| Entry |
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| Name |
holocytochrome-c synthase;
cytochrome c heme-lyase;
holocytochrome c synthetase;
holocytochrome-c apocytochrome-c-lyase
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| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
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| Sysname |
holocytochrome-c apocytochrome-c-lyase (heme-forming)
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| Reaction(IUBMB) |
holocytochrome c = apocytochrome c + heme [RN: R02480]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
In the reverse direction, the enzyme catalyses the attachment of heme to two cysteine residues in the protein, forming thioether links.
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| History |
EC 4.4.1.17 created 1990
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| Pathway |
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| Orthology |
| K01764 | cytochrome c heme-lyase |
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| Genes |
| CANG: | 105505802 105518060 |
| MORG: | 121443095 121445585 |
| CPOC: | 100714444 100724972 100732458 |
| NCAR: | 124971771 124983133 124987069 124988981 124989086 |
| MMMA: | 107144223 107150256 |
| CCAD: | 122435357 122438375 |
| AVIT: | 104267591 104278135 |
| XLA: | 380272(hccs.L) 447038(hccs.S) |
| DRE: | 101882578(hccsa.2) 436771(hccsa.1) 58016(hccsb) |
| SRX: | 107710606 107712780 107739016 |
| SANH: | 107657763 107677261 107700523 |
| SGH: | 107560652 107578870 107594665 |
| CCAR: | 109049114 109055621 109066001 109088535 |
| CAUA: | 113042560 113045499 113080166 113093825 |
| CGIB: | 127945999 127951655 128012820 |
| PTET: | 122324815 122329395 |
| LROH: | 127156162 127174148 |
| PPRM: | 120468569 120488436 |
| MAMB: | 125251277 125258184 |
| CIDE: | 127496075 127503831 127505780 |
| MASI: | 127431824 127434476 127441065 127442412 |
| TROS: | 130547089 130554336 |
| MANU: | 129425542 129442394 |
| PHYP: | 113534127 113539254 |
| SMEO: | 124383771 124394653 |
| TFD: | 113642416 113644185 125145944 |
| AMEX: | 103025288 103031157 |
| CMAO: | 118804695 118818445 |
| CHAR: | 105889394 105910811 |
| TNG: | GSTEN00002264G001 GSTEN00026456G001 |
| CGOB: | 115005938 115005939 |
| SASA: | 106578494(CCHL) 106599140 |
| STRU: | 115153158 115169891 |
| SALP: | 111973129 111979647 |
| CCLU: | 121550108 121581483 |
| AANG: | 118224600 118230017 |
| PSPA: | 121326351 121330471 |
| ARUT: | 117403932 117416744 |
| DSI: | Dsimw501_GD18482(Dsim_GD18482) |
| AMER: | 121589085 121601736 |
| AALB: | 109397080 115258008 |
| CCAL: | 108632806 108632807 |
| APLN: | 108744530 108744532 108744534 |
| SLIU: | 111349231 111364066 |
| SGRE: | 126281391 126325924 126353502 |
| CQD: | 128690917 128690925 128705575 |
| PPOI: | 119098621 119099254 |
| CEL: | CELE_T06D8.6(cchl-1) |
| CBR: | CBG_02944(Cbr-cchl-1) |
| BMY: | BM_BM5614(Bma-cchl-1) |
| TSP: | Tsp_01197 Tsp_01200 Tsp_01207 Tsp_01210 |
| SMO: | SELMODRAFT_4287 SELMODRAFT_4288 |
| CRE: | CHLRE_12g525700v5 CHLRE_12g526030v5 CHLRE_12g526326v5 CHLRE_16g690050v5 |
| VCN: | VOLCADRAFT_105944 VOLCADRAFT_75232 |
| CVR: | CHLNCDRAFT_35847 CHLNCDRAFT_56330 |
| APRO: | F751_1016 F751_2256 |
| OLU: | OSTLU_10461 OSTLU_13359 |
| OTA: | OT_ostta17g01000 OT_ostta17g01450 |
| BPG: | Bathy06g00700 Bathy06g03560 |
| MIS: | MICPUN_76259 MICPUN_76264 |
| MPP: | MICPUCDRAFT_5948(JGI:MicpuC2_5948) MICPUCDRAFT_6472(JGI:MicpuC2_6472) |
| SCE: | YAL039C(CYC3) YKL087C(CYT2) |
| SEUB: | DI49_0022 DI49_3288 |
| SPAO: | SPAR_A00250 SPAR_K01250 |
| AGO: | AGOS_ADR154W AGOS_ADR382W |
| KLA: | KLLA0_C13123g KLLA0_F25894g |
| KMX: | KLMA_60164(CYT2) KLMA_80238(CYC3) |
| LTH: | KLTH0C01100g KLTH0D01320g |
| VPO: | Kpol_1058p50 Kpol_461p20 |
| ZRO: | ZYRO0D04818g ZYRO0E00814g |
| CGR: | CAGL0L05280g CAGL0M12012g |
| NCS: | NCAS_0A07580(NCAS0A07580) NCAS_0H03340(NCAS0H03340) |
| NDI: | NDAI_0C00320(NDAI0C00320) NDAI_0H01140(NDAI0H01140) |
| TPF: | TPHA_0N00340(TPHA0N00340) TPHA_0N01700(TPHA0N01700) |
| TBL: | TBLA_0C00880(TBLA0C00880) TBLA_0F01590(TBLA0F01590) |
| TGB: | HG536_0F04320 HG536_0G00410 |
| TDL: | TDEL_0B07380(TDEL0B07380) TDEL_0H04130(TDEL0H04130) |
| KAF: | KAFR_0K00500(KAFR0K00500) |
| KNG: | KNAG_0D05010(KNAG0D05010) KNAG_0H00300(KNAG0H00300) |
| ZMK: | HG535_0E02440 HG535_0H00430 |
| PPA: | PAS_chr2-2_0290 PAS_chr2-2_0293 |
| DHA: | DEHA2E12056g DEHA2G18128g |
| PIC: | PICST_33494(CYC3) PICST_37815(CYT2) |
| SPAA: | SPAPADRAFT_139387 SPAPADRAFT_58655 |
| LEL: | PVL30_003934(CYT2) PVL30_004548(CYC3) |
| CAL: | CAALFM_C402130WA(CYT2) CAALFM_C501130WA(CYC3) |
| CTP: | CTRG_00019 CTRG_05366 |
| COT: | CORT_0E00660 CORT_0E06040 |
| CDU: | CD36_42020 CD36_51200(CYC3) |
| CTEN: | CANTEDRAFT_114157 CANTEDRAFT_114733 |
| YLI: | YALI0C12918g YALI0E06215g |
| CLU: | CLUG_00858 CLUG_05021 |
| CLUS: | A9F13_03g02134 A9F13_10g01375 |
| CAUR: | CJI96_0001143 CJI96_0001247 |
| SLB: | AWJ20_1725(CYT2) AWJ20_3176(CYC3) |
| PKZ: | C5L36_0C05560 C5L36_0D04740 |
| BNN: | FOA43_000910 FOA43_001105(CYC3) |
| BBRX: | BRETT_003583(CYC3) BRETT_004945 |
| OPA: | HPODL_00370 HPODL_01061 |
| SLUD: | SCDLUD_003096 SCDLUD_003363 |
| NCR: | NCU05601(cyt-2) NCU08138 |
| NTE: | NEUTE1DRAFT131836(NEUTE1DRAFT_131836) NEUTE1DRAFT86485(NEUTE1DRAFT_86485) |
| SMP: | SMAC_03315 SMAC_03609 |
| PAN: | PODANSg0992 PODANSg1077 |
| PBEL: | QC761_0064510(CYC3) QC761_502600 |
| PPSD: | QC762_409690(CYC3) QC762_502600 |
| PPSP: | QC763_409690(CYC3) QC763_502600 |
| PPSA: | QC764_409690(CYC3) QC764_502600 |
| TTT: | THITE_2118090 THITE_74570 |
| MTM: | MYCTH_2305747 MYCTH_68944 |
| PPEI: | PpBr36_05092 PpBr36_10149 |
| PGRI: | PgNI_07463 PgNI_11950 |
| TMN: | UCRPA7_6766 UCRPA7_8817 |
| SSCK: | SPSK_03527 SPSK_07694 |
| FGR: | FGSG_08386 FGSG_10422 |
| FPU: | FPSE_07435 FPSE_09002 |
| FPOA: | FPOAC1_003449 FPOAC1_004486 |
| FVN: | FVRRES_03884 FVRRES_04987 |
| FVR: | FVEG_02310 FVEG_03161 |
| FOX: | FOXG_03436 FOXG_04974 |
| NHE: | NECHADRAFT_49910 NECHADRAFT_67121 |
| FFC: | NCS54_00376900 NCS54_01238800 |
| FKR: | NCS57_00382300 NCS57_01228500 |
| FMU: | J7337_006062 J7337_008648 |
| TRE: | TRIREDRAFT_77758 TRIREDRAFT_79769 |
| TRR: | M419DRAFT_113588 M419DRAFT_24621 |
| PCHM: | VFPPC_03328 VFPPC_13064 |
| AMUS: | LMH87_000324 LMH87_011423 |
| PLJ: | VFPFJ_02645 VFPFJ_03891 |
| PTKZ: | JDV02_002492(CYT2) JDV02_008581(CYC3) |
| VAL: | VDBG_02887 VDBG_09579 |
| VDA: | VDAG_03797 VDAG_04812 |
| CFJ: | CFIO01_01187 CFIO01_02578 |
| CLUP: | CLUP02_16112 CLUP02_16814 |
| CHIG: | CH63R_06590 CH63R_12434 |
| ELA: | UCREL1_1001 UCREL1_11669 |
| PFY: | PFICI_08662 PFICI_09985 |
| SSL: | SS1G_03957 SS1G_04774 |
| BFU: | BCIN_01g03060(Bccyc3) BCIN_04g01900(Bccyt2) |
| PSCO: | LY89DRAFT_653739 LY89DRAFT_682461 |
| GLZ: | GLAREA_00023 GLAREA_09017 |
| ANI: | ANIA_04415 ANIA_10879 |
| AFM: | AFUA_4G04600 AFUA_4G07120 |
| ACT: | ACLA_046430 ACLA_053760 |
| NFI: | NFIA_028760 NFIA_109100 |
| AOR: | AO090023000863 AO090206000030 |
| ANG: | An04g01535 An14g00240 |
| AFV: | AFLA_007215 AFLA_012997 |
| ALUC: | AKAW2_40712S(CYC3) AKAW2_51184A(CYT2) |
| ACHE: | ACHE_20613A(CYT2) ACHE_31044S(CYC3) |
| APUU: | APUU_70608A(CYT2) APUU_80654S(CYC3) |
| PCS: | N7525_003580 N7525_004519 |
| PDP: | PDIP_12900 PDIP_14980 |
| POU: | POX_b02171 POX_f07763 |
| TMF: | EYB26_001175 EYB26_004645 |
| TRG: | TRUGW13939_02007 TRUGW13939_03405 |
| CIM: | CIMG_04155 CIMG_08537 |
| CPW: | CPC735_002640 CPC735_061960 |
| URE: | UREG_02601 UREG_05589 |
| PBL: | PAAG_01468 PAAG_07590 |
| PBN: | PADG_00312 PADG_08289 |
| AJE: | HCAG_05597 HCAG_07691 |
| BGH: | BDBG_02641 BDBG_09133 |
| PNO: | SNOG_04831 SNOG_08294 |
| BZE: | COCCADRAFT_110134 COCCADRAFT_86313 |
| BSC: | COCSADRAFT_174262 COCSADRAFT_33308 |
| BOR: | COCMIDRAFT_35311 COCMIDRAFT_96815 |
| AALT: | CC77DRAFT_1017667 CC77DRAFT_211153 |
| ARAB: | EKO05_0004839 EKO05_0007221 |
| ZTR: | MYCGRDRAFT_111377 MYCGRDRAFT_35508 |
| PFJ: | MYCFIDRAFT_168848 MYCFIDRAFT_210968 |
| FFU: | CLAFUR5_10244 CLAFUR5_13532 |
| CBET: | CB0940_05273 CB0940_06554 |
| BCOM: | BAUCODRAFT_68383 BAUCODRAFT_77263 |
| NPA: | UCRNP2_7007 UCRNP2_7751 |
| TML: | GSTUM_00005253001 GSTUM_00008492001 |
| SPO: | SPAC24C9.02c SPBC26H8.12 |
| SOM: | SOMG_00267(cyt2) SOMG_00500(cyc3) |
| CNG: | CNAG_00022 CNAG_05875 |
| CGI: | CGB_B0150C CGB_F5320C |
| TMS: | TREMEDRAFT_28522 TREMEDRAFT_74912 |
| CCAC: | CcaHIS019_0407150(CYT2) CcaHIS019_0502990(CYC3) |
| TVS: | TRAVEDRAFT_28071 TRAVEDRAFT_64986 |
| DSQ: | DICSQDRAFT_100946 DICSQDRAFT_77440 |
| SHS: | STEHIDRAFT_166440 STEHIDRAFT_79252 |
| HIR: | HETIRDRAFT_420076 HETIRDRAFT_43172 |
| FME: | FOMMEDRAFT_73292 FOMMEDRAFT_79763 |
| GTR: | GLOTRDRAFT_115655 GLOTRDRAFT_23433 |
| CCI: | CC1G_00860 CC1G_05134 |
| ABP: | AGABI1DRAFT111393(AGABI1DRAFT_111393) AGABI1DRAFT111983(AGABI1DRAFT_111983) |
| ABV: | AGABI2DRAFT193225(AGABI2DRAFT_193225) AGABI2DRAFT216724(AGABI2DRAFT_216724) |
| PCUB: | JR316_0003649 JR316_0008009 |
| MRR: | Moror_14849 Moror_17278 |
| MORE: | E1B28_002638 E1B28_007672 |
| CPUT: | CONPUDRAFT_135151 CONPUDRAFT_59341 |
| SLA: | SERLADRAFT_351042 SERLADRAFT_472834 |
| WSE: | WALSEDRAFT_20182 WALSEDRAFT_60258 |
| UMA: | UMAG_04702 UMAG_11653 |
| PFP: | PFL1_01119 PFL1_04421 |
| SGRA: | EX895_000264 EX895_004240 |
| MSYM: | MSY001_0021 MSY001_2210 |
| PGR: | PGTG_00085 PGTG_01941 |
| PTRC: | PtA15_16A279 PtA15_1A105 |
| PSTR: | Pst134EA_001062 Pst134EA_017258 Pst134EA_022968 Pst134EA_022975 |
| MLR: | MELLADRAFT_28382 MELLADRAFT_48758 |
| MBR: | MONBRDRAFT_27974 MONBRDRAFT_38782 |
| SRE: | PTSG_04025 PTSG_07135 |
| PFA: | PF3D7_1203600 PF3D7_1224600 |
| PFH: | PFHG_02931 PFHG_05120 |
| PGAB: | PGSY75_1203600 PGSY75_1224600 |
| PYO: | PY17X_0605100 PY17X_1442000 |
| PCB: | PCHAS_0604400 PCHAS_1441500 |
| PBE: | PBANKA_0602600 PBANKA_1439500 |
| PVV: | PVVCY_0600280 PVVCY_1404160 |
| PKN: | PKNH_1303400 PKNH_1443900 |
| PVX: | PVX_084225 PVX_123860 |
| PCY: | PCYB_131240 PCYB_145030 |
| PMAL: | PMUG01_13013900 PMUG01_14058900 |
| PREL: | PRELSG_1302700 PRELSG_1440200 |
| TOT: | TOT_010000834 TOT_020000776 |
| BEQ: | BEWA_027130 BEWA_040630 |
| BBO: | BBOV_III011500 BBOV_IV008890 |
| BMIC: | BMR1_03g00830 BmR1_04g08205 |
| BBIG: | BBBOND_0106360 BBBOND_0211280 |
| TGO: | TGME49_293390 TGME49_314042 |
| SMIN: | v1.2.025477.t1(symbB.v1.2.025477.t1) v1.2.033285.t1(symbB.v1.2.033285.t1) |
| PTI: | PHATRDRAFT_40930 PHATRDRAFT_6437 |
| FCY: | FRACYDRAFT_163984 FRACYDRAFT_202199 FRACYDRAFT_261492 |
| PIF: | PITG_00110 PITG_00442 |
| PSOJ: | PHYSODRAFT_334052 PHYSODRAFT_506708 |
| SPAR: | SPRG_03495 SPRG_05268 |
| EHX: | EMIHUDRAFT_435905 EMIHUDRAFT_439014 EMIHUDRAFT_440203 EMIHUDRAFT_464044 EMIHUDRAFT_465131 |
| GTT: | GUITHDRAFT_65435 GUITHDRAFT_73289 |
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| Reference |
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| Authors |
Dumont ME, Ernst JF, Hampsey DM, Sherman F |
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| Title |
Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.4.1.17 |
| ExPASy - ENZYME nomenclature database: | 4.4.1.17 |
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