ENZYME: 4.2.3.220
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Entry
EC 4.2.3.220 Enzyme
Name
talaropentaene synthase;
TvTS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
pentaprenyl-diphosphate diphosphate-lyase [cyclizing, talaropentaene-forming]
Reaction(IUBMB)
all-trans-hexaprenyl diphosphate = talaropentaene + diphosphate
Substrate
all-trans-hexaprenyl diphosphate [CPD:
C01230
]
Product
talaropentaene;
diphosphate [CPD:
C00013
]
Comment
Isolated from the fungus Talaromyces verruculosus.
History
EC 4.2.3.220 created 2024
Reference
1 [PMID:
35650436
]
Authors
Tao H, Lauterbach L, Bian G, Chen R, Hou A, Mori T, Cheng S, Hu B, Lu L, Mu X, Li M, Adachi N, Kawasaki M, Moriya T, Senda T, Wang X, Deng Z, Abe I, Dickschat JS, Liu T.
Title
Discovery of non-squalene triterpenes.
Journal
Nature 606:414-419 (2022)
DOI:
10.1038/s41586-022-04773-3
Sequence
[ag:
KUL85185
]
Other DBs
ExplorEnz - The Enzyme Database:
4.2.3.220
IUBMB Enzyme Nomenclature:
4.2.3.220
ExPASy - ENZYME nomenclature database:
4.2.3.220
BRENDA, the Enzyme Database:
4.2.3.220
All links
Chemical substance (2)
KEGG COMPOUND (2)
All databases (2)
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