KEGG ENZYME: 5.1.3.26

ENZYME: 5.1.3.26

Entry

EC 5.1.3.26                 Enzyme

Name

N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase;
GlcNAc-P-P-Und epimerase;
GlcNAc-P-P-Und 4-epimerase;
gne (gene name)

Class

Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives

Sysname

N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase

Reaction(IUBMB)

N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R10554]

Reaction(KEGG)

R10554

Substrate

N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C01289]

Product

N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C20620]

Comment

The enzyme is involved in biosynthesis of the repeating tetrasaccharide unit of the O-antigen produced by some Gram-negative bacteria.

History

EC 5.1.3.26 created 2013

Orthology

K19997

GlcNAc-P-P-Und epimerase

Genes

ECE:

Z3206

ECS:	ECs_2847(gne)

ECF:	ECH74115_2976(gne)

ETW:	ECSP_2797(gne)

ELX:	CDCO157_2627

ESL:

O3K_09215

ESO:

O3O_16405

ESM:

O3M_09180

ECK:	EC55989_2298(gne)

ECG:	E2348C_2184(gne)

EOK:	G2583_2565(gne)

ELR:	ECO55CA74_12340

ECM:	EcSMS35_1020(gne)

ECR:	ECIAI1_2117(gne)

ECQ:	ECED1_2388(gne)

ECL:	EcolC_1599

EMA:	C1192_01700

SBG:

SBG_1917

SBC:	SbBS512_E1190(gne)

EPU:	QVH39_15235

ESA:

ESA_01176

CSK:

ES15_1414

CSJ:	CSK29544_02495

CDM:	AFK67_13190

CSI:	P262_02069

CMJ:	AFK66_006885

CFD:	CFNIH1_21450

CYO:	CD187_08940

CPOT:

FOB25_20225

HDE:	HDEF_0179(galE_1)

CNT:	JT31_20440

KCO:	BWI95_20085

KAS:	KATP_15980

KCY:	RIN60_08260

LEF:	LJPFL01_2722

IZH:	FEM41_21510

SCOL:

KFZ77_12735

YPY:

YPK_3179

YSI:	BF17_13495

YAK:	ACZ76_14280

YMA:	DA391_16660

SMAR:

SM39_2357(gne)

SMAC:

SMDB11_2153(gne)

SMW:	SMWW4_v1c28970

SPE:

Spro_2896

SRR:	SerAS9_2978

SRL:	SOD_c27230(gne)

SRY:	M621_14820

SPLY:

Q5A_015045(gnu)

SRS:	SerAS12_2979

SRA:	SerAS13_2980

SMAF:

D781_2683

SLQ:	M495_14930

SERF:

L085_14300

SERS:

SERRSCBI_13680

SRZ:	AXX16_2369

SERM:

CLM71_13860

SQU:	E4343_01560

SFJ:	SAMEA4384070_2913

SOF:	NCTC11214_03911(rmlB)

SSUR:

ATE40_011090

SURI:

J0X03_09460

SRHZ:

FO014_19800

SENP:

KHA73_14235

SNEM:

NLX84_14600

SNEV:

OI978_18015

SFO:	Z042_22575

GQU:	AWC35_22200

FSM:	CCS41_00970

PCV:	BCS7_06710

PPAR:

A8F97_03570

PPOO:

LW347_07190

PANP:

PSNIH2_05160

MINT:

C7M51_01871(gnu)

XHO:	A9255_14900

PRG:	RB151_044070(galE_3)

PHEI:

NCTC12003_03344

PRQ:	CYG50_16625

ANS:	ArsFIN_07600(gnu)

AET:	LDL57_00465

AAPC:

QG404_01590

EIC:	NT01EI_1309

ETC:	ETAC_05710

EHO:	A9798_10735

LPV:	HYN51_14485

LRI:	NCTC12151_01024(galE_1)

XBC:	ELE36_18940

XBA:	C7S18_03780

PCQ:	PcP3B5_48010(galE_1)

SLJ:	EGC82_14445

SPOL:

FH971_12795

PCAR:

PC2016_1873

MYA:	MORIYA_3321

MARQ:

MARGE09_P2537

LADL:

NCTC12735_01331(galE_3)

MPAD:

KEF85_04055 KEF85_11835

HHK:	HH1059_04080

OCM:	CBP12_12885

AQS:	DKK66_15875

COX:	E0W60_29830 E0W60_31350

PPAL:

AOC06_01775

SNIV:

SFSGTM_06310

REI:	IE4771_CH00813

RHT:

NT26_1041

SZO:	K8M09_21100

BRAD:

BF49_5660

BGQ:	X265_13735

BDG:	LPJ38_34180

BGK:	IC762_24900

BCOU:

IC761_27850

BXN:	I3J27_07740

BROS:

QUH67_25910

BRAZ:

LRP30_09590

XAU:

Xaut_3561

PHL:

KKY_3120

DSAL:

K1X15_10460

BVR:

BVIR_903

MLUT:

JET14_10150

BRN:	D1F64_22760

LABP:

FJ695_14230

CAK:

Caul_0135

CHQ:	AQ619_13015

ROT:	FIV09_18515

RCP:	RCAP_rcc01936(gne)

RBZ:	B9057_14975

PGV:	SL003B_3042(gne)

PBAE:

P8S53_02800

GAK:

X907_1850

PACO:

AACT_2575

DSF:	UWK_01606 UWK_02527

BSTO:

C0V70_07320

PCEL:

HUB94_27635

FPRA:

CG447_13080

FDU:	GXM22_10875

DOR:	Desor_5194

DMI:	Desmer_4163

EUZ:	DVS28_a1014

MRH:	MycrhN_1275

MAUU:

NCTC10437_05040(galE_3)

MMOR:

MMOR_59920(gnu)

MAIC:

MAIC_50230(gnu)

MPOF:

MPOR_19860

MHOL:

K3U96_21885

MPAE:

K0O64_02915

BCV:

Bcav_1168

PSEI:

GCE65_04465

HALT:

IM660_13960

RHAL:

LQF10_05475

RSUA:

LQF12_11990

SYNC:

CB0101_05320

PRC:

EW14_1482

FGI:	OP10G_3275

OBT:	OPIT5_05060

CAA:

Caka_1981

VBS:	EGM51_07950

MFF:	MFFC18_01490(galE_1)

PBAS:

SMSP2_01877

TAER:

GT409_12350

TDE:

TDE_1439

TBE:	Trebr_2227

TPK:	JO40_09965

TRM:	JO41_03080

TPHG:

FUT81_06790

TRZ:	GWP43_02880

TRP:	ABH09_02815

BPAA:

K7I13_00595

SLR:	L21SP2_3136

ADIN:

H7849_13860

FSU:	Fisuc_0995

FSC:

FSU_1441

GGR:	HKW67_12240

GBA:

J421_2491

BTH:

BT_2887

BTHO:

Btheta7330_02119(rmd)

BFR:

BF3647

BFS:	BF9343_1488 BF9343_2511 BF9343_3583

BFG:	BF638R_2586

BHL:	Bache_1980 Bache_2164 Bache_2248 Bache_2957

BXY:

BXY_37990

BOA:	Bovatus_00886 Bovatus_01171(galE_1) Bovatus_04914(galE_2)

BCEL:

BcellWH2_04981(rmd_3)

BCAC:

CGC64_12060

BIS:	DXK01_010855 DXK01_020645

BVU:	BVU_2955 BVU_4018

BSA:	Bacsa_1196

BDO:	EL88_07835

BDH:	GV66_15720 GV66_17420

PET:	PEIBARAKI_4444

PSAC:

PSM36_1384

PARY:

A4V02_05275

DDB:	E7747_01005

OSP:	Odosp_3011

PHER:

prwr041_16330

PRU:	PRU_0452 PRU_1755

ALQ:	C7Y71_007870

ADA:	A5CPEGH6_13570

DRC:	G0Q07_12735

MCOS:

GM418_23815

CPI:

Cpin_4748

CHIH:

GWR21_01140

FLS:	GLV81_01955

PSTY:

BFS30_06935

PEK:	FFJ24_019800

PSN:	Pedsa_3243

SPHN:

BV902_01955

SMIZ:

4412673_02365(galE_2)

SPHZ:

E3D81_03160

SPHE:

GFH32_08535

SDJ:	NCTC13534_03419 NCTC13534_03420(galE_1)

SBAM:

SCB77_13455

MUC:

MuYL_1759

MGK:	FSB76_19880

MMAB:

HQ865_06455

SBX:	CA265_19225

EVI:	Echvi_4391

EST:	DN752_19970

SPIR:

CWM47_29065

SPIB:

G8759_28100

FBT:	D770_16760

RCG:	N7E81_05700

ATK:	AUTU_44580(gnu)

FJG:	BB050_02180(galE_3)

FGL:	EM308_00720

FSN:	GS03_00613(fcl_1)

FNK:	E1750_13660

FOK:	KK2020170_07050

MART:

BTR34_14750

NDO:

DDD_3538

FOR:	FORMB_13010

MESQ:

C7H62_1061

MUT:	GVT53_17505

LUY:	QZH61_04260

EAO:

BD94_3329

EMN:	M876_13835

EEN:	BBD30_09955

ELB:	VO54_03300(galE_3)

EGO:	BBD34_06100

EGM:	AYC65_00590

ELZ:	FCS00_14520

ELIZ:

JCR23_14405

CIO:	CEQ15_13450

CHRZ:

CO230_02280

CCAU:

EG346_11910

EVA:	EIB75_15450

EBV:	F0358_04420

CPB:	Cphamn1_1916

CLI:

Clim_1879

PVI:

Cvib_0649

PAA:

Paes_1748

CACI:

CLOAM1566

TLE:

Tlet_0256

TYE:	THEYE_A0495

» show all

Reference

1 [PMID:19923219]

Authors

Rush JS, Alaimo C, Robbiani R, Wacker M, Waechter CJ

Title

A novel epimerase that converts GlcNAc-P-P-undecaprenol to GalNAc-P-P-undecaprenol in Escherichia coli O157.

Journal

J Biol Chem 285:1671-80 (2010)
DOI:10.1074/jbc.M109.061630

Sequence

[ece:Z3206]

Other DBs

ExplorEnz - The Enzyme Database:

5.1.3.26

IUBMB Enzyme Nomenclature:

5.1.3.26

ExPASy - ENZYME nomenclature database:

5.1.3.26

BRENDA, the Enzyme Database:

5.1.3.26

DBGET integrated database retrieval system