KEGG ENZYME: 4.99.1.11

ENZYME: 4.99.1.11

Entry

EC 4.99.1.11                Enzyme

Name

sirohydrochlorin nickelchelatase;
cfbA (gene name)

Class

Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses

Sysname

Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)

Reaction(IUBMB)

Ni-sirohydrochlorin + 2 H+ = sirohydrochlorin + Ni2+ [RN:R11626]

Reaction(KEGG)

R11626

Substrate

Ni-sirohydrochlorin [CPD:C21510];
H+ [CPD:C00080]

Product

sirohydrochlorin [CPD:C05778];
Ni2+ [CPD:C19609]

Comment

The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin.

History

EC 4.99.1.11 created 2017

Pathway

ec00860

Porphyrin metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

ec01120

Microbial metabolism in diverse environments

Orthology

K22011

sirohydrochlorin cobalto/nickelchelatase

Genes

TDU:	QJT80_05650

LLH:	I41_29610(cbiX)

MJA:

MJ_0970

MFE:	Mefer_0855

MVU:	Metvu_0528

MFS:	MFS40622_1021

MIF:	Metin_1283

MJH:	JH146_1257

MESG:

MLAUSG7_0577(cbiX)

MESA:

MLASG1_0218(cbiX)

MIG:	Metig_0269

MMP:	MMP0164(cbiX(s))

MMQ:	MmarC5_1511

MMX:	MmarC6_0786

MMZ:	MmarC7_1164

MMD:

GYY_00840

MMAK:

MMKA1_01690(cbiX)

MMAO:

MMOS7_01950(cbiX)

MMAD:

MMJJ_09200(cbiX)

MAE:

Maeo_1381

MVN:	Mevan_1169

MVO:

Mvol_1554

MOK:	Metok_0650

METF:

CFE53_04845

MTH:

MTH_1397

MMG:	MTBMA_c17830(cbiX)

MWO:	MWSIV6_1777(cbiX)

MTEE:

MTTB_15860

METC:

MTCT_1270

METE:

tca_01350(cbiX)

METZ:

METMT2_0062

METK:

FVF72_04600(cfbA)

MTHM:

FZP57_08700(cfbA)

METJ:

FZP68_02025(cfbA)

MST:	Msp_1563(cbiX)

METB:

AW729_07475

MEIS:

PXD04_03550(cfbA)

MSI:

Msm_1281

MEB:	Abm4_0618(cbiX1)

MMIL:

sm9_2307(cbiX1)

MEYE:

TL18_00210

MARO:

MarbSA_12130

METV:

K4897_04930(cfbA)

MEL:	Metbo_0181

MEW:	MSWAN_2302

METH:

MBMB1_1943

MFC:	BRM9_0750(cbiX) BRM9_2283

MFI:	DSM1535_0709 DSM1535_1217

MCUB:

MCBB_2224(cbiX)

MSUB:

BK009_08975

METN:

BK008_04595

METT:

CIT01_05355 CIT01_09230

METO:

CIT02_07815 CIT02_10385

MEME:

HYG87_06215(cfbA)

MFEG:

GCM10025860_05960 GCM10025860_15770

MFV:

Mfer_0962

MKA:

MK0428

MBA:	Mbar_A0344 Mbar_A2400

MBY:	MSBRM_0575

MBW:	MSBRW_0653 MSBRW_2346

MBAR:

MSBR2_1804

MBAK:

MSBR3_2859

MAC:	MA_3631(cbiX)

MMA:

MM_0517

MMAZ:

MmTuc01_0537

MMJ:	MSMAS_0789

MMAC:

MSMAC_0768

MVC:	MSVAZ_3049

MEK:	MSKOL_2989

MLS:	MSLAZ_2302

METM:

MSMTP_0889 MSMTP_0890

MEF:	MSWH1_2455

MEQ:	MSWHS_2588

MSJ:	MSSAC_1168 MSSAC_1225

MSZ:	MSSIH_1080 MSSIH_2811

MSW:	MSSIT_1127 MSSIT_2845

MTHR:

MSTHT_2448

MTHE:

MSTHC_0834

MHOR:

MSHOH_0892

MFZ:	AOB57_003185(cfbA)

MBU:	Mbur_1035(cbiXS)

MMET:

MCMEM_1517

MELO:

J7W08_06395(cfbA)

MMH:

Mmah_1410

MHAZ:

BHR79_06625

MPOT:

BKM01_02870

MEV:	Metev_0558

MZH:	Mzhil_0471

MPY:

Mpsy_2755

MZI:	HWN40_08895(cfbA)

MMAV:

RE476_01290(cfbA)

MSEB:

RE474_10980(cfbA)

MHZ:	Metho_0734

MEHF:

MmiHf6_00840

MEES:

MmiEs2_09210

MTP:

Mthe_0104

MCJ:	MCON_1928(cbiX)

MHI:

Mhar_2389

MHU:

Mhun_0668

MRTJ:

KHC33_10030(cfbA)

MLA:	Mlab_0518 Mlab_1086

MEM:	Memar_1731

MBG:	BN140_0720(cbiX)

MCHK:

MchiMG62_19330

MSUM:

OH143_02885(cfbA)

MRC:	R6Y96_04915(cfbA)

MPI:

Mpet_1000

MEND:

L6E24_12105(cfbA)

MEFW:

F1737_06060(cfbA)

MAQE:

RJ40_03905(cfbA)

MFK:	E2N92_04060(cfbA)

MOU:	OU421_12225(cfbA)

MESB:

L1S32_04105(cfbA)

MANQ:

L1994_05920(cfbA)

MBN:

Mboo_1417

MFO:	Metfor_1750

MPL:

Mpal_0681

MPD:	MCP_0361(cbiX-1)

MEZ:	Mtc_0061(cbiX)

RCI:	RCIX2006(cbiX-1)

MELU:

MTLP_03870

MEAM:

MU439_05090(cfbA)

MEAE:

QEN48_05065(cfbA)

MER:	MMINT_17250

MEAR:

Mpt1_c07010(cbiX1) Mpt1_c08040(cbiX2)

» show all

Reference

1 [PMID:27846569]

Authors

Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO

Title

The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.

Journal

Science 354:339-342 (2016)
DOI:10.1126/science.aag2947

Sequence

[mac:MA_3631]

Other DBs

ExplorEnz - The Enzyme Database:

4.99.1.11

IUBMB Enzyme Nomenclature:

4.99.1.11

ExPASy - ENZYME nomenclature database:

4.99.1.11

BRENDA, the Enzyme Database:

4.99.1.11

DBGET integrated database retrieval system