KEGG   ENZYME: 4.3.2.11
Entry
EC 4.3.2.11                 Enzyme                                 
Name
(3R)-3-[(carboxylmethyl)amino]fatty acid synthase;
scoD (gene name);
mmaD (gene name)
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
Sysname
(3R)-3-[(carboxylmethyl)amino]fatty acid glycine-lyase ((2E)-unsaturated fatty acyl-[acyl-carrier protein]-forming)
Reaction(IUBMB)
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein] = a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O [RN:R13038]
Reaction(KEGG)
R13038
Substrate
(3R)-3-[(carboxylmethyl)amino]fatty acid [CPD:C22516];
[acyl-carrier protein] [CPD:C00229]
Product
(2E)-unsaturated fatty acyl-[acyl-carrier protein] [CPD:C00693];
glycine [CPD:C00037];
H2O [CPD:C00001]
Comment
The enzyme, found in some actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides. It catalyses the formation of (3R)-3-[(carboxylmethyl)amino]fatty acid by the addition of glycine and the release of the product from the acyl-carrier protein.
History
EC 4.3.2.11 created 2022
Orthology
K26055  (3R)-3-[(carboxylmethyl)amino]fatty acid synthase
Genes
MMAI: sS8_4510
HNA: Hneap_0956
CHRO: CXB49_14785
BCAI: K788_0006365
SUR: STAUR_1687
MBD: MEBOL_003554
CFUS: CYFUS_003180
HOH: Hoch_6016
MTU: Rv0098(fcoT)
MTV: RVBD_0098
MTC: MT0107
MRA: MRA_0102
MTF: TBFG_10099
MTB: TBMG_00099
MTK: TBSG_00099
MTZ: TBXG_000099
MTG: MRGA327_00630
MTI: MRGA423_00630
MTE: CCDC5079_0086
MTUR: CFBS_0104
MTL: CCDC5180_0087
MTO: MTCTRI2_0101
MTD: UDA_0098
MTN: ERDMAN_0115
MTJ: J112_00545
MTUB: MT7199_0100(fcoT)
MTUC: J113_00665
MTUE: J114_00550
MTX: M943_00550
MTUH: I917_00705
MTUL: TBHG_00099
MTUT: HKBT1_0104
MTUU: HKBT2_0104
MTQ: HKBS1_0104
MBO: BQ2027_MB0101(fcot)
MBB: BCG_0131
MBT: JTY_0102
MBM: BCGMEX_0102
MBK: K60_001100
MBX: BCGT_3893
MAF: MAF_00990
MMIC: RN08_0115
MCE: MCAN_01011
MCQ: BN44_10121
MCV: BN43_10116
MCX: BN42_10136
MCZ: BN45_10114
MORY: MO_000107(fcoT)
MLE: ML1993
MLB: MLBr01993
MUL: MUL_4855
MMI: MMAR_0259
MMAE: MMARE11_02420
MLI: MULP_00231
MPSE: MPSD_53400
MSHO: MSHO_13060
MYV: G155_20085
MHAD: B586_11340
MSHG: MSG_00072 MSG_03153
MLW: MJO58_18020 MJO58_18055
MPAG: C0J29_01605
MGOR: H0P51_07730
MBAI: MB901379_00193
MSPG: F6B93_01075
MLM: MLPF_3234(fcoT)
MKY: IWGMT90018_16030
MWU: PT015_11530
MFT: XA26_41010
MFX: MFAL_24240
MIJ: MINS_08850
MALV: MALV_54140
MHEV: MHEL_38340 MHEL_38410
MSAR: MSAR_36850 MSAR_36920
MAUB: MAUB_23300 MAUB_23360
MPHU: MPHO_47190
MMUC: C1S78_023660
MBOK: MBOE_32790
MFG: K6L26_11645
MBRM: L2Z93_003585
MSEN: K3U95_09860
MAB: MAB_0660
MMV: MYCMA_0347
MABB: MASS_0631
MABL: MMASJCM_0650
MCHE: BB28_03150
MIZ: BAB75_03940
MSTE: MSTE_00615
MSAO: MYCSP_02840
MSAL: DSM43276_00571
MMIN: MMIN_13060
MHER: K3U94_21320
MVM: MJO54_21215
CPRE: Csp1_27290
CHEI: CHEID_00370
CAUI: CAURIS_08505
CFEU: CFELI_06605
CHAN: CHAN_10745
NBR: O3I_034370
NTP: CRH09_21100
NOZ: DMB37_13100
NAH: F5544_19265
NIE: KV110_32410 KV110_33065
NYU: D7D52_08835
GAM: GII34_17740
GPD: GII33_17150
SMA: SAVERM_606
SGB: WQO_03770
SBH: SBI_00520
SGM: GCM10017557_04930
SNW: BBN63_00230
SGE: DWG14_02622
SBY: H7H31_00880 H7H31_26460
STSU: B7R87_01585
SBRO: GQF42_33755
SHAR: HUT13_09605
SMAO: CAG99_19770
SCAE: IHE65_04255
SKG: KJK29_00720
STTN: BSL84_14070
STRZ: OYE22_00975 OYE22_25745
AMYC: CU254_21775
KAL: KALB_7699
CCAZ: COUCH_33500
LEP: Lepto7376_4249
NSH: GXM_09948
NED: HUN01_03910
CSG: Cylst_3962
HBQ: QI031_30710
RML: FF011L_31820
 » show all
Reference
1  [PMID:28634299]
  Authors
Harris NC, Sato M, Herman NA, Twigg F, Cai W, Liu J, Zhu X, Downey J, Khalaf R, Martin J, Koshino H, Zhang W.
  Title
Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria.
  Journal
Proc Natl Acad Sci U S A 114:7025-7030 (2017)
DOI:10.1073/pnas.1705016114
  Sequence
[mtu:Rv0098]
Reference
2  [PMID:29906336]
  Authors
Harris NC, Born DA, Cai W, Huang Y, Martin J, Khalaf R, Drennan CL, Zhang W.
  Title
Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.
  Journal
Angew Chem Int Ed Engl 57:9707-9710 (2018)
DOI:10.1002/anie.201804307
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.11
IUBMB Enzyme Nomenclature: 4.3.2.11
ExPASy - ENZYME nomenclature database: 4.3.2.11
BRENDA, the Enzyme Database: 4.3.2.11

  All links  
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (138)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (137)   
Protein sequence (467)   
   UniProt (462)   
   SWISS-PROT (5)   
Protein domain (2)   
   InterPro (2)   
All databases (613)   

Download RDF
DBGET integrated database retrieval system