KEGG ENZYME: 4.3.3.5

ENZYME: 4.3.3.5

Entry

EC 4.3.3.5                  Enzyme

Name

4'-demethylrebeccamycin synthase;
arcyriaflavin A N-glycosyltransferase;
RebG

Class

Lyases;
Carbon-nitrogen lyases;
Amine-lyases

Sysname

4'-demethylrebeccamycin D-glucose-lyase

Reaction(IUBMB)

4'-O-demethylrebeccamycin + H2O = dichloro-arcyriaflavin A + beta-D-glucose [RN:R09568]

Reaction(KEGG)

R09568

Substrate

4'-O-demethylrebeccamycin [CPD:C19700];
H2O [CPD:C00001]

Product

dichloroarcyriaflavin A [CPD:C19699];
beta-D-glucose [CPD:C00221]

Comment

This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a glycosylase, and acts in the reverse direction to that shown. It has a wide substrate range, and was shown to glycosylate several substrates, including the staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole [1,2].

History

EC 4.3.3.5 created 2010

Pathway

ec00404

Staurosporine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19888

4'-demethylrebeccamycin synthase