Entry
Name
4-hydroxyproline betaine 2-epimerase;
hpbD (gene name);
Hyp-B 2-epimerase;
(4R)-4-hydroxyproline betaine 2-epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
BRITE hierarchy
Sysname
4-hydroxyproline betaine 2-epimerase
Reaction(IUBMB)
(1) trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine [RN:
R11630 ];
(2) L-proline betaine = D-proline betaine [RN:
R11631 ]
Reaction(KEGG)
Substrate
trans-4-hydroxy-L-proline betaine [CPD:
C08269 ];
L-proline betaine [CPD:
C10172 ]
Product
cis-4-hydroxy-D-proline betaine [CPD:
C21513 ];
D-proline betaine [CPD:
C21514 ]
Comment
The enzyme, characterized from the bacteria Pelagibaca bermudensis and Paracoccus denitrificans, specifically catalyses racemization of trans-4-hydroxy-L-proline betaine and L-proline betaine at the C-2 position.
History
EC 5.1.1.22 created 2017
Orthology
K21617 4-hydroxyproline betaine 2-epimerase
Genes
MDX : BTO20_21615 BTO20_21695
» show all
Taxonomy
Reference
Authors
Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP
Title
Discovery of new enzymes and metabolic pathways by using structure and genome context.
Journal
Reference
Authors
Kumar R, Zhao S, Vetting MW, Wood BM, Sakai A, Cho K, Solbiati J, Almo SC, Sweedler JV, Jacobson MP, Gerlt JA, Cronan JE
Title
Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.22
ExPASy - ENZYME nomenclature database: 5.1.1.22