Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
[heparosan]-D-glucuronate 5-epimerase
Reaction(IUBMB)
[heparosan]-D-glucuronate = [acharan]-L-iduronate
Substrate
[heparosan]-D-glucuronate
Product
[acharan]-L-iduronate
Comment
The enzyme, characterized from the giant African snail Achatina fulica, participates in the biosynthetic pathway of acharan sulfate. Unlike EC 5.1.3.17, heparosan-N-sulfate-glucuronate 5-epimerase, it shows no activity with D-glucuronate residues in heparosan-N-sulfate.