Entry
Name
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, cubebol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate [RN:
R09891 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires Mg2+. The enzyme gives 28% cubebol, 29% (-)-germacrene D, 10% (+)-delta-cadinene and traces of several other sesquiterpenoids. See also EC
4.2.3.75 (-)-germacrene D synthase and EC
4.2.3.13 (+)-delta-cadinene synthase.
History
EC 4.2.3.91 created 2011
Orthology
K22058 cubebol/beta-copaene/beta-cubebene/(+)-sativene synthase
Genes
Taxonomy
Reference
Authors
Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C
Title
Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.91
ExPASy - ENZYME nomenclature database: 4.2.3.91