Entry |
|
Name |
trichodiene synthase;
trichodiene synthetase;
sesquiterpene cyclase;
trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase
|
Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
|
Sysname |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)
|
Reaction(IUBMB) |
(2E,6E)-farnesyl diphosphate = trichodiene + diphosphate [RN: R02306]
|
Reaction(KEGG) |
|
Substrate |
(2E,6E)-farnesyl diphosphate [CPD: C00448]
|
Product |
|
History |
EC 4.2.3.6 created 1989 as EC 4.1.99.6, transferred 2000 to EC 4.2.3.6
|
Pathway |
ec00909 | Sesquiterpenoid and triterpenoid biosynthesis |
|
Orthology |
|
Genes |
FPOA: | FPOAC1_005923(TRI5) |
AMUS: | LMH87_000337 LMH87_003972 | » show all
|
Reference |
|
Authors |
Hohn TM, Vanmiddlesworth F. |
Title |
Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides. |
Journal |
|
Reference |
|
Authors |
Hohn TM, Beremand PD |
Title |
Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Rynkiewicz MJ, Cane DE, Christianson DW |
Title |
Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 4.2.3.6 |
ExPASy - ENZYME nomenclature database: | 4.2.3.6 |
BRENDA, the Enzyme Database: | 4.2.3.6 |
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