KEGG   ENZYME: 4.2.3.211
Entry
EC 4.2.3.211                Enzyme                                 
Name
(+)-exo-beta-bergamotene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-exo-beta-bergamotene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-exo-beta-bergamotene + diphosphate [RN:R13104]
Reaction(KEGG)
R13104
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-exo-beta-bergamotene [CPD:C22617];
diphosphate [CPD:C00013]
Comment
The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin.
History
EC 4.2.3.211 created 2022
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22569  (+)-exo-beta-bergamotene synthase
Genes
MAJ: MAA_08344
AFM: AFUA_8G00520
Reference
1  [PMID:23488861]
  Authors
Lin HC, Chooi YH, Dhingra S, Xu W, Calvo AM, Tang Y.
  Title
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of beta-trans-bergamotene.
  Journal
J Am Chem Soc 135:4616-9 (2013)
DOI:10.1021/ja312503y
  Sequence
[afm:AFUA_8G00520]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.211
IUBMB Enzyme Nomenclature: 4.2.3.211
ExPASy - ENZYME nomenclature database: 4.2.3.211
BRENDA, the Enzyme Database: 4.2.3.211

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (19)   

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