KEGG   ENZYME: 4.2.3.55
Entry
EC 4.2.3.55                 Enzyme                                 
Name
(S)-beta-bisabolene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(S)-beta-bisabolene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate [RN:R09623]
Reaction(KEGG)
R09623
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(S)-beta-bisabolene [CPD:C16775];
diphosphate [CPD:C00013]
Comment
The synthesis of (S)-beta-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-beta-bisabolene. The second step is the isomerization to (S)-beta-macrocarpene (cf. EC 5.5.1.17, (S)-beta-macrocarpene synthase). The enzyme requires Mg2+ or Mn2+ for activity.
History
EC 4.2.3.55 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15794  (S)-beta-bisabolene synthase
Reference
1  [PMID:20229191]
  Authors
Fujisawa M, Harada H, Kenmoku H, Mizutani S, Misawa N
  Title
Cloning and characterization of a novel gene that encodes (S)-beta-bisabolene synthase from ginger, Zingiber officinale.
  Journal
Planta 232:121-30 (2010)
DOI:10.1007/s00425-010-1137-6
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.55
IUBMB Enzyme Nomenclature: 4.2.3.55
ExPASy - ENZYME nomenclature database: 4.2.3.55
BRENDA, the Enzyme Database: 4.2.3.55

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