelisabethatriene synthase
Genes
SCLF: BB341_28045
Reference
1  [PMID:28696553]
  Authors
Rinkel J, Rabe P, Chen X, Kollner TG, Chen F, Dickschat JS
  Title
Mechanisms of the Diterpene Cyclases beta-Pinacene Synthase from Dictyostelium discoideum and Hydropyrene Synthase from Streptomyces clavuligerus.
  Journal
Chemistry 23:10501-10505 (2017)
DOI:10.1002/chem.201702704
  Sequence
[sclf:BB341_28045]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.203
IUBMB Enzyme Nomenclature: 4.2.3.203
ExPASy - ENZYME nomenclature database: 4.2.3.203
BRENDA, the Enzyme Database: 4.2.3.203

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (6)   

Download RDF
DBGET integrated database retrieval system