KEGG ENZYME: 5.1.3.10

ENZYME: 5.1.3.10

Entry

EC 5.1.3.10                 Enzyme

Name

CDP-paratose 2-epimerase;
CDP-paratose epimerase;
cytidine diphosphoabequose epimerase;
cytidine diphosphodideoxyglucose epimerase;
cytidine diphosphoparatose epimerase;
cytidine diphosphate paratose-2-epimerase;
CDP-abequose epimerase (incorrect);
CDP-D-abequose 2-epimerase (incorrect);
CDP-tyvelose 2-epimerase,

Class

Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives

Sysname

CDP-3,6-dideoxy-D-glucose 2-epimerase

Reaction(IUBMB)

CDP-alpha-D-paratose = CDP-alpha-D-tyvelose [RN:R04266]

Reaction(KEGG)

R04266

Substrate

CDP-alpha-D-paratose [CPD:C03598]

Product

CDP-alpha-D-tyvelose [CPD:C03599]

Comment

Requires NAD+.

History

EC 5.1.3.10 created 1972, modified 2005

Pathway

ec00520

Amino sugar and nucleotide sugar metabolism

ec00541

O-Antigen nucleotide sugar biosynthesis

ec01100

Metabolic pathways

Orthology

K12454

CDP-paratose 2-epimerase

Genes

STY:	STY2298(rfbE)

STT:	t0784(rfbE)

SEX:	STBHUCCB_8360

SENT:

TY21A_03975

SPT:	SPA0778(rfbE)

SEK:	SSPA0732(rfbE)

SED:

SeD_A2428

SEG:

SG2119

SEL:	SPUL_0809(rfbE)

SEGA:

SPUCDC_0809(rfbE)

SET:	SEN2085C(rfbE)

SENA:

AU38_10535

SENO:

AU37_10545

SENV:

AU39_10545

SENQ:

AU40_11800

SENL:

IY59_10830

SENJ:

CFSAN001992_00985

SEEP:

I137_03635

YMO:	HRD69_10875

YEG:	PL78_00705

FSM:	CCS41_13935

XBU:	HGO23_18935

LSOL:

GOY17_06235

LAUX:

LA521A_11930

TCN:	H9L16_11300

PPEG:

KUA23_08620

SDK:	KHX94_02795

APEL:

CA267_007245

PIN:

Ping_0777

LCD:	clem_00985(rfbE)

LJR:	NCTC11533_02025(rmlB_2)

MMAI:

sS8_4814

MSZE:

MSZNOR_3929(rfbE)

AFRI:

E3E15_05595

TIG:

THII_1699

BLEP:

AL038_14615

NWR:	E3U44_15405

BSTG:

WT74_16865

TCAR:

U0034_02770 U0034_20325

VPE:	Varpa_3055

RTA:

Rta_16030

MIU:	ABE85_08525

GCA:

Galf_2844

GAGG:

Gromo_00455

MCI:	Mesci_5445

MCIC:

A4R28_30090

MOP:	Mesop_6535

MAM:	Mesau_05466

MESW:

A9K65_029705

MMEI:

LRP31_27610

MES:

Meso_2779

CHEA:

PVE73_04475

SME:	SM_b20244(tyv_OR_Smb20244)

SMK:	Sinme_3929

SMQ:	SinmeB_4426

SMX:	SM11_pD1367(tyv)

SMI:	BN406_06422(tyv)

SMEG:

C770_GR4pD1353

SMEL:

SM2011_b20244(tyv)

SMER:

DU99_32150

SMD:

Smed_3888

SFD:	USDA257_c51200(rfbE)

SAME:

SAMCFNEI73_Ch3083(rfbE)

SINO:

SS05631_c31260

ESJ:	SJ05684_b50780

EAK:	EKH55_5090

EMX:	FKV68_26800

ENU:	PYH37_002291

SKM:	PZL22_001014

STEG:

QA637_27805

RIR:	BN877_II1875

RET:	RHE_PB00053

REC:	RHECIAT_PC0000295

REL:	REMIM1_PA00060

REP:	IE4803_PD00366

REI:	IE4771_PE00381

RLG:

Rleg_5580

RLB:	RLEG3_32965

RGA:	RGR602_CH03301

RHN:	AMJ98_PE00169

RPHA:

AMC79_PD00317

RHX:	AMK02_PA00054

RHV:	BA939_16960

RHK:	Kim5_PD00342

REZ:	AMJ99_PD00170

RHR:	CKA34_26800

RAD:	CO657_35595

RHID:

FFM81_026115

RLN:	J0663_04755

RBAN:

J2J98_29640

RLW:	RlegWSM1455_22140

NEO:	CYG48_05775

RHT:

NT26_1836

RFV:	RFYW14_01915

PDES:

FE840_004970

BRA:

BRADO2068

BRC:	BCCGELA001_15165

BRAD:

BF49_5295

BRO:	BRAD285_5204(rfbE)

BGQ:	X265_08410

BVZ:	BRAD3257_5348(rfbE)

BCAN:

BcanWSM471_27870

BRAZ:

LRP30_24970

MEA:	Mex_1p0147

MDI:

METDI0135

MEX:	Mext_0250 Mext_0510

MCH:

Mchl_0196

MPO:

Mpop_1270

MRD:	Mrad2831_1321

MET:

M446_2077

MNO:

Mnod_0433

MEE:	DA075_12925

METD:

C0214_05555

METI:

DK427_15050

MMES:

MMSR116_02500

MTEA:

DK419_19920

MOG:	MMB17_00070

MTAD:

M6G65_09140

MICO:

GDR74_16155

MTEZ:

HPT29_003590

MLD:	U0023_10910

BBAR:

RHAL1_03203(rfbE)

CHEL:

AL346_19520

FIL:	BN1229_v1_1399(rfbE)

FIY:	BN1229_v1_1398(rfbE)

DRH:	JI748_09530

MSC:

BN69_3019

PLEO:

OHA_1_01494(rfbE)

MLUT:

JET14_08455

AUB:	LXB15_13680

JAV:	OXU80_02980

LABP:

FJ695_11020

LIZ:	LGH83_12840

PZU:

PHZ_c2088

BRD:	JL11_07055

CID:

P73_4351

CON:	TQ29_02260

RSP:

RSP_0519

RSH:	Rsph17029_2171 Rsph17029_3699

RSQ:	Rsph17025_2430

RSK:	RSKD131_1853 RSKD131_4168

CAZT:

LV780_11085

PYE:	A6J80_20395

PCON:

B0A89_13525

PARU:

CYR75_13150

PAAK:

FIU66_17805

PLIA:

E4191_16710

PSTL:

JHW45_17635

SPAN:

AWL63_22120

SPII:

G7077_06375

SARI:

H5J25_14620

SMOR:

LHA26_05120

SQO:	NMP03_13395

SCAB:

LZK98_18690

SRAD:

LLW23_08680

SJP:	SJA_C1-11160(rfbB)

SINB:

SIDU_08660

SYB:	TZ53_21575

SPMI:

K663_04900

SUFL:

FIL70_10755

SBAR:

H5V43_08490

SPHJ:

BSL82_06095

SPHS:

ETR14_09865

ALB:

AEB_P1943

ROS:	CTJ15_01330

RMT:	IAI58_17285

LCK:	HN018_16770

RAP:

RHOA_5752

SHUM:

STHU_14620 STHU_14630

SVC:	STVA_38620 STVA_38630

STEL:

STAQ_11090 STAQ_11100

ALI:	AZOLI_p50348(rfbE)

ABS:	AZOBR_p210161 AZOBR_p210164 AZOBR_p60050 AZOBR_p60051

ABQ:	ABAZ39_23815 ABAZ39_23830

ABF:	AMK58_22015 AMK58_22030 AMK58_29225 AMK58_29230

AZT:	TSH58p_02840 TSH58p_02855 TSH58p_18140 TSH58p_18145

AZM:	DM194_24705

AZZ:	DEW08_18670

AOZ:	HUE56_00345

AARE:

D3093_26675 D3093_26690

AZS:	E6C72_29005 E6C72_31040

SKT:	IGS68_07555 IGS68_17820 IGS68_17830

SMUC:

JL100_008180 JL100_008190 JL100_020065

SROE:

JL101_008065 JL101_008075 JL101_018810

RCE:	RC1_0527(rfbE)

MAGX:

XM1_1573 XM1_1574

MAGN:

WV31_15880 WV31_15885

MAG:	amb3785 amb3786

NACI:

NUH88_13490

TMO:	TMO_a0325(rfbE)

MGM:	Mmc1_2871 Mmc1_2872

APC:	HIMB59_00014910

SULC:

CVO_08540

SAQT:

GJV85_09690

CCOC:

CCON33237_0123

HYO:

NNO_0327

GEM:

GM21_2537

GEF:	FO488_01050

GUR:

Gura_3786

GEO:	Geob_2128(tyv) Geob_3241

GBM:	Gbem_0859(tyv) Gbem_1684

GBN:	GEOBRER4_24780

GER:	KP004_11765

GSUB:

KP001_03400

GPL:	M1B72_08320

DMA:	DMR_38130 DMR_38140

DCB:	C3Y92_03590 C3Y92_03595

DAF:	Desaf_1146 Desaf_1351

DEJ:	AWY79_10410

PPOR:

JCM14722_22310

DOL:

Dole_0520

DALK:

DSCA_06670

DTI:	Desti_4499

ADE:	Adeh_1061 Adeh_4298

ACP:	A2cp1_1189

AFW:	Anae109_3217

ANK:	AnaeK_1120

AORY:

AMOR_10810

APAU:

AMPC_05950

MXA:	MXAN_1639(rfbE)

MYX:	QEG98_09275

CCX:	COCOR_01687(rfbE)

MFU:	LILAB_00525

MMAS:

MYMAC_001762

AVM:	JQX13_06785 JQX13_36685 JQX13_36690

MBD:	MEBOL_002337

CFUS:

CYFUS_003878 CYFUS_003879 CYFUS_009178

SCL:	sce6772 sce8935(galE6)

SCU:	SCE1572_39725 SCE1572_51015

PAUU:

E8A73_002600

MRM:	A7982_02004 A7982_05838

SAMY:

DB32_001205

PCAY:

FRD00_19535

BMX:	BMS_0380(rfbE)

PBK:	Back11_31800

PALO:

E6C60_1121

PAUN:

MJA45_07430

COH:	EAV92_06975

CCE:

Ccel_0969

DGI:	Desgi_4708

MCOO:

MCOO_26540(rfbE)

SINN:

ABB07_18125

STRH:

GXP74_17580

APRE:

CNX65_14865

AMI:

Amir_2951

SSYI:

EKG83_14875 EKG83_31880

STP:	Strop_0041

SAQ:

Sare_0046

MAU:	Micau_0093

MIL:

ML5_0076

MICB:

MicB006_0084

MTUA:

CSH63_25580

MICH:

FJK98_00360

MTEM:

GCE86_25930

MCAB:

HXZ27_00290

MSAG:

GCM10017556_26630

VMA:	VAB18032_04800

MCRA:

ID554_14110

VER:	HUT12_00325

MENO:

Jiend_27840

MCHL:

PVK74_21475

MFEU:

H1D33_07255

MPRN:

Q3V37_06660

MHAW:

RMN56_11290

ASE:

ACPL_6844

AMS:	AMIS_65950

ACTN:

L083_0049

AFS:

AFR_00260

ACTS:

ACWT_6714

AIH:	Aiant_26720

ACTR:

Asp14428_46670

ACTL:

L3i22_091360

ASIC:

Q0Z83_103920

AOU:	ACTOB_007156

PLK:	CIK06_00430

PLAB:

C6361_17250

PLAT:

C6W10_34340

ATL:	Athai_57920

ASER:

Asera_17100

PRY:	Prubr_24400

CATI:

CS0771_12420

DVC:	Dvina_00260

DFU:	Dfulv_00335

DROS:

Drose_00250

DAUR:

Daura_00280

DMAT:

Dmats_00270

NHY:	JQS43_25535

CCAZ:

COUCH_00760

SNA:

Snas_0259

BSOL:

FSW04_00720

PARN:

NBH00_02360 NBH00_02365

PBAJ:

LRS13_19750

AYM:	YM304_22180

ATQ:	GH723_12350

IAM:	HC251_08360

IMA:	PO878_07695

SYJ:	D082_21370

SYNE:

Syn6312_0747

CGC:	Cyagr_1211 Cyagr_2189

CYI:	CBM981_2621(rfbE)

PMM:

PMM1201

CYN:	Cyan7425_0420 Cyan7425_0423 Cyan7425_1267

AMR:

AM1_G0129

LBO:	LBWT_55510

LSK:	J5X98_02940 J5X98_02950

HHG:	XM38_013790

PSEU:

Pse7367_3618 Pse7367_3619

CHON:

NIES4102_32980 NIES4102_38220

GEN:	GM3709_1319 GM3709_1323

MAR:	MAE_46390 MAE_46430

MPK:	VL20_5994 VL20_5997

MIQ:	B5D77_24475 B5D77_24485

MVZ:	myaer102_20070 myaer102_20100

CWA:	CwatDRAFT_3477

CYJ:	Cyan7822_3234 Cyan7822_3235

ARP:	NIES39_A00610

OXY:	HCG48_13540

MVAG:

D0A34_13385 D0A34_22230

ONI:	Osc7112_0103 Osc7112_4264

PHOR:

JWS08_07235 JWS08_07245

PYH:	NEA10_03525 NEA10_03535

MIC:	Mic7113_2162

GVI:

glr1179

GLJ:	GKIL_1591(rfbE) GKIL_4274

GML:	ISF26_01285

NPZ:	ACX27_13425

AVA:	Ava_3352 Ava_3353

ANB:	ANA_C13063

AWA:	AA650_04425

ANN:	EH233_06480 EH233_06485

HBQ:	QI031_20025

CALO:

Cal7507_0376

CALN:

NIES2098_60640

CALS:

NIES3974_45180

NSP:	BMF81_04458(rfbE) BMF81_04459(rfbE_2)

NSPH:

BDGGKGIB_04337(rfbE_1) BDGGKGIB_04341(rfbE_2)

DOU:	BMF77_03076(rfbE_1) BMF77_03080(rfbE_2)

DHT:	NG743_12980 NG743_12995

CCUR:

IAR63_02080 IAR63_16530 IAR63_17095

CRK:	L3I90_05470 L3I90_08715

AFLO:

HEQ12_06735

RCS:	NIES932_19650

TOQ:	HCG51_15615 HCG51_15620 HCG51_15705 HCG51_15720

NCN:	BZZ01_04690 BZZ01_26920

CTHE:

Chro_1106 Chro_1109 Chro_2364 Chro_4810

SCS:	Sta7437_1461

STAN:

STA3757_40270

GLT:	GlitD10_2962(rfbE)

CAU:

Caur_1745

CHL:	Chy400_1889

CAG:	Cagg_1989 Cagg_2762

PSUB:

Pelsub_P1573

LEK:	hrd7_29830

ABAO:

BEQ56_06695

CAP:	CLDAP_10430 CLDAP_10460(galE)

PBF:	CFX0092_A1594(rfbE)

THUG:

KNN16_14140

DGE:

Dgeo_2646

DAH:	DAETH_41140

TTS:	Ththe16_0979

CCZ:	CCALI_02423

FGI:	OP10G_3322

VAB:	WPS_29430 WPS_29440

OTE:	Oter_3986 Oter_3990

OBG:	Verru16b_02012(rfbE_1) Verru16b_02015(rfbE_2)

OLE:	K0B96_03860 K0B96_04545

SLOM:

PXH66_11135 PXH66_11155

ELUT:

CKA38_05795

RUFI:

K0V07_03675

ROO:	G5S37_01135 G5S37_26580

VEG:	SAMN05444156_0104

FPES:

NXS98_17480

VBA:	IMCC26134_03185 IMCC26134_08260 IMCC26134_11905

RBA:	RB7482(rfbE) RB8904(tyv)

RUL:	UC8_39750(rfbE)

RML:	FF011L_41660(rfbE)

MFF:	MFFC18_31990(rfbE)

ROL:	CA51_25980(rfbE)

RUV:	EC9_28470(rfbE_1) EC9_31190(rfbE_2)

RLC:	K227x_00290(rfbE_1) K227x_06680(rfbE_2)

SMAM:

Mal15_05230(rfbE_1) Mal15_28680(rfbE_2)

SNEP:

Enr13x_29930(rfbE_1) Enr13x_70570(rfbE_2)

LPAV:

PLANPX_2619

AMUC:

Pan181_22850(rfbE)

AMOB:

HG15A2_22890(rfbE)

FMR:	Fuma_05606(rfbE_1) Fuma_05609(rfbE_2)

GMR:	GmarT_46430(rfbE_1) GmarT_46450(rfbE_2)

ACAF:

CA12_07740(rfbE)

CHYA:

V22_39980(rfbE_1) V22_39990(rfbE_2)

CCOP:

Mal65_01080(rfbE)

IPA:	Isop_1615 Isop_3763

SACI:

Sinac_3894

BROC:

IPI25_09915 IPI25_09920

PHM:	PSMK_00110

VAI:	BU251_04330

LBJ:

LBJ_0629

LBL:

LBL_2450

LBI:	LEPBI_II0120

LBF:

LBF_4117

LST:

LSS_06934

LAJ:	A0128_02855

LMAY:

DPV73_08855

LKM:	EFP84_13685

LWL:	FHG68_03500

LKB:	LPTSP3_g20880 LPTSP3_g20890 LPTSP3_g37840

TPX:	Turpa_0300 Turpa_0302

ABA:	Acid345_3495

TSA:	AciPR4_1873

TRS:	Terro_1884

ABAS:

ACPOL_5365

ADIN:

H7849_03535

ORP:	MOP44_13570

SUS:	Acid_0286 Acid_0287 Acid_3011

PFER:

IRI77_14595 IRI77_14600

CTM:	Cabther_A1238 Cabther_B0600 Cabther_B0601

CVL:	J8C06_14820 J8C06_14825

CHLO:

J8C02_06010 J8C02_11605 J8C02_11610

ABAC:

LuPra_04958(rfbE_1) LuPra_04961(rfbE_2)

EPO:	Epro_0330(rfbE)

CSOM:

MKD34_00830

BFS:	BF9343_2519(rfbE)

BFG:	BF638R_3482

BFB:	VU15_06465 VU15_11510 VU15_16410

BEG:	INE88_03490(rfbE)

PPN:	Palpr_0967

DRC:	G0Q07_02770

FLS:	GLV81_17870

LACS:

H4075_02055 H4075_02060

PEJ:	FYC62_06320

MUP:	A0256_22850

MGIK:

GO620_005205

MROB:

HH214_13615

MJJ:	PQO05_07790

SLI:	Slin_2975 Slin_5183 Slin_6291 Slin_6411

SRD:	SD10_15860 SD10_21310 SD10_26090

SMON:

AWR27_00255 AWR27_21185

SPIR:

CWM47_14810 CWM47_25525

SPIK:

EXU85_09755 EXU85_33055

SPIB:

G8759_02995 G8759_17885

STAE:

HNV11_04440 HNV11_22280

SRHO:

HH216_09195 HH216_18240 HH216_20235

SOQ:	LQ777_00945 LQ777_14295

SFOL:

H3H32_19510 H3H32_31630

SENF:

GJR95_00730 GJR95_11000

RHOZ:

GXP67_10895

PSEZ:

HME7025_00129(rfbB) HME7025_00130(rfbE)

DFE:	Dfer_3530 Dfer_4399 Dfer_4599

DSN:	HWI92_04920 HWI92_15785 HWI92_18725

DYC:	NFI80_15155 NFI80_19320

DFQ:	NFI81_16310 NFI81_20470

DCN:	MUK70_20140 MUK70_24430

DPF:	ON006_24110 ON006_28655 ON006_29870

RSI:	Runsl_1529 Runsl_2293

RUN:	DR864_16535 DR864_19785

RUP:	DTQ70_20665 DTQ70_25350

EOL:	Emtol_1550 Emtol_2529

EMZ:	MB380_20555 MB380_21745

FAE:	FAES_0743 FAES_1099

FIB:	A6C57_10135 A6C57_10505

ALS:	DJ013_05925 DJ013_07450

MAQA:

LAG90_08115 LAG90_15125

HNV:	DDQ68_04535 DDQ68_04540

HYJ:	FHG12_18385

HMT:	MTP16_01865 MTP16_01870

PKO:	PKOR_00265

PACT:

CA264_12140

RTI:	DC20_03940

ADD:	HUW48_14705

FBT:	D770_00415

PPSV:

PEPS_40150

FPAL:

HYN49_06960

FMG:	HYN48_06610

FLO:	K1I41_04000

COC:

Coch_0704

CAPN:

CBG49_03905

CAPO:

HW278_05180

MARX:

INR76_03925 INR76_03930

SAHN:

JRG66_06860

FTE:	Fluta_0213

BBAU:

AEM51_03690

RMR:

Rmar_1136

RMG:	Rhom172_1666

SAF:	SULAZ_1208

PMX:	PERMA_1997

OCY:	OSSY52_03590(rfbE)

TYE:	THEYE_A0473 THEYE_A0474

NDE:	NIDE2875(rfbE)

NIF:

W02_12610

NWT:	NSPWAT_0368(rfbE)

SCHV:

BRCON_1881

MAE:

Maeo_0389

MBN:	Mboo_1767 Mboo_1768

HDL:	HALDL1_10980

SALI:

L593_04980

HBO:	Hbor_17010

HRM:	K6T25_01940

HRU:	Halru_1015

SACD:

HS1genome_1891

LOB:	NEF87_004249

PSYT:

DSAG12_01820

AGW:	QT03_C0001G0544

» show all

Reference

1 [PMID:5924649]

Authors

Matsuhashi S.

Title

Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. II. Reversible 2-epimerization of cytidine diphosphate paratose.

Journal

J Biol Chem 241:4275-82 (1966)

Reference

2 [PMID:7826006]

Authors

Liu HW, Thorson JS.

Title

Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria.

Journal

Annu Rev Microbiol 48:223-56 (1994)
DOI:10.1146/annurev.mi.48.100194.001255

Reference

3 [PMID:12642575]

Authors

Koropatkin NM, Liu HW, Holden HM

Title

High resolution x-ray structure of tyvelose epimerase from Salmonella typhi.

Journal

J Biol Chem 278:20874-81 (2003)
DOI:10.1074/jbc.M301948200

Sequence

[sty:STY2298]

Other DBs

ExplorEnz - The Enzyme Database:

5.1.3.10

IUBMB Enzyme Nomenclature:

5.1.3.10

ExPASy - ENZYME nomenclature database:

5.1.3.10

BRENDA, the Enzyme Database:

5.1.3.10

CAS:	37318-36-8

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