Entry |
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Name |
leukotriene-C4 synthase;
leukotriene C4 synthetase;
LTC4 synthase;
LTC4 synthetase;
leukotriene A4:glutathione S-leukotrienyltransferase;
(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening);
(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
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Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
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Sysname |
leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
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Reaction(IUBMB) |
leukotriene C4 = leukotriene A4 + glutathione [RN: R03059]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase.
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History |
EC 4.4.1.20 created 1989 as EC 2.5.1.37, transferred 2004 to EC 4.4.1.20
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Pathway |
ec00590 | Arachidonic acid metabolism |
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Orthology |
K00807 | leukotriene-C4 synthase |
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Genes |
GGA: | 770619(LTC4S) 770665(LTC4SL) |
PCOC: | 116232167 116232169 |
TPAI: | 128081524 128081680(LTC4S) |
LMUT: | 125700155 125700212 |
NMEL: | 110405439 110405512 |
APLA: | 101803851 101804397 |
ACYG: | 106032815 106032894 |
CATA: | 118260567 118260569 |
AFUL: | 116494761 116494904 |
SCAN: | 103817291 103817479(LTC4S) |
PMOA: | 120498564 120498613(LTC4S) |
PRUF: | 121361386 121361397 |
GFR: | 102044383 102044843(LTC4S) |
FAB: | 101806252 101806896(LTC4S) |
PMAJ: | 107210533 107210696 |
CCAE: | 111935555 111935558 |
CBRC: | 103611394 103611396 |
ETL: | 114065215(LTC4S) 114071247 |
ACHL: | 103799871(LTC4S) 103802950 |
MMEA: | 130579347 130579365 |
FPG: | 101917253 101919677(LTC4S) |
PCRI: | 104023705 104026317(LTC4S) |
PLET: | 104618568 104618722(LTC4S) |
EHS: | 104506972 104514579(LTC4S) |
PCAO: | 104042914 104045217 |
ACUN: | 113485203(LTC4S) 113485336 |
TALA: | 104357001 104357925 |
PADL: | 103915754 103915829 |
AFOR: | 103904395 103904398 |
ACHC: | 115334117 115334443 |
HALD: | 104317407 104317814(LTC4S) |
HLE: | 104838888 104838891(LTC4S) |
AGEN: | 126050921 126050997 |
CCRI: | 104159890 104167057 |
CSTI: | 104552782 104557875(LTC4S) |
CMAC: | 104475127(LTC4S) 104487068 |
MUI: | 104536213(LTC4S) 104540151 |
BREG: | 104637945(LTC4S) 104638529 |
GSTE: | 104254183 104263209(LTC4S) |
LDI: | 104345659(LTC4S) 104349351 |
NNT: | 104398993 104400966(LTC4S) |
SHAB: | 115616165 115616170 |
DPUB: | 104296163 104310331 |
PGUU: | 104464903(LTC4S) 104470215 |
ACAR: | 104518195 104525810 |
CPEA: | 104386512 104386891 |
AVIT: | 104274425(LTC4S) 104274752 |
CVF: | 104293106 104293108(LTC4S) |
CUCA: | 104059369 104059405 |
BRHI: | 104497725(LTC4S) 104499775 |
AROW: | 112964865(LTC4S) 112964888 |
DNE: | 112996911(LTC4S) 112996946 |
SCAM: | 104142294 104142559 |
AMJ: | 102568686(LTC4S) 102571710 |
CPOO: | 109310147 109310151 |
CCAY: | 125640880 125641150(LTC4S) |
CPIC: | 101945657 101946405 |
CABI: | 116820058 116820064 |
XLA: | 108712616(ltc4s.1.S) 495166(ltc4s.2.L) |
XTR: | 100127769(ltc4s.2) 100379825(ltc4s.1) |
RTEM: | 120932527 120932530 |
BBUF: | 120986977 121008406(LTC4S) |
BGAR: | 122926480(LTC4S) 122928284 |
SANH: | 107660445 107667453 |
SGH: | 107551000(ltc4s) 107578450 |
CCAR: | 109081382 109102539 |
CAUA: | 113113366 113113488 |
CGIB: | 127971302 127971303 128026932 |
MASI: | 127412860 127417542 |
TBEN: | 117486846 117486852 |
PPRL: | 129354342 129360583 |
CCLU: | 121535800 121537030 123490828 |
PSPA: | 121296961 121323789 |
ARUT: | 117413502 117431402 |
LCM: | 102356667(LTC4S) 102366002 |
» show all
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Reference |
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Authors |
Bach MK, Brashler JR, Morton DR Jr. |
Title |
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase. |
Journal |
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Reference |
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Authors |
Shimizu T. |
Title |
Enzymes functional in the syntheses of leukotrienes and related compounds. |
Journal |
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Reference |
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Authors |
Lam BK, Austen KF. |
Title |
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes. |
Journal |
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Reference |
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Authors |
Christmas P, Weber BM, McKee M, Brown D, Soberman RJ. |
Title |
Membrane localization and topology of leukotriene C4 synthase. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 4.4.1.20 |
ExPASy - ENZYME nomenclature database: | 4.4.1.20 |
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