Entry
Name
pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase;
LarC;
P2TMN nickel chelatase
Class
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
BRITE hierarchy
Sysname
Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide nickel-lyase (pyridinium-3,5-bisthiocarboxylate-mononucleotide-forming)
Reaction(IUBMB)
Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = pyridinium-3,5-bisthiocarboxylate mononucleotide + Ni2+ [RN:
R11921 ]
Reaction(KEGG)
Substrate
Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide [CPD:
C21769 ]
Product
pyridinium-3,5-bisthiocarboxylate mononucleotide [CPD:
C21767 ];
Ni2+ [CPD:
C19609 ]
Comment
This enzyme, found in Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It catalyses the insertion of Ni2+ into the cofactor forming a covalent bond between a carbon atom and the nickel atom.
History
EC 4.99.1.12 created 2017
Orthology
K09121 pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase
Genes
BUM : AXG89_23670 AXG89_29020
SINL : DSM14862_03968(larC)
GEF : FO488_15685(larC) FO488_17530
GBN : GEOBRER4_19860 GEOBRER4_35270
DMS : E8L03_07250(larC) E8L03_17245
DTI : Desti_4488 Desti_5194
BWH : A9C19_14250 A9C19_14255
BCOH : BC6307_01210 BC6307_01215
BMH : BMWSH_1761 BMWSH_1762
PKS : IE339_08245 IE339_08250
BKW : BkAM31D_16110 BkAM31D_16115
CFIR : NAF01_22305 NAF01_22315
OCN : CUC15_13685 CUC15_13695
GJF : M493_05020 M493_05025
GSR : GS3922_11535 GS3922_11540
ASED : IRT44_02110 IRT44_02120
HMN : HM131_18275 HM131_18315
HNZ : P9989_17365 P9989_17370(larC)
VNT : OLD84_03700 OLD84_03830
VIK : KFZ58_03095 KFZ58_03190
FEC : QNH15_22260 QNH15_22345
PBUT : DTO10_00740 DTO10_00745
GRC : GI584_21910 GI584_22025(larC)
POF : GS400_06180 GS400_06220
NMK : CHR53_07495 CHR53_07500
NDT : L1999_05500 L1999_10845(larC)
NCM : QNK12_05685 QNK12_05690
MSEM : GMB29_07380 GMB29_07385
BAGR : BA6348_07445 BA6348_07455
BCHS : JNE38_25845(larC) JNE38_25860
BCOP : JD108_04900 JD108_04905
BAYD : BSPP4475_03720 BSPP4475_03730(larC)
BRUM : NDK47_05735 NDK47_05745
PMS : KNP414_03618 KNP414_03619
PMQ : PM3016_1025 PM3016_1026
PAEJ : H70737_15675 H70737_15680
PNP : IJ22_32600 IJ22_32610
PPSC : EHS13_07735 EHS13_07745
PPOG : QPK24_13755 QPK24_13760
COH : EAV92_16185 EAV92_16190
COHN : KCTCHS21_47960 KCTCHS21_48040
AACO : K1I37_09610(larC) K1I37_09635
SPAE : E2C16_10305 E2C16_10350(larC)
SURL : BI350_14325 BI350_14505
LCW : BN194_P0240 BN194_P0250(larC2)
LPL : lp_0106(larC1) lp_0107(larC2)
LPT : zj316_0315(larC1) zj316_0316(larC2)
LPS : LPST_C0087 LPST_C0088
LPB : SH83_00455 SH83_00460
LPX : ASU28_03260 ASU28_03265
LPG : BB562_00445 BB562_00450
LARG : LPA65_00485 LPA65_00490
LNG : BSQ50_05845 BSQ50_10050
LBT : AYR52_09965 AYR52_09970
LCY : LC20004_11465 LC20004_11470
LCV : FBA2_04105 FBA2_04110
LGM : LG542_05670 LG542_05675 LG542_08125(larC)
EGV : EGCR1_11150(larC) EGCR1_12080(larC)
AUN : AWM73_01170 AWM73_01175
ALOY : CJ190_001310 CJ190_001315
ATJ : DBT50_007390 DBT50_007395
CDRK : B9W14_10665 B9W14_25280
CFER : D4Z93_06660(larC) D4Z93_07790(larC)
RUK : A4V00_04010 A4V00_06810
DOR : Desor_0621 Desor_2618 Desor_3245
DCA : Desca_1935 Desca_2736
DFG : B0537_00595 B0537_01560
TFR : BR63_18635 BR63_18675(larC)
HCV : FTV88_0843 FTV88_0844
EMT : CPZ25_000635(larC) CPZ25_014830(larC)
ELIM : B2M23_01610 B2M23_11065
AWO : Awo_c23030 Awo_c32360
AWI : CHL1_002278(larC) CHL1_003436(larC)
BHAN : CGC63_04450 CGC63_08100
BLAU : DQQ01_06735 DQQ01_08445
BLIQ : INP51_07425 INP51_10645
BLUI : Blut17040_08420(larC)
CSCI : HDCHBGLK_02409 HDCHBGLK_02628
ARF : AR1Y2_0542 AR1Y2_0543
ANR : Ana3638_00620 Ana3638_10445(larC)
VGU : HYG85_02370 HYG85_13530(larC)
AMIJ : EQM06_00135 EQM06_02300(larC)
AMIC : Ami3637_04845(larC)
ABUT : Ami103574_00900 Ami103574_03970(larC)
ETM : CE91St48_13530 CE91St48_13770
PBIF : KXZ80_14840 KXZ80_14845(larC)
PSOR : RSJ16_16630 RSJ16_16635
ROC : HF520_12240 HF520_12245(larC)
TEB : T8CH_0212(larC) T8CH_0213(larC)
IBR : NQ514_02535(larC) NQ514_02540
TMT : Tmath_0780 Tmath_0781
TBO : Thebr_1573 Thebr_1574
TKI : TKV_c07460 TKV_c07470
AAR : Acear_0266 Acear_1786
CDAN : SOJ16_001602(larC) SOJ16_001603
MHW : ACT01_01310 ACT01_13345
MEG : DKB62_05935 DKB62_08920
MFUN : GXM21_00890 GXM21_05060
STED : SPTER_16680(larC_1) SPTER_37050(larC_2)
FIT : Fi14EGH31_12970 Fi14EGH31_12980
CALK : HUE98_04210 HUE98_04215(larC)
CAER : CSV91_06605 CSV91_09300
SLE : sle_12230(sle_12230)
RAIN : Rai3103_03785(larC)
PSUU : Psuf_061400 Psuf_089220
SYY : SYNGTS_0157(slr1411)
SYT : SYNGTI_0157(slr1411)
SYS : SYNPCCN_0157(slr1411)
SYQ : SYNPCCP_0157(slr1411)
PSER : ABRG53_3379 ABRG53_3380
PGX : OA858_11625(larC) OA858_11630
CWA : CwatDRAFT_6650 CwatDRAFT_6651
NSPH : BDGGKGIB_03001(larC)
ABAO : BEQ56_04745 BEQ56_08290
KBB : ccbrp13_24090 ccbrp13_47850
CCZ : CCALI_00583 CCALI_02746
BROC : IPI25_06850 IPI25_06855
PHM : PSMK_12040 PSMK_18840
PCOR : KS4_05820 KS4_22810
CPOR : BED41_01335 BED41_05340
PPIO : CE91St28_16230 CE91St28_21480
PYY : RAH42_05520 RAH42_11450
ARAM : KAR29_00345 KAR29_10105
MMAK : MMKA1_02750 MMKA1_08640
MMAO : MMOS7_03030 MMOS7_08540
MMAD : MMJJ_01910 MMJJ_07890
MVN : Mevan_0274 Mevan_1281
MMET : MCMEM_0414 MCMEM_1199
MCHK : MchiMG62_01820 MchiMG62_24780
MRC : R6Y96_01110 R6Y96_10095(larC)
MPI : Mpet_0163 Mpet_1113 Mpet_1898
MAQE : RJ40_05750(larC) RJ40_06645(larC)
MFK : E2N92_05885(larC) E2N92_06795(larC)
MOU : OU421_01390 OU421_09545(larC)
HALA : Hrd1104_08635(larC)
HALQ : Hrr1229_013855(larC)
HACB : Hbl1158_13055(larC)
FLT : Sv326_0936 Sv326_0937
» show all
Taxonomy
Reference
Authors
Desguin B, Goffin P, Viaene E, Kleerebezem M, Martin-Diaconescu V, Maroney MJ, Declercq JP, Soumillion P, Hols P
Title
Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.
Journal
Sequence
Reference
Authors
Desguin B, Soumillion P, Hols P, Hausinger RP
Title
Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.99.1.12