KEGG   ENZYME: 4.2.3.69
Entry
EC 4.2.3.69                 Enzyme                                 
Name
(+)-alpha-barbatene synthase;
AtBS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-alpha-barbatene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate [RN:R09614]
Reaction(KEGG)
R09614
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-alpha-barbatene [CPD:C19740];
diphosphate [CPD:C00013]
Comment
The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% alpha-barbatene, 17.8% thujopsene (cf. EC 4.2.3.79, thujopsene synthase) and 9.9% beta-chamigrene (cf. EC 4.2.3.78, beta-chamigrene synthase) [1] plus traces of other sesquiterpenoids [2].
History
EC 4.2.3.69 created 2011, modified 2012
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15799  (+)-alpha-barbatene/beta-chamigrene/thujopsene synthase
Genes
ATH: AT5G44630
CRB: 17875170 17875197 17876640
CSAT: 104771640
EUS: EUTSA_v10001108mg EUTSA_v10001148mg EUTSA_v10001228mg
BRP: 103845828 103848456 103863851
BNA: 106371933 106449519
BOE: 106316964 106325935
RSZ: 108809961 108835137 108851518
Reference
1  [PMID:15965019]
  Authors
Wu S, Schoenbeck MA, Greenhagen BT, Takahashi S, Lee S, Coates RM, Chappell J
  Title
Surrogate splicing for functional analysis of sesquiterpene synthase genes.
  Journal
Plant Physiol 138:1322-33 (2005)
DOI:10.1104/pp.105.059386
  Sequence
[ath:AT5G44630]
Reference
2  [PMID:15918888]
  Authors
Tholl D, Chen F, Petri J, Gershenzon J, Pichersky E
  Title
Two sesquiterpene synthases are responsible for the complex mixture of sesquiterpenes emitted from Arabidopsis flowers.
  Journal
Plant J 42:757-71 (2005)
DOI:10.1111/j.1365-313X.2005.02417.x
  Sequence
[ath:AT5G44630]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.69
IUBMB Enzyme Nomenclature: 4.2.3.69
ExPASy - ENZYME nomenclature database: 4.2.3.69
BRENDA, the Enzyme Database: 4.2.3.69

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (18)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (7)   
   InterPro (7)   
All databases (35)   

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