KEGG   ENZYME: 4.2.3.99
Entry
EC 4.2.3.99                 Enzyme                                 
Name
labdatriene synthase;
OsKSL10 (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
9alpha-copalyl-diphosphate diphosphate-lyase [(12E)-9alpha-labda-8(17),12,14-triene-forming]
Reaction(IUBMB)
9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate [RN:R09899]
Reaction(KEGG)
R09899
Substrate
9alpha-copalyl diphosphate [CPD:C11902]
Product
(12E)-9alpha-labda-8(17),12,14-triene [CPD:C20185];
diphosphate [CPD:C00013]
Comment
The enzyme from rice (Oryza sativa), expressed in Escherichia coli, also produces ent-sandaracopimara-8(14),15-diene from ent-copalyl diphosphate, another naturally occuring copalyl isomer in rice (cf. ent-sandaracopimaradiene synthase, EC 4.2.3.29).
History
EC 4.2.3.99 created 2012
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14037  ent-sandaracopimaradiene/labdatriene synthase
Genes
OSA4352248
DOSAOs12t0491800-01(Os12g0491800)
OGL127756329 127757831
Reference
1  [PMID:21323642]
  Authors
Morrone D, Hillwig ML, Mead ME, Lowry L, Fulton DB, Peters RJ
  Title
Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals.
  Journal
Biochem J 435:589-95 (2011)
DOI:10.1042/BJ20101429
  Sequence
[osa:4352248]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.99
IUBMB Enzyme Nomenclature: 4.2.3.99
ExPASy - ENZYME nomenclature database: 4.2.3.99
BRENDA, the Enzyme Database: 4.2.3.99

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