KEGG   ENZYME: 4.4.1.38
Entry
EC 4.4.1.38                 Enzyme                                 
Name
isethionate sulfite-lyase;
islA (gene name)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
isethionate sulfite-lyase
Reaction(IUBMB)
isethionate = acetaldehyde + sulfite [RN:R12763]
Reaction(KEGG)
R12763
Substrate
isethionate [CPD:C05123]
Product
acetaldehyde [CPD:C00084];
sulfite [CPD:C00094]
Comment
The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, participates in a taurine degradation pathway that leads to sulfide production. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster.
History
EC 4.4.1.38 created 2021
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K25261  isethionate sulfite-lyase
Genes
PWA: Pecwa_3461
PPAR: A8F97_01320
PEC: W5S_3597
PWS: A7983_13280
PCAC: OI450_00875
BGJ: AWC36_05935
BNG: EH206_07475
BIZ: HC231_15860
SLIG: GTU79_10120
DDS: Ddes_1436
DFI: AXF13_05515
DPG: DESPIGER_1590
DEF: CNY67_06110
DDE: Dde_1273
DPI: BN4_11150
PPRF: DPRO_3546
PTHE: LF599_13280
PBIZ: LWC08_09755
DVU: DVU_2824
DVL: Dvul_0491
DVG: Deval_2606
CLIH: KPS_000048
DBA: Dbac_1587
DESU: NLA06_05930
DPS: DP3027
DEO: CAY53_09700
PBD: PBOR_26450
CPAS: Clopa_0943
DSY: DSY0416
DHD: Dhaf_0366
DDH: Desde_0364
DRM: Dred_2750
DRU: Desru_0475
DFG: B0537_01450
DKU: Desku_2520
ABUT: Ami103574_01305
MANA: MAMMFC1_01805(bssA_1) MAMMFC1_01806(bssA_2)
STED: SPTER_02740(cutC_1) SPTER_04740(cutC_2)
 » show all
Reference
1  [PMID:30718429]
  Authors
Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D.
  Title
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.
  Journal
Proc Natl Acad Sci U S A 116:3171-3176 (2019)
DOI:10.1073/pnas.1815661116
Reference
2  [PMID:30962433]
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
  Sequence
[dvu:DVU_2824]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.38
IUBMB Enzyme Nomenclature: 4.4.1.38
ExPASy - ENZYME nomenclature database: 4.4.1.38
BRENDA, the Enzyme Database: 4.4.1.38

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (254)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (40)   
   KEGG MGENES (213)   
Protein sequence (8)   
   UniProt (4)   
   SWISS-PROT (4)   
Protein domain (4)   
   InterPro (4)   
All databases (274)   

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