KEGG   ENZYME: 4.2.3.6
Entry
EC 4.2.3.6                  Enzyme                                 
Name
trichodiene synthase;
trichodiene synthetase;
sesquiterpene cyclase;
trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = trichodiene + diphosphate [RN:R02306]
Reaction(KEGG)
R02306
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
trichodiene [CPD:C01860];
diphosphate [CPD:C00013]
History
EC 4.2.3.6 created 1989 as EC 4.1.99.6, transferred 2000 to EC 4.2.3.6
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K12249  trichodiene synthase
Genes
FGRFGSG_03537
FPUFPSE_12160(TRI5)
FPOAFPOAC1_005923(TRI5)
FVNFVRRES_06532
NHENECHADRAFT_97884
FFCNCS54_01458300
FKRNCS57_01441900
AMUSLMH87_000337 LMH87_003972
CLUPCLUP02_13045
NFINFIA_042070
AORAO090026000382
AFVAFLA_005899
BCOMBAUCODRAFT_27945
 » show all
Reference
1  [PMID:3800398]
  Authors
Hohn TM, Vanmiddlesworth F.
  Title
Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides.
  Journal
Arch Biochem Biophys 251:756-61 (1986)
DOI:10.1016/0003-9861(86)90386-3
Reference
2  [PMID:2777086]
  Authors
Hohn TM, Beremand PD
  Title
Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides.
  Journal
Gene 79:131-8 (1989)
DOI:10.1016/0378-1119(89)90098-X
  Sequence
Reference
3  [PMID:11698643]
  Authors
Rynkiewicz MJ, Cane DE, Christianson DW
  Title
Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade.
  Journal
Proc Natl Acad Sci U S A 98:13543-8 (2001)
DOI:10.1073/pnas.231313098
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.6
IUBMB Enzyme Nomenclature: 4.2.3.6
ExPASy - ENZYME nomenclature database: 4.2.3.6
BRENDA, the Enzyme Database: 4.2.3.6
CAS: 101915-76-8

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