Entry
Name
dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase;
dTDP-deoxyglucose 3-epimerase;
dTDP-4-keto-6-deoxy-D-glucose 3-epimerase;
dTDP-4-keto-6-deoxyglucose 3-epimerase;
gerF (gene name);
tylJ (gene name);
chmJ (gene name);
mydH (gene name)
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname
dTDP-4-dehydro-6-deoxy-alpha-D-glucose 3-epimerase
Reaction(IUBMB)
dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-gulose [RN:
R06437 ]
Reaction(KEGG)
Substrate
dTDP-4-dehydro-6-deoxy-alpha-D-glucose [CPD:
C11907 ]
Product
dTDP-4-dehydro-6-deoxy-alpha-D-gulose [CPD:
C11926 ]
Comment
The enzyme is involved in the biosynthetic pathway of dTDP-6-deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.
History
EC 5.1.3.27 created 2013
Pathway
ec00523 Polyketide sugar unit biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K13312 dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
K19855 dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
Genes
Taxonomy
Reference
Authors
Sohng JK, Kim HJ, Nam DH, Lim DO, Han JM, Lee HJ, Yoo JC
Title
Cloning, expression, and biological function of a dTDP-deoxyglucose epimerase (gerF) gene from Streptomyces sp. GERI-155.
Journal
Sequence
Reference
Authors
Thuy TT, Liou K, Oh TJ, Kim DH, Nam DH, Yoo JC, Sohng JK
Title
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.
Journal
Sequence
Reference
Authors
Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM
Title
Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.27
ExPASy - ENZYME nomenclature database: 5.1.3.27