KEGG ENZYME: 4.3.1.14

ENZYME: 4.3.1.14

Entry

EC 4.3.1.14                 Enzyme

Name

3-aminobutyryl-CoA ammonia-lyase;
L-3-aminobutyryl-CoA deaminase;
L-3-aminobutyryl-CoA ammonia-lyase

Class

Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases

Sysname

L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)

Reaction(IUBMB)

L-3-aminobutyryl-CoA = crotonoyl-CoA + NH3 [RN:R03030]

Reaction(KEGG)

R03030

Substrate

L-3-aminobutyryl-CoA [CPD:C05231]

Product

crotonoyl-CoA [CPD:C00877];
NH3 [CPD:C00014]

Comment

Hydroxylamine can replace ammonia as a substrate. Crotonoyl-pantetheine can replace crotonoyl-CoA but it is a poorer substrate.

History

EC 4.3.1.14 created 1999

Pathway

ec00310

Lysine degradation

ec01100

Metabolic pathways

Orthology

K18014

3-aminobutyryl-CoA ammonia-lyase

Genes

PUS:	CKA81_12900

RFR:

Rfer_3886

NOK:	FAY22_04150

ARES:

IWH25_08680

APET:

ToN1_41390

AZA:

AZKH_1578

AZI:	AzCIB_1070

SVC:	STVA_53550

DEK:	DSLASN_49380(kal)

ADE:

Adeh_1486

ACP:	A2cp1_2469

AFW:	Anae109_2346

ANK:	AnaeK_2381

AORY:

AMOR_53310(kal)

APAU:

AMPC_09770(kal)

MXA:

MXAN_4385

MSD:	MYSTI_04874

MYM:	A176_002518

MFB:	MFUL124B02_26675

MYX:	QEG98_23515

CCX:	COCOR_03528

MFU:	LILAB_30015

MMAS:

MYMAC_004299

SUR:	STAUR_4745

AGE:	AA314_04549

AVM:	JQX13_36725

MBD:	MEBOL_007832

VIN:	AKJ08_2030

BSED:

DN745_10920

PCAY:

FRD00_15180

BBAE:

FRD01_09525

AFX:	JZ786_00695

ACUR:

JZ785_19585

ACYC:

JI721_05805

TUM:	CBW65_05390

TAB:	CIG75_01725

LFB:	C1X05_16285

TVU:	AB849_005245

KPUL:

GXN76_15670

KEB:	GXN75_17005

PABS:

JIR001_30740(kal)

CTC:	CTC_00606 CTC_02085 CTC_02086

CTET:

BN906_00630 BN906_02286 BN906_02287(kal_2)

CBN:	CbC4_0397 CbC4_0398

CLS:	CXIVA_06670

CPAT:

CLPA_c31510(kal)

CPAE:

CPAST_c31510(kal)

CSQ:	CSCA_1551 CSCA_1552

CCK:	Ccar_06920 Ccar_06925 Ccar_23765 Ccar_23770

CEU:	A7L45_04270

CCHV:

BTM20_08305 BTM20_08310

CARG:

RSJ17_19920

CDRK:

B9W14_11515 B9W14_11520

CSEP:

CP523_14780 CP523_14785

CCOH:

SAMEA4530647_0507 SAMEA4530647_0508 SAMEA4530647_1851 SAMEA4530647_1852

CFER:

D4Z93_08140 D4Z93_08145 D4Z93_08150

CRW:	CROST_000160(kal)

CFB:	CLFE_002840(kal)

CAUN:

CLAUR_029790(kal)

CTAG:

LL095_01340

CALD:

PWK10_03565

CRS:	FQB35_13740

CPRF:

K7H06_00145

CRAS:

KVH43_03190

OCW:	OW730_07260

PROQ:

P6M73_04595

FPLA:

A4U99_05315 A4U99_11310

PFAA:

MM59RIKEN_10260 MM59RIKEN_18360

VFA:	MM35RIKEN_07370(kal)

VCOP:

MM50RIKEN_12240(kal)

STH:

STH63

DAI:	Desaci_1865

AACX:

DEACI_2075

ACAE:

HYG86_10525

IBU:	IB211_00976

PROM:

QO263_00495

EUU:	ADJ67_02620

BPRL:

CL2_22180 CL2_22190 CL2_22290

ARF:	AR1Y2_3399 AR1Y2_3400

ACAC:

EYQ97_00795 EYQ97_00800

LUA:	D4A81_03610

LGG:	QJR73_02600 QJR73_02885

EHL:	EHLA_1857 EHLA_1858

CPRO:

CPRO_06750(kal_1) CPRO_16260(kal_2) CPRO_21580(kal_3) CPRO_21590(kal_4)

ANV:	RBQ60_06050 RBQ60_06055 RBQ60_06065 RBQ60_06070 RBQ60_06240 RBQ60_11665

VGU:	HYG85_18510

VPY:	HZI73_18020

AMIJ:

EQM06_11675

AMIC:

Ami3637_09120

ABUT:

Ami103574_15025

ETM:	CE91St48_07350(kal)

AMT:

Amet_0317

AOE:

Clos_2598

GFE:	Gferi_11200

CSPO:

QNI18_05565

TEM:	JW646_01955 JW646_01960 JW646_07185

TGC:	L0P85_01285 L0P85_06225 L0P85_06230

TMY:	TEMA_03260(kal_1) TEMA_03270(kal_2)

TEB:	T8CH_2407(kal)

THYR:

P4S50_05120

PEB:	O0R46_01415 O0R46_01420

CST:	CLOST_1385(kal)

TTE:

TTE0718

TWI:	Thewi_0849

NTH:	Nther_1882

HPK:	Hprae_1558

HALS:

D7D81_18050

IFN:	GM661_14615

AFT:	BBF96_12055

HPRF:

HLPR_25940

AMEI:

LV469_06380

SPOA:

EQM13_03150

KPAR:

JL105_08400

CAZO:

G3A45_10610

TIZ:	RBU61_15230

SEDZ:

JYG23_14270

PUF:

UFO1_1642

PFT:

JBW_02723

FCZ:	IMF26_07420

MANR:

MPAN_016030(kal)

MBJ:	KQ51_00860(kal)

XCL:	G4Z02_00835

TBK:	HF295_06565

TBM:	BK010_00730

TBZ:	BK011_00630

MPHL:

MPHLCCUG_04684(kal)

NFR:	ERS450000_00652

NCY:	NOCYR_3011

NAD:	NCTC11293_03485

NHU:	H0264_26270

RHA:	RHA1_ro05324

ROP:

ROP_36710

ROA:	Pd630_LPD04266

RAV:	AAT18_13600

RKO:	JWS14_20695 JWS14_45620

ROZ:	CBI38_11850

RPSK:

JWS13_26705

TSD:	MTP03_33740(kal)

SVT:	SVTN_37435

SCYA:

EJ357_39475

SCIN:

CP977_30445

SPEU:

CGZ69_32325

STRY:

EQG64_12900

AAU:	AAur_pTC10059

ICA:	Intca_1793

ARS:	ADJ73_12500

TEH:	GKE56_04795

PEI:	H9L10_06025

TED:	U5C87_14730

SERW:

FY030_07850

ORN:	DV701_02945

OCP:	NF557_08910

RAIN:

Rai3103_14395

NCA:

Noca_2665

NOY:	EXE57_02170

NOI:	FCL41_08540

NOO:	FE634_10530

NDP:	E2C04_09140

NSN:	EXE58_17590

NANO:

G5V58_11095

NMES:

H9L09_20175

NPI:	G7071_14770

NAQU:

ENKNEFLB_02383(kal)

NRO:	K8W59_08660

NOQ:	LN652_02055

NCQ:	K6T13_09135

NPS:	KRR39_08660

KFL:

Kfla_3600

KSL:	OG809_32745

TCU:

Tcur_2348

AGRA:

AGRA3207_000440

AMAZ:

LUW76_03350

ACIR:

OG979_38045

SPIQ:

OHA34_02750

ACTQ:

OG417_28740

BLAP:

MVA48_03885

MMAR:

MODMU_2633

AOI:

AORI_4736

AJA:	AJAP_28630

AROO:

NQK81_11580

APRE:

CNX65_17225

AMI:

Amir_3398

SESP:

BN6_43160

SSYI:

EKG83_24025

KAL:

KALB_4417

KUT:	JJ691_26840(kal)

KPHY:

AOZ06_27980

LED:	BBK82_41110

ALO:

CRK56466

ACTU:

Actkin_03092(kal)

CROS:

N8J89_23650

STP:	Strop_2267

SAQ:

Sare_2386

MAU:	Micau_3124

MIL:

ML5_5271

MICB:

MicB006_2178

MTUA:

CSH63_09495

MICH:

FJK98_17885

MTEM:

GCE86_10840

MCAB:

HXZ27_19845

MSAG:

GCM10017556_54760

VMA:	VAB18032_20390 VAB18032_22295

VER:	HUT12_17890

MENO:

Jiend_59950

MCHL:

PVK74_05890

MFEU:

H1D33_20985

MPRN:

Q3V37_21645

MHAW:

RMN56_27185

ASE:

ACPL_2801

AMS:	AMIS_47580

ACTN:

L083_3929

AFS:

AFR_21800

ACTS:

ACWT_2745

AIH:	Aiant_75480

ACTR:

Asp14428_06260

ACTL:

L3i22_031840

ASIC:

Q0Z83_010270

AOU:	ACTOB_002932

PLK:	CIK06_14150

PLAB:

C6361_03365

PLAT:

C6W10_18260

PFLA:

Pflav_024660

PSUU:

Psuf_079170

ATL:	Athai_29160

ASER:

Asera_45380

PRY:	Prubr_60580(kal)

CATI:

CS0771_51120

DVC:	Dvina_27765

DFU:	Dfulv_24935

DROS:

Drose_20000

DAUR:

Daura_26285

DMAT:

Dmats_23090

NHY:	JQS43_13145

CCAZ:

COUCH_20875

SNA:

Snas_3948

NAV:	JQS30_07350

GLY:	K3N28_19450

VAB:	WPS_29750(kal)

GEP:	Q9293_15640

FNU:

FN1869

FNC:	HMPREF0946_01617

FNT:	HMPREF0405_01361

FUS:	HMPREF0409_01397

FNE:	FSDG_01972

FHW:	RN87_00410

FPD:	CTM68_06720

FVA:	FV113G1_13750

FUL:	C4N20_15470

FGO:	C4N16_05130

FNF:	BSQ88_03845

FPEI:

C4N17_12355

FCI:	I6I83_03000

FHO:	H9Q81_09960

FPOL:

ERS445057_00490

CSOM:

MKD34_03775

PGI:

PG_1067

PGN:

PGN_1163

PGT:	PGTDC60_1141

PAH:	Poras_0573

PCRE:

NCTC12858_01513

PCAG:

NCTC12856_01002

PEND:

LA319_06735

PSOE:

CE91St14_15610(kal)

PET:	PEIBARAKI_4152

OSP:	Odosp_3170

BUY:	D8S85_10210

BVIR:

I6J59_05620

BFH:	F1611_19370

BACC:

BRDCF_p1075

MBAS:

ALGA_2254

TLE:

Tlet_0225

PHY:	AJ81_05560

TME:

Tmel_0189

TAF:

THA_421

THP:	BG95_02080

THER:

Y592_02085

TFE:	JYK00_06050

FNO:

Fnod_0210

FPE:	Ferpe_0538

FIA:	NA23_03005

FRR:	IB67_05780

OCY:	OSSY52_05690(kal)

PMO:

Pmob_1077

MPZ:	Marpi_0475

MARN:

LN42_02750

MAEO:

JRV97_01895

OCS:	OF820_10890

KOL:

Kole_0966

KPF:	IX53_04755

MPG:	Theba_2114

MINF:

MESINF_1633(kal)

ASAC:

ATHSA_1429

NMR:

Nmar_0564

LOB:	NEF87_002598

PSYT:

DSAG12_00569

» show all

Reference

1 [PMID:4420467]

Authors

Jeng I, Barker HA.

Title

Purification and properties of l-3-aminobutyryl coenzyme A deaminase from a lysine-fermenting Clostridium.

Journal

J Biol Chem 249:6578-84 (1974)

Reference

2 [PMID:7410315]

Authors

Barker HA, Kahn JM, Chew S.

Title

Enzymes involved in 3,5-diaminohexanoate degradation by Brevibacterium sp.

Journal

J Bacteriol 143:1165-70 (1980)
DOI:10.1128/JB.143.3.1165-1170.1980

Other DBs

ExplorEnz - The Enzyme Database:

4.3.1.14

IUBMB Enzyme Nomenclature:

4.3.1.14

ExPASy - ENZYME nomenclature database:

4.3.1.14

BRENDA, the Enzyme Database:

4.3.1.14

CAS:	55467-41-9

DBGET integrated database retrieval system