| Entry |
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| Name |
2-epi-5-epi-valiolone 7-phosphate 2-epimerase;
AcbO
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| Class |
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
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| Sysname |
2-epi-5-epi-valiolone-7-phosphate 2-epimerase
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| Reaction(IUBMB) |
2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate [RN: R11081]
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| Reaction(KEGG) |
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| Substrate |
2-epi-5-epi-valiolone 7-phosphate [CPD: C17692]
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| Product |
5-epi-valiolone 7-phosphate [CPD: C17693]
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| Comment |
The enzyme, isolated from the bacterium Actinoplanes sp. SE 50/110, is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.
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| History |
EC 5.1.3.35 created 2015
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| Pathway |
| ec00525 | Acarbose and validamycin biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K19974 | 2-epi-5-epi-valiolone 7-phosphate 2-epimerase |
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| Genes |
| AGAT: | RWV98_05130 RWV98_11890 RWV98_19295 |
| SLE: | sle_45850(sle_45850) |
| SCYA: | EJ357_02090 EJ357_14595 |
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| Reference |
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| Authors |
Zhang CS, Podeschwa M, Altenbach HJ, Piepersberg W, Wehmeier UF |
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| Title |
The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.1.3.35 |
| ExPASy - ENZYME nomenclature database: | 5.1.3.35 |
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