KEGG ENZYME: 5.2.1.13

ENZYME: 5.2.1.13

Entry

EC 5.2.1.13                 Enzyme

Name

prolycopene isomerase;
CRTISO;
carotene cis-trans isomerase;
ZEBRA2 (gene name);
carotene isomerase;
carotenoid isomerase

Class

Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)

Sysname

7,9,7',9'-tetracis-lycopene cis-trans-isomerase

Reaction(IUBMB)

7,9,7',9'-tetracis-lycopene = all-trans-lycopene [RN:R07512]

Reaction(KEGG)

R07512

Substrate

7,9,7',9'-tetracis-lycopene [CPD:C15858]

Product

all-trans-lycopene [CPD:C05432]

Comment

Requires FADH2 [1]. The enzyme is involved in carotenoid biosynthesis.

History

EC 5.2.1.13 created 2011

Pathway

ec00906

Carotenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K09835

prolycopene isomerase

Genes

ATH:	AT1G06820(CRTISO)

ALY:

9328422

CRB:

17899122

CSAT:

104739241 104759100 104764727 104764772 104764782 104764820

EUS:	EUTSA_v10007141mg

BRP:

103843494

BNA:	106420156 125578640

BOE:

106307135

RSZ:

108805163

THJ:

104823508

CPAP:

110806395

CIT:

102577949

CIC:	CICLE_v10011230mg

PVY:	116118613 116132822

MINC:

123228115

TCC:

18598462

GRA:

105785422

GHI:	107922266 107940426

GAB:

108483253

HSYR:

120113745 120118580 120128904

DZI:

111311628

EGR:

104446658

GMX:	100798275 100811616

GSJ:	114372247 114393165

PVU:	PHAVU_007G265400g

VRA:

106772686

VAR:	108318783 108322550

VUN:

114192437

CCAJ:

109813368

APRC:

113871011

MTR:

25483622

TPRA:

123902400

CAM:

101494469

PSAT:

127091191

VVO:	131636089 131644729

LJA:	Lj0g3v0245759.1(Lj0g3v0245759.1) Lj0g3v0245759.2(Lj0g3v0245759.2)

ADU:

107476032

AIP:

107626297

AHF:	112728700 112757314

LANG:

109336113

PCIN:

129306266

QSA:	O6P43_005755

FVE:

101297853

RCN:

112191348

PPER:

18770912

PMUM:

103339574

PAVI:

110749117

PDUL:

117636179

MDM:

103454192

MSYL:

126600848

PXB:

103940205

ZJU:

107433597

MNT:

21389872

CSAV:

115701237

CSV:

101212850

CMO:

103486713

BHJ:

120090260

MCHA:

111019389

CMAX:

111498600

CMOS:

111445387

CPEP:

111800043

RCU:

8259794

JCU:

105635773

HBR:

110655834

MESC:

110620243

POP:	7479491 7488070

PEU:

105141575

PALZ:

118049770

JRE:

109011895

CILL:

122275663

CAVE:

132191346

QSU:

111991102

QLO:

115953799

TWL:

120012866

VVI:

100263250

VRI:

117920906

SLY:	101267857(CRTISO)

SPEN:

107002441

SOT:

102591604

SSTN:

125864929

SDUL:

129876041

CANN:

107854534

LBB:

132607253

NTA:	107791326 107832559(CRTISO)

NSY:

104243683

NTO:

104098775

NAU:

109244581

INI:

109181501

ITR:

116007558

SIND:

105161700

OEU:

111392821

EGT:

105956820

SSPL:

121747387 121787074

SMIL:

131020470

SHIS:

125211692

APAN:

127266248

HAN:

110873397

ECAD:

122608686

LSV:

111876520

CCAV:

112518493

DCR:

108219304

CSIN:

114260017

RVL:

131318537

AEW:

130789091

BVG:

104893199

SOE:

110798138

CQI:	110688863 110739864

ATRI:

130804473

MOF:

131161602

NNU:

104601462

MING:

122070777

TSS:

122643407

PSOM:

113309690 113322641

OSA:

4350758

DOSA:

Os11t0572700-00(Os11g0572700)

OBR:

102699732

OGL:

127754812

BDI:	100838443 100840652

ATS:

109736594

TDC:	119322939 119363390

TAES:

123109998 123180287 123189717

TUA:

125546725

LPER:

127295171

LRD:

124681557

SBI:

8071947

ZMA:	100281663 100281747

SITA:

101781301

SVS:

117833306

PVIR:

120644712 120685635

PHAI:

112903068

PDA:

103707328

EGU:

105042411

MUS:

103996172

ZOF:	122042680 122047185

DCT:

110108203

PEQ:

110020521

AOF:

109843839

MSIN:

131232828

NCOL:

116254200

ATR:

18421603

SMO:	SELMODRAFT_174745 SELMODRAFT_176387

PPP:	112273112 112275986

CME:	CYME_CMN268C

GSL:	Gasu_12840

ARHD:

VSH64_19360 VSH64_19400

SYN:

sll0033

SYZ:	MYO_128610

SYY:	SYNGTS_2835(sll0033)

SYT:	SYNGTI_2834(sll0033)

SYS:	SYNPCCN_2833(sll0033)

SYQ:	SYNPCCP_2833(sll0033)

SYJ:	D082_19610(crtH)

SYO:	C7I86_14805(crtH)

SYC:

syc0304_c

SYU:	M744_10405

SYF:	Synpcc7942_1246

SYD:	Syncc9605_1681

SYE:	Syncc9902_1423

SYG:	sync_1140(crtH)

SYR:	SynRCC307_1542(crtH)

SYX:	SynWH7803_1380(crtH)

CYA:	CYA_1857(crtH)

CYB:	CYB_1298(crtH)

SYNP:

Syn7502_00378

SYNK:

KR100_07270

SYNR:

KR49_03785

SYND:

KR52_07875

SYH:	Syncc8109_0960(crtH)

SYNW:

SynWH8103_01032(crtH)

SYNC:

CB0101_12360(crtH)

SYNY:

BM449_02040

DSL:	Dacsa_1002

SYW:	SYNW0901(crtH)

CGC:	Cyagr_0893

CYI:	CBM981_1144(crtH)

PMA:

Pro_0584

PMM:	PMM1115(crtH)

PMT:

PMT_1051

PMN:	PMN2A_0636

PMI:	PMT9312_1126

PMB:	A9601_12211(crtH)

PMC:	P9515_12061(crtH)

PMF:	P9303_10011(crtH)

PMG:	P9301_12221(crtH)

PMH:	P9215_12511(crtH)

PMJ:	P9211_05841(crtH)

PME:	NATL1_14681(crtH)

PRC:

EW14_1255

PRM:

EW15_1528

WNA:	KA717_06995(crtH)

CMP:	Cha6605_4541

CYN:	Cyan7425_2330

CEP:	Cri9333_4690

AMR:

AM1_1491

TSZ:	OOK60_02770(crtH)

LEN:	LEP3755_16360

LET:	O77CONTIG1_00409(crtI_1)

LBO:	LBWT_36280

LSC:	KIK02_22195(crtH)

LSK:	J5X98_27800(crtH)

HHG:	XM38_033160

PSEU:

Pse7367_3320

PSER:

ABRG53_3729

PGX:	OA858_18155(crtH)

THEU:

HPC62_08725(crtH)

TOG:	HNI00_18135(crtH)

TSIN:

OXH18_22935(crtH)

CHON:

NIES4102_17600

GDU:	P0S91_06830(crtH)

GEN:	GM3709_1160

GEE:	GM3708_1883

CAN:	Cyan10605_1127

CSN:	Cyast_0607

CYL:	AA637_01480(crtH)

SYP:	SYNPCC7002_A1892(crtH)

SYV:	AWQ23_09520

SYL:	AWQ21_09115

LEP:	Lepto7376_0524

SYNN:

NIES970_19150(crtH)

MAR:	MAE_12360(crtH)

MPK:

VL20_3318

MIQ:	B5D77_19865

MVZ:	myaer102_46370(crtH)

HAO:	PCC7418_3748

ENN:	FRE64_07135(crtH)

CYT:

cce_1534

CWA:	CwatDRAFT_4423

CYP:	PCC8801_1308

CYH:	Cyan8802_1336

CYC:	PCC7424_2254

CYJ:	Cyan7822_2172

TER:

Tery_2192

ARP:	NIES39_C05040(crtH)

PAGH:

NIES204_23180(crtH)

PPSU:

NO713_03656(CRTISO)

PRUN:

PCC7821_02797(CRTISO)

OXY:	HCG48_01570(crtH)

MVAG:

D0A34_00100(crtH)

LFS:	HFV01_18745(crtH)

OAC:	Oscil6304_3606

ONI:	Osc7112_5205

MPRO:

BJP34_14850

PHOR:

JWS08_18165(crtH)

PYH:	NEA10_19055(crtH)

MIC:	Mic7113_5497

GEI:	GEI7407_2988

ANA:

alr2064

NPU:	Npun_R4225

NOS:	Nos7107_0037

NOP:	Nos7524_5176

NON:	NOS3756_49190

NFL:	COO91_04720

NOE:	CLI64_01070(crtH)

NSH:

GXM_04909

NED:	HUN01_22360(crtH)

NPZ:	ACX27_00675

AVA:

Ava_3112

ANB:	ANA_C12463

ACY:	Anacy_1840

AWA:	AA650_14375

ANN:	EH233_12450(crtH)

CSG:	Cylst_2878

RSIN:

B6N60_01662

HBQ:	QI031_16460(crtH)

CALO:

Cal7507_1591

CALT:

Cal6303_5005

CALH:

IJ00_18455

CALN:

NIES2098_17920

RIV:	Riv7116_3610

FIS:	FIS3754_42210

NSP:	BMF81_03055(crtH)

NSPH:

BDGGKGIB_01213(crtI_1)

DHT:	NG743_00365(crtH)

STOQ:

K2F26_02165(crtH)

AEE:	IM676_07700(crtH)

TOQ:	HCG51_33720(crtH)

ALAX:

NIES50_41200

NCN:	BZZ01_22445

CTHE:

Chro_4528

PLP:	Ple7327_2552

SCS:	Sta7437_2143

STAN:

STA3757_46340

GLT:	GlitD10_2774(crtH)

GCY:	LQF76_08135(crtH)

CEO:

ETSB_1929

CER:	RGRSB_1068

CEEC:

P3F56_09915(crtH)

CTM:	Cabther_A0090

CVL:	J8C06_00450

CHLO:

J8C02_00455

CTE:

CT0649

CPC:

Cpar_0650

CCH:

Cag_1888

CPH:	Cpha266_0874

CPB:	Cphamn1_1701

CLI:

Clim_0766

PVI:

Cvib_1153

PLT:

Plut_0626

PPH:

Ppha_2151

PAA:

Paes_0760

PROC:

Ptc2401_01569(crtI)

PROS:

CHL67_07590

PROW:

OO006_04125

PROI:

OO005_04010

CTS:

Ctha_1262

» show all

Reference

1 [PMID:21209101]

Authors

Yu Q, Ghisla S, Hirschberg J, Mann V, Beyer P

Title

Plant carotene cis-trans isomerase CRTISO: a new member of the FAD(RED)-dependent flavoproteins catalyzing non-redox reactions.

Journal

J Biol Chem 286:8666-76 (2011)
DOI:10.1074/jbc.M110.208017

Reference

2 [PMID:20221689]

Authors

Li Q, Farre G, Naqvi S, Breitenbach J, Sanahuja G, Bai C, Sandmann G, Capell T, Christou P, Zhu C

Title

Cloning and functional characterization of the maize carotenoid isomerase and beta-carotene hydroxylase genes and their regulation during endosperm maturation.

Journal

Transgenic Res 19:1053-68 (2010)
DOI:10.1007/s11248-010-9381-x

Reference

3 [PMID:11884678]

Authors

Isaacson T, Ronen G, Zamir D, Hirschberg J

Title

Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of beta-carotene and xanthophylls in plants.

Journal

Plant Cell 14:333-42 (2002)
DOI:10.1105/tpc.010303

Sequence

[sly:101267857]

Reference

4 [PMID:21161331]

Authors

Chai C, Fang J, Liu Y, Tong H, Gong Y, Wang Y, Liu M, Wang Y, Qian Q, Cheng Z, Chu C

Title

ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice.

Journal

Plant Mol Biol 75:211-21 (2011)
DOI:10.1007/s11103-010-9719-z

Other DBs

ExplorEnz - The Enzyme Database:

5.2.1.13

IUBMB Enzyme Nomenclature:

5.2.1.13

ExPASy - ENZYME nomenclature database:

5.2.1.13

BRENDA, the Enzyme Database:

5.2.1.13

DBGET integrated database retrieval system