Entry
Name
purine imidazole-ring cyclase;
DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing);
DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing;
DNA-adenine-forming)
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
BRITE hierarchy
Sysname
DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)
Reaction(IUBMB)
DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O [RN:
R02960 ]
Reaction(KEGG)
Substrate
DNA 4,6-diamino-5-formamidopyrimidine [CPD:
C04381 ]
Product
Comment
Also acts on 2,6-diamino-5-formamido-3,4-dihydro-4-oxopyrimidine residues. Brings about the reclosure of the imidazole rings of purine residues damaged by gamma-rays.
History
EC 4.3.2.4 created 1989
Reference
Authors
Chetsanga CJ, Grigorian C.
Title
In situ enzymatic reclosure of opened imidazole rings of purines in DNA damaged by gamma-irradiation.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.4
ExPASy - ENZYME nomenclature database: 4.3.2.4
BRENDA, the Enzyme Database: 4.3.2.4