KEGG   ENZYME: 4.6.1.26
Entry
EC 4.6.1.26                 Enzyme                                 
Name
uridylate cyclase;
pycC (gene name) (ambiguous)
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
Sysname
UTP diphosphate-lyase (cyclizing; 3',5'-cyclic-UMP-forming)
Reaction(IUBMB)
UTP = 3',5'-cyclic UMP + diphosphate [RN:R12998]
Reaction(KEGG)
R12998
Substrate
UTP [CPD:C00075]
Product
3',5'-cyclic UMP [CPD:C22509];
diphosphate [CPD:C00013]
Comment
The enzyme, found in bacteria and archaea, forms cUMP, which functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.
History
EC 4.6.1.26 created 2022
Reference
1  [PMID:34644530]
  Authors
Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R.
  Title
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.
  Journal
Cell 184:5728-5739.e16 (2021)
DOI:10.1016/j.cell.2021.09.031
Other DBs
ExplorEnz - The Enzyme Database: 4.6.1.26
IUBMB Enzyme Nomenclature: 4.6.1.26
ExPASy - ENZYME nomenclature database: 4.6.1.26
BRENDA, the Enzyme Database: 4.6.1.26

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Protein sequence (88)   
   UniProt (9)   
   SWISS-PROT (9)   
   RefSeq(pep) (70)   
DNA sequence (1756)   
   RefSeq(nuc) (1756)   
Protein domain (2)   
   InterPro (2)   
All databases (1850)   

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