KEGG   ENZYME: 4.2.3.212
Entry
EC 4.2.3.212                Enzyme                                 
Name
(+)-delta-cadinol synthase;
delta-cadinol synthase (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-delta-cadinol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (+)-delta-cadinol + diphosphate [RN:R13226]
Reaction(KEGG)
R13226
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(+)-delta-cadinol [CPD:C22837];
diphosphate [CPD:C00013]
Comment
The enzyme is involved in the biosynthesis of sesquiterpenoids from (2E,6E)-farnesyl diphosphate in fungi such as Boreostereum vibrans and Coniophora puteana.
History
EC 4.2.3.212 created 2023
Orthology
K21927  alpha-muurolene/germacrene-A/gamma-muurolene/(+)-delta-cadinol synthase
K27202  (+)-delta-cadinol synthase
Genes
DFR: 124500479
TVS: TRAVEDRAFT_125681 TRAVEDRAFT_75578
DSQ: DICSQDRAFT_124305 DICSQDRAFT_144469
SHS: STEHIDRAFT_167646 STEHIDRAFT_45387
HIR: HETIRDRAFT_167573 HETIRDRAFT_382802
FME: FOMMEDRAFT_109318
GTR: GLOTRDRAFT_103889
CCI: CC1G_10050 CC1G_12294
ABP: AGABI1DRAFT46681(AGABI1DRAFT_46681) AGABI1DRAFT76352(AGABI1DRAFT_76352)
ABV: AGABI2DRAFT183802(AGABI2DRAFT_183802) AGABI2DRAFT73543(AGABI2DRAFT_73543)
PCUB: JR316_0003914
MPR: MPER_06109
MRR: Moror_15644 Moror_7733
MORE: E1B28_009287(COP3)
CPUT: CONPUDRAFT_118913 CONPUDRAFT_50941
SLA: SERLADRAFT_356263(cyc2) SERLADRAFT_370008(cyc3)
 » show all
Reference
1  [PMID:27038475]
  Authors
Zhou H, Yang YL, Zeng J, Zhang L, Ding ZH, Zeng Y.
  Title
Identification and Characterization of a delta-Cadinol Synthase Potentially Involved in the Formation of Boreovibrins in Boreostereum vibrans of Basidiomycota.
  Journal
Nat Prod Bioprospect 6:167-71 (2016)
DOI:10.1007/s13659-016-0096-4
  Sequence
[ag:AMW90891]
Reference
2  [PMID:35440053]
  Authors
Ringel M, Dimos N, Himpich S, Haack M, Huber C, Eisenreich W, Schenk G, Loll B, Bruck T.
  Title
Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of delta-cadinol.
  Journal
Microb Cell Fact 21:64 (2022)
DOI:10.1186/s12934-022-01791-8
  Sequence
[cput:CONPUDRAFT_50941 CONPUDRAFT_118913]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.212
IUBMB Enzyme Nomenclature: 4.2.3.212
ExPASy - ENZYME nomenclature database: 4.2.3.212
BRENDA, the Enzyme Database: 4.2.3.212

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (29)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (27)   
All databases (34)   

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