Entry
Name
(+)-beta-caryophyllene synthase;
GcoA
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2Z,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-beta-caryophyllene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-beta-caryophyllene + diphosphate [RN:
R09889 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448 ]
Product
(+)-beta-caryophyllene [CPD:
C19973 ];
diphosphate [CPD:
C00013 ]
Comment
A multifunctional enzyme which also converts the (+)-beta-caryophyllene to (+)-caryolan-1-ol (see EC
4.2.1.138 , (+)-caryolan-1-ol synthase). cf. EC
4.2.3.57 (-)-beta-caryophyllene synthase.
History
EC 4.2.3.89 created 2011
Pathway
ec00909 Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K18111 (+)-beta-caryophyllene/(+)-caryolan-1-ol synthase
Genes
NTC : KHQ06_23155 KHQ06_27360 KHQ06_31745
» show all
Taxonomy
Reference
Authors
Nakano C, Horinouchi S, Ohnishi Y
Title
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.89
ExPASy - ENZYME nomenclature database: 4.2.3.89