KEGG ENZYME: 4.2.3.97

ENZYME: 4.2.3.97

Entry

EC 4.2.3.97                 Enzyme

Name

(-)-delta-cadinene synthase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-delta-cadinene-forming)

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate [RN:R09897]

Reaction(KEGG)

R09897

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

(-)-delta-cadinene [CPD:C20182];
diphosphate [CPD:C00013]

Comment

The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. Following a 1,3-hydride shift of the original 1-pro-S hydrogen of (2E,6E)-farnesyl diphosphate, cyclization and deprotonation gives (-)-delta-cadinene.

History

EC 4.2.3.97 created 2012

Orthology

K21978

(-)-delta-cadinene synthase

Reference

1 [PMID:21276937]

Authors

Hu Y, Chou WK, Hopson R, Cane DE

Title

Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases.

Journal