Entry
Name
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-alpha-gurjunene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate [RN:
R09606 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448 ]
Product
Comment
Initial cyclization probably gives biyclogermacrene in an enzyme bound form which is not released to the medium. The enzyme from Solidago canadensis also forms a small amount of (+)-gamma-gurjunene [1].
History
EC 4.2.3.72 created 2011
Reference
Authors
Schmidt CO, Bouwmeester HJ, Bulow N, Konig WA
Title
Isolation, characterization, and mechanistic studies of (-)-alpha-gurjunene synthase from Solidago canadensis.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.72
ExPASy - ENZYME nomenclature database: 4.2.3.72