KEGG   ENZYME: 4.6.1.6
Entry
EC 4.6.1.6                  Enzyme                                 
Name
cytidylate cyclase;
3',5'-cyclic-CMP synthase;
cytidylyl cyclase;
cytidyl cyclase;
CTP diphosphate-lyase (cyclizing);
pycC (gene name) (ambiguous)
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
Sysname
CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)
Reaction(IUBMB)
CTP = 3',5'-cyclic CMP + diphosphate [RN:R00574]
Reaction(KEGG)
R00574
Substrate
CTP [CPD:C00063]
Product
3',5'-cyclic CMP [CPD:C00941];
diphosphate [CPD:C00013]
Comment
In bacteria and archaea the enzyme's product, cCMP, functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.
History
EC 4.6.1.6 created 1989
Reference
1  [PMID:23778]
  Authors
Cech SY, Ignarro LJ.
  Title
Cytidine 3',5'-monophosphate (cyclic CMP) formation by homogenates of mouse liver.
  Journal
Biochem Biophys Res Commun 80:119-25 (1978)
DOI:10.1016/0006-291X(78)91112-9
Reference
2
  Authors
Newton, R.P., Salih, S.G., Hakeem, N.A., Kingston, E.E. and Beynon, J.H.
  Title
3',5'-Cyclic UMP, -cyclic IMP, -cyclic TMP and related enzymes in mammalian tissues.
  Journal
Biochem Soc Trans 13:1134-1135 (1985)
Reference
3  [PMID:34644530]
  Authors
Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R.
  Title
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.
  Journal
Cell 184:5728-5739.e16 (2021)
DOI:10.1016/j.cell.2021.09.031
Other DBs
ExplorEnz - The Enzyme Database: 4.6.1.6
IUBMB Enzyme Nomenclature: 4.6.1.6
ExPASy - ENZYME nomenclature database: 4.6.1.6
BRENDA, the Enzyme Database: 4.6.1.6
CAS: 65357-82-6

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