KEGG   ENZYME: 4.99.1.8
Entry
EC 4.99.1.8                 Enzyme                                 
Name
heme ligase;
heme detoxification protein;
HDP;
hemozoin synthase
Class
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
Sysname
Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming)
Reaction(IUBMB)
2 ferriprotoporphyrin IX = beta-hematin
Substrate
ferriprotoporphyrin IX
Product
beta-hematin
Comment
This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin. These organisms lack the mammalian heme oxygenase for elimination of heme.
History
EC 4.99.1.8 created 2009
Orthology
K17949  heme ligase
Genes
PFA: PF3D7_1446800
PFD: PFDG_04534
PFH: PFHG_04214
PGAB: PGSY75_1446800
PYO: PY17X_1314400
PCB: PCHAS_1313900
PBE: PBANKA_1310600
PVV: PVVCY_1301220
PKN: PKNH_1235400
PVX: PVX_118155
PCY: PCYB_126830
PMAL: PMUG01_12070200(HDP)
PREL: PRELSG_1234200(HDP)
TAN: TA11080
TPV: TP04_0891
TOT: TOT_040000052
BEQ: BEWA_011450
BBO: BBOV_III009730
BBIG: BBBOND_0313490
 » show all
Reference
1  [PMID:18437218]
  Authors
Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D
  Title
HDP-a novel heme detoxification protein from the malaria parasite.
  Journal
PLoS Pathog 4:e1000053 (2008)
DOI:10.1371/journal.ppat.1000053
  Sequence
[pfa:PF3D7_1446800]
Other DBs
ExplorEnz - The Enzyme Database: 4.99.1.8
IUBMB Enzyme Nomenclature: 4.99.1.8
ExPASy - ENZYME nomenclature database: 4.99.1.8
BRENDA, the Enzyme Database: 4.99.1.8

  All links  
Gene (20)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (19)   
Protein sequence (7)   
   UniProt (4)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (10)   
   RefSeq(nuc) (4)   
   GenBank (3)   
   EMBL (3)   
Protein domain (3)   
   InterPro (3)   
All databases (40)   

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