Entry |
|
Name |
formimidoyltetrahydrofolate cyclodeaminase;
formiminotetrahydrofolate cyclodeaminase;
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)
|
Class |
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
|
Sysname |
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)
|
Reaction(IUBMB) |
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3 [RN: R02302]
|
Reaction(KEGG) |
|
Substrate |
5-formimidoyltetrahydrofolate [CPD: C00664]
|
Product |
5,10-methenyltetrahydrofolate [CPD: C00445];
NH3 [CPD: C00014]
|
Comment |
In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.
|
History |
EC 4.3.1.4 created 1961, modified 2000
|
Pathway |
|
Orthology |
K01746 | formiminotetrahydrofolate cyclodeaminase |
K13990 | glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase |
|
Genes |
RFQ: | 117013051(FTCD) 117013316 |
SCAN: | 103814589(FTCD) 103824679 |
CVF: | 104292085(FTCD) 104293790 |
CAUA: | 113039469 113039563 |
MANU: | 129452655 129454253 |
SASA: | 100306782(ftcd) 106575213 |
STRU: | 115179273 115195985 |
OGO: | 124008890 124011026(ftcd) |
OKI: | 109890646 109906682(ftcd) |
SALP: | 111953479 111970962 112074004 |
SNH: | 120033602(ftcd) 120051253 |
PPOI: | 119096717 119096863 |
LPOL: | 106473819 106474591 |
RPHI: | 132733559 132741957 |
DFA: | DFA_02269 DFA_10621(ftcd) |
DAT: | HRM2_43160(ftcD1) HRM2_44060(ftcD2) |
PMZ: | HMPREF0659_A6723(ftcD) |
PDN: | HMPREF9137_1323(ftcD) |
» show all
|
Reference |
1 |
Authors |
Rabinowitz, J.C. and Pricer, W.E. |
Title |
Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid. |
Journal |
J Am Chem Soc 78:5702-5704 (1956) |
Other DBs |
ExplorEnz - The Enzyme Database: | 4.3.1.4 |
ExPASy - ENZYME nomenclature database: | 4.3.1.4 |
BRENDA, the Enzyme Database: | 4.3.1.4 |
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