KEGG   ENZYME: 4.2.3.89
Entry
EC 4.2.3.89                 Enzyme                                 
Name
(+)-beta-caryophyllene synthase;
GcoA
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2Z,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-beta-caryophyllene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-beta-caryophyllene + diphosphate [RN:R09889]
Reaction(KEGG)
R09889
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-beta-caryophyllene [CPD:C19973];
diphosphate [CPD:C00013]
Comment
A multifunctional enzyme which also converts the (+)-beta-caryophyllene to (+)-caryolan-1-ol (see EC 4.2.1.138, (+)-caryolan-1-ol synthase). cf. EC 4.2.3.57 (-)-beta-caryophyllene synthase.
History
EC 4.2.3.89 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K18111  (+)-beta-caryophyllene/(+)-caryolan-1-ol synthase
Genes
NTCKHQ06_23155 KHQ06_27360 KHQ06_31745
SGRSGR_2079
SGBWQO_25120
SFISFUL_5260
SANLKZO11_26645
SGRFSGFS_066400
SCYER2B67_09240
SSXSACTE_4655
SCZABE83_10275
SVUB1H20_25705
SQZFQU76_14935
SNKCP967_09635
SRKFGW37_32260
SCAVCVT27_24400
SCYGS1361_14270(gcoA)
SCALI6J39_25390
STRYEQG64_25440
SINEKI385_28650
SDRZNEH16_09235
SFIYF0344_09530
SLAIP8A22_11320
KABB7C62_26245
 » show all
Reference
1  [PMID:21693706]
  Authors
Nakano C, Horinouchi S, Ohnishi Y
  Title
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus.
  Journal
J Biol Chem 286:27980-7 (2011)
DOI:10.1074/jbc.M111.265652
  Sequence
[sgr:SGR_2079]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.89
IUBMB Enzyme Nomenclature: 4.2.3.89
ExPASy - ENZYME nomenclature database: 4.2.3.89
BRENDA, the Enzyme Database: 4.2.3.89

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