KEGG   ENZYME: 4.4.1.20
Entry
EC 4.4.1.20                 Enzyme                                 
Name
leukotriene-C4 synthase;
leukotriene C4 synthetase;
LTC4 synthase;
LTC4 synthetase;
leukotriene A4:glutathione S-leukotrienyltransferase;
(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening);
(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
Reaction(IUBMB)
leukotriene C4 = leukotriene A4 + glutathione [RN:R03059]
Reaction(KEGG)
R03059
Substrate
leukotriene C4 [CPD:C02166]
Product
leukotriene A4 [CPD:C00909];
glutathione [CPD:C00051]
Comment
The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase.
History
EC 4.4.1.20 created 1989 as EC 2.5.1.37, transferred 2004 to EC 4.4.1.20
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00807  leukotriene-C4 synthase
Genes
HSA4056(LTC4S)
PTR739986(LTC4S)
PPS100983593(LTC4S)
GGO101148178(LTC4S)
PON100456952(LTC4S)
HMH116471951(LTC4S)
MCC705233(LTC4S)
MCF102141868(LTC4S)
MTHB126956934
MNI105483999(LTC4S)
CSAB103245108(LTC4S)
CATY105590406(LTC4S)
PANU101019292(LTC4S)
TGE112626468(LTC4S)
MLEU105537281(LTC4S)
RRO104676203(LTC4S)
RBB108523369(LTC4S)
TFN117064350(LTC4S)
PTEH111527422(LTC4S)
CJC100385291(LTC4S)
CIMI108295216(LTC4S)
MMUR105885202(LTC4S)
PCOQ105823268(LTC4S)
OGA100955913(LTC4S)
MMU17001(Ltc4s)
MCAL110305673(Ltc4s)
RNO114097(Ltc4s)
MCOC116077408(Ltc4s)
ANU117711490(Ltc4s)
CGE113836822
MAUA101829074(Ltc4s)
PROB127219348(Ltc4s)
PLEU114681491(Ltc4s)
MORG121457066(Ltc4s)
MFOT126511469
AAMP119812452(Ltc4s)
NGI103749375(Ltc4s)
HGL101722474(Ltc4s)
CPOC100725689(Ltc4s)
CCAN109686722(Ltc4s)
DORD105996742(Ltc4s)
DSP122115470(Ltc4s)
PLOP125342035(Ltc4s)
NCAR124987187
MMMA107159804(Ltc4s)
OCU100341898
OPI101526783(LTC4S)
GVR103600667(LTC4S)
CFA607316(LTC4S)
CLUD112659688(LTC4S)
VVP112932405(LTC4S)
VLG121495583(LTC4S)
NPO129494898(LTC4S)
AML105238479(LTC4S)
UMR121100662(LTC4S)
UAH113261556(LTC4S)
UAR123790490(LTC4S)
ELK111158923
MPUF101681631(LTC4S)
MNP132027426(LTC4S)
MLK131832653(LTC4S)
NVS122900801(LTC4S)
ORO101378794(LTC4S)
EJU114201192(LTC4S)
ZCA113929399(LTC4S)
MLX118026475(LTC4S)
NSU110580272(LTC4S)
LWW102726515(LTC4S)
FCA101096198(LTC4S)
PYU121010522(LTC4S)
PCOO112861212(LTC4S)
PBG122485987(LTC4S)
LRUF124521007
PTG102964525(LTC4S)
PPAD109278966(LTC4S)
PUC125935360
AJU106970167
HHV120245668(LTC4S)
BTA511749(LTC4S)
BOM102278603(LTC4S)
BBUB102414907(LTC4S)
BBIS104981752(LTC4S)
OAS101119304(LTC4S)
BTAX128051643(LTC4S)
CCAD122440584(LTC4S)
MBEZ129558597(LTC4S)
SSC100520063(LTC4S)
CFR116658955(LTC4S)
CBAI105062007(LTC4S)
CDK116148476(LTC4S)
BACU103011981(LTC4S)
LVE103085740(LTC4S)
OOR101285904(LTC4S)
DLE111169283(LTC4S)
PCAD102993996(LTC4S)
PSIU116751355(LTC4S)
NASI112413132(LTC4S)
ECB100067282(LTC4S)
EPZ103560012(LTC4S)
EAI106843724(LTC4S)
MMYO118658618(LTC4S)
PKL118725943(LTC4S)
EFUS103301664(LTC4S)
HAI109392760(LTC4S)
DRO112296409(LTC4S)
SHON118995094(LTC4S)
AJM119042626(LTC4S)
PDIC114510033(LTC4S)
PHAS123808677(LTC4S)
MMF118615263(LTC4S)
RFQ117016804(LTC4S)
PPAM129064967(LTC4S)
PALE102882511(LTC4S)
PGIG120616621(LTC4S)
PVP105299971(LTC4S)
RAY107512319(LTC4S)
MJV108401191(LTC4S)
TOD119236232(LTC4S)
SARA101547520(LTC4S)
LAV100675058(LTC4S)
TMU101361468
ETF101649870(LTC4S)
DNM101436622(LTC4S)
MDO100032154(LTC4S)
GAS123237460(LTC4S)
SHR116421692(LTC4S)
AFZ127550317
PCW110216768(LTC4S)
OAA114807422(LTC4S)
GGA770619(LTC4S) 770665(LTC4SL)
PCOC116232167 116232169
MGP100543887 100551070
CJO107320125 107320232
TPAI128081524 128081680(LTC4S)
LMUT125700155 125700212
NMEL110405439 110405512
APLA101803851 101804397
ACYG106032815 106032894
CATA118260567 118260569
AFUL116494761 116494904
TGU100218541 100219450
LSR110482719 110482722
SCAN103817291 103817479(LTC4S)
PMOA120498564 120498613(LTC4S)
OTC121332393 121332400
PRUF121361386 121361397
GFR102044383 102044843(LTC4S)
FAB101806252 101806896(LTC4S)
OMA130258719 130258972
PHI102109119 102111820
PMAJ107210533 107210696
CCAE111935555 111935558
CCW104689587 104689589
CBRC103611394 103611396
ETL114065215(LTC4S) 114071247
ZAB102071342 102071700
ACHL103799871(LTC4S) 103802950
SVG106859600 106859604
MMEA130579347 130579365
HRT120759208 120759296
FPG101917253 101919677(LTC4S)
FCH102054340 102055824
CLV102098046 102098404
EGZ104123601 104128439
NNI104014188 104018439
PCRI104023705 104026317(LTC4S)
PLET104618568 104618722(LTC4S)
EHS104506972 104514579(LTC4S)
PCAO104042914 104045217
ACUN113485203(LTC4S) 113485336
TALA104357001 104357925
PADL103915754 103915829
AFOR103904395 103904398
ACHC115334117 115334443
HALD104317407 104317814(LTC4S)
HLE104838888 104838891(LTC4S)
AGEN126050921 126050997
GCL127022057 127022090
CCRI104159890 104167057
CSTI104552782 104557875(LTC4S)
CMAC104475127(LTC4S) 104487068
MUI104536213(LTC4S) 104540151
BREG104637945(LTC4S) 104638529
FGA104071746 104078047
GSTE104254183 104263209(LTC4S)
LDI104345659(LTC4S) 104349351
MNB103770357 103770676
OHA104326890 104326916
NNT104398993 104400966(LTC4S)
SHAB115616165 115616170
DPUB104296163 104310331
PGUU104464903(LTC4S) 104470215
ACAR104518195 104525810
CPEA104386512 104386891
AVIT104274425(LTC4S) 104274752
CVF104293106 104293108(LTC4S)
RTD128915945 128916350
CUCA104059369 104059405
TEO104373965 104378392
BRHI104497725(LTC4S) 104499775
AAM106493451 106493455
AROW112964865(LTC4S) 112964888
NPD112954367 112954407
TGT104571334 104571336
DNE112996911(LTC4S) 112996946
SCAM104142294 104142559
ASN102373647 102374413
AMJ102568686(LTC4S) 102571710
CPOO109310147 109310151
GGN109289903 109289905
PSS102456931 102457340
CMY102936169 102936619
CCAY125640880 125641150(LTC4S)
DCC119860490
CPIC101945657 101946405
TST117882073 117882245
CABI116820058 116820064
MRV120370243 120370346
ACS103277893(ltc4s)
ASAO132768937(LTC4S)
PVT110073491(LTC4S)
SUND121921085(LTC4S)
PBI103060000(LTC4S)
PMUR107296651(LTC4S)
CTIG120306856(LTC4S)
TSR106538648(LTC4S)
PGUT117655377(LTC4S)
APRI131193548(LTC4S)
PTEX113433798(LTC4S)
NSS113424621(LTC4S)
VKO123035857(LTC4S)
PMUA114591332(LTC4S)
PRAF128407946(LTC4S)
ZVI118080408(LTC4S)
HCG128341527(LTC4S)
GJA107110314(LTC4S)
STOW125429074(LTC4S)
EMC129327426(LTC4S)
XLA108712616(ltc4s.1.S) 495166(ltc4s.2.L)
XTR100127769(ltc4s.2) 100379825(ltc4s.1)
NPR108785375
RTEM120932527 120932530
BBUF120986977 121008406(LTC4S)
BGAR122926480(LTC4S) 122928284
MUO115476239(LTC4S)
GSH117351880(LTC4S)
DRE100535432(ltc4s)
SRX107722431 107733419
SANH107660445 107667453
SGH107551000(ltc4s) 107578450
CCAR109081382 109102539
CAUA113113366 113113488
CGIB127971302 127971303 128026932
PTET122357663(ltc4s)
LROH127161697(ltc4s)
OMC131553486(ltc4s)
PPRM120464346(ltc4s)
RKG130102843(ltc4s)
MAMB125258692(ltc4s)
CIDE127494208
MASI127412860 127417542
TROS130563385(ltc4s)
TDW130438147(ltc4s)
MANU129422535(ltc4s)
IPU128628786
IFU128611195(ltc4s)
PHYP113542917(ltc4s)
SMEO124385679(ltc4s)
TFD113647746(ltc4s)
TVC132855528(ltc4s)
AMEX103033591(ltc4s)
CMAO118806482(ltc4s)
EEE113584818(ltc4s)
CHAR105903141(ltc4s)
TRU101079867
TFS130531493(ltc4s)
TNGGSTEN00024281G001
LCO104934865
TBEN117486846 117486852
EFO125894818(ltc4s)
SLUC116062541(ltc4s)
PFLV114563322(ltc4s)
GAT120817689(ltc4s)
PPUG119211050(ltc4s)
AFB129090438(ltc4s)
CLUM117737794(ltc4s)
MSAM119888516(ltc4s)
SCHU122880586(ltc4s)
CUD121516813(ltc4s)
ALAT119007987(ltc4s)
MZE101463928(ltc4s)
ONL100701372(ltc4s)
OAU116329678(ltc4s)
OLA101165938(ltc4s)
OML112137898(ltc4s)
XMA102217258(ltc4s)
XCO114138731(ltc4s)
XHE116714057(ltc4s)
PRET103471803
PFOR103130782
PLAI106936341
PMEI106928913
GAF122837076(ltc4s)
PPRL129354342 129360583
CVG107083789
CTUL119784582(ltc4s)
GMU124860333(ltc4s)
NFU107380837
KMR108251405(ltc4s)
ALIM106530294
NWH119408828(ltc4s)
AOCE111581646
MCEP125008607(ltc4s)
CSEM103391074(ltc4s)
POV109641734
SSEN122760853(ltc4s)
HHIP117769729(ltc4s)
HSP118111808
LCF108873747(ltc4s)
SDU111235924
SLAL111672941
XGL120785156(ltc4s)
HCQ109516552
SSCV125987753
BPEC110165507
MALB109956757
BSPL114864444(ltc4s)
SJO128363233(ltc4s)
SASA106611597(ltc4s)
STRU115205135(ltc4s)
OTW112256314(ltc4s)
OMY110505101(ltc4s)
OGO124010924(ltc4s)
ONE115129530(ltc4s)
OKI109905259(ltc4s)
OKE118363572(ltc4s)
SALP111967563(ltc4s)
SNH120061991(ltc4s)
CCLU121535800 121537030 123490828
ELS105028348(ltc4s)
SFM108925352(ltc4s)
PKI111859874(ltc4s)
AANG118223010(ltc4s)
LOC102698624(ltc4s)
PSPA121296961 121323789
ARUT117413502 117431402
PSEX120542415(ltc4s)
LCM102356667(LTC4S) 102366002
CMK103188230(ltc4s)
RTP109915474
CPLA122556460(ltc4s)
HOC132823287(ltc4s)
LERI129701576(ltc4s)
PMRN116942975
LRJ133343015
 » show all
Reference
1  [PMID:6324687]
  Authors
Bach MK, Brashler JR, Morton DR Jr.
  Title
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.
  Journal
Arch Biochem Biophys 230:455-65 (1984)
DOI:10.1016/0003-9861(84)90426-0
Reference
2  [PMID:2846379]
  Authors
Shimizu T.
  Title
Enzymes functional in the syntheses of leukotrienes and related compounds.
  Journal
Int J Biochem 20:661-6 (1988)
DOI:10.1016/0020-711x(88)90160-7
Reference
3  [PMID:12432940]
  Authors
Lam BK, Austen KF.
  Title
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes.
  Journal
Prostaglandins Other Lipid Mediat 68-69:511-20 (2002)
DOI:10.1016/S0090-6980(02)00052-7
Reference
4  [PMID:12023288]
  Authors
Christmas P, Weber BM, McKee M, Brown D, Soberman RJ.
  Title
Membrane localization and topology of leukotriene C4 synthase.
  Journal
J Biol Chem 277:28902-8 (2002)
DOI:10.1074/jbc.M203074200
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.20
IUBMB Enzyme Nomenclature: 4.4.1.20
ExPASy - ENZYME nomenclature database: 4.4.1.20
BRENDA, the Enzyme Database: 4.4.1.20
CAS: 90698-32-1

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