KEGG   ENZYME: 4.2.3.82
Entry
EC 4.2.3.82                 Enzyme                                 
Name
alpha-santalene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl diphosphate lyase (cyclizing, (+)-alpha-santalene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate [RN:R10733]
Reaction(KEGG)
R10733
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-alpha-santalene [CPD:C19736];
diphosphate [CPD:C00013]
Comment
The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (+)-alpha-santalene, (-)-beta-santalene and (-)-exo-alpha-bergamotene are formed with traces of (+)-epi-beta-santalene. See EC 4.2.3.83 [(-)-beta-santalene synthase], and EC 4.2.3.81 [(-)-exo-alpha-bergamotene synthase]. cf. EC 4.2.3.50 alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
History
EC 4.2.3.82 created 2011
Orthology
K22035  alpha/beta-santalene synthase
Reference
1  [PMID:21454632]
  Authors
Jones CG, Moniodis J, Zulak KG, Scaffidi A, Plummer JA, Ghisalberti EL, Barbour EL, Bohlmann J
  Title
Sandalwood fragrance biosynthesis involves sesquiterpene synthases of both the terpene synthase (TPS)-a and TPS-b subfamilies, including santalene synthases.
  Journal
J Biol Chem 286:17445-54 (2011)
DOI:10.1074/jbc.M111.231787
  Sequence
[ag:ADO87000 ADO87001 ADO87002]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.82
IUBMB Enzyme Nomenclature: 4.2.3.82
ExPASy - ENZYME nomenclature database: 4.2.3.82
BRENDA, the Enzyme Database: 4.2.3.82

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (3)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (3)   
Protein domain (7)   
   InterPro (7)   
All databases (22)   

Download RDF
DBGET integrated database retrieval system