Requires Mg2+. In the bacteria Streptomyces and the liverwort Heteroscyphus the (+)-isomer is formed in contrast to higher plants where the (-)-isomer is formed.
History
EC 4.2.3.64 created 2011
Reference
1
Authors
Cane, D.E., Tandon, M., and Prabhakaran, P.C.
Title
Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate.
Journal
J Am Chem Soc 115:8103-8106 (1993)
Reference
2
Authors
Cane, D.E. and Tandon, M.
Title
Biosynthesis of (+)-epicubenol.
Journal
Tetrahedron Lett 35:5355-5358 (1994)
Reference
3
Authors
Cane, D.E. and Tandon, M.
Title
Epicubenol synthase and the stereochemistry of the enzymatic cyclization of farnesyl and nerolidyl diphosphate.
Journal
J Am Chem Soc 117:5602-5603 (1995)
Reference
4
Authors
Nabeta, K., Kigure, K., Fujita, M., Nagoya, T., Ishikawa, T., Okuyama, H. and Takasawa, T.
Title
Bioynthesis of (+)-cubenene and (+)-epicubenol by cell-free extracts of cultured cells of Heteroscyphus planus and cyclization of [2H]farnesyl diphosphates.
Journal
J Chem Soc, Perkin Trans 1 1935-1939 (1995)
Reference
5
Authors
Nabeta, K., Fujita, M., Komuro, K., Katayama, K., and Takasawa, T.
Title
In vitro biosynthesis of cadinanes by cell-free extracts of cultured cells of Heteroscyphus planus.