Entry Name (R)-1-hydroxy-2-aminoethylphosphonate ammonia-lyase;
Class Lyases;BRITE hierarchy
Sysname (1R)-(2-amino-1-hydroxyethyl)phosphonate ammonia-lyase
Reaction(IUBMB) (1R)-(2-amino-1-hydroxyethyl)phosphonate = phosphonoacetaldehyde + NH3 (overall reaction) [RN:
R13195 ];
(1a) (1R)-(2-amino-1-hydroxyethyl)phosphonate = (E)-2-aminoethenylphosphonate + H2O [RN:
R13193 ];
(1b) (E)-2-aminoethenylphosphonate + H2O = phosphonoacetaldehyde + NH3 [RN:
R13194 ]
Reaction(KEGG) Substrate (1R)-(2-amino-1-hydroxyethyl)phosphonate [CPD:
C22696 ];
(E)-2-aminoethenylphosphonate [CPD:
C22697 ];
H2O [CPD:
C00001 ]
Product Comment A pyridoxal 5'-phosphate enzyme. This bacterial enzyme, characterized from the marine bacterium Vibrio splendidus, expands the substrate scope of a widespread pathway for the degradation of 2-aminoethylphosphonate. The enzyme is highly specific and does not act on the S enantiomer of 1-hydroxy-2-aminoethylphosphonate or other structurally related compounds.
History EC 4.3.1.33 created 2023
Orthology K26913 (R)-1-hydroxy-2-aminoethylphosphonate ammonia-lyase
Genes AEL : NCTC12917_03270(dgdA)
SDYN : Mal52_56570(patA_4)
» show all Taxonomy Reference Authors Zangelmi E, Stankovic T, Malatesta M, Acquotti D, Pallitsch K, Peracchi A.
Title Discovery of a New, Recurrent Enzyme in Bacterial Phosphonate Degradation: (R)-1-Hydroxy-2-aminoethylphosphonate Ammonia-lyase.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 4.3.1.33
ExPASy - ENZYME nomenclature database: 4.3.1.33
