| Entry |
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| Name |
5-dehydro-4-deoxy-D-glucuronate isomerase;
4-deoxy-L-threo-5-hexulose uronate isomerase;
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase;
kduI (gene name)
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
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| Sysname |
5-dehydro-4-deoxy-D-glucuronate aldose-ketose-isomerase
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| Reaction(IUBMB) |
5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate [RN: R04383]
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| Reaction(KEGG) |
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| Substrate |
5-dehydro-4-deoxy-D-glucuronate [CPD: C04053]
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| Product |
3-deoxy-D-glycero-2,5-hexodiulosonate [CPD: C04349]
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| Comment |
The enzyme is involved in the degradation of polygalacturonate, a later stage in the degradation of pectin by many microorganisms.
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| History |
EC 5.3.1.17 created 1972, modified 2012
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| Pathway |
| ec00040 | Pentose and glucuronate interconversions |
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| Orthology |
| K01815 | 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase |
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| Genes |
| ECOO: | ECRM13514_3708(kduI) |
| ECOH: | ECRM13516_3571(kduI) |
| EDJ: | ECDH1ME8569_2750(kduI) |
| ECOI: | ECOPMV1_03133(kduI) |
| KIE: | NCTC12125_04812(kduI) |
| AHN: | NCTC12129_04539(kduI) |
| METY: | MRY16398_09680(kduI) |
| YPG: | YpAngola_A2642(kduI) |
| YPI: | YpsIP31758_1694(kduI) |
| SFJ: | SAMEA4384070_2182(kduI) |
| SOF: | NCTC11214_04717(kduI) |
| ECA: | ECA2400(kduI1) ECA4125(kduI2) |
| PATR: | EV46_11565 EV46_20530 |
| PATO: | GZ59_21570(kduI1) GZ59_41800(kduI2) |
| PWA: | Pecwa_2203 Pecwa_4107 |
| PPAR: | A8F97_07595 A8F97_20950 |
| PPUJ: | E2566_10215(kduI) E2566_19885(kduI) |
| PARI: | I2D83_01795(kduI) I2D83_10390(kduI) |
| PAQU: | DMB82_0018820(kduI) |
| PPOO: | LW347_09990(kduI) LW347_19910(kduI) |
| PVG: | CRN77_04630 CRN77_08465 |
| PRJ: | NCTC6933_00766(kduI) |
| ALIG: | NCTC10568_00273(kduI) |
| AVT: | NCTC3438_01897(kduI) |
| XFU: | XFF4834R_chr00850(kduI) |
| XOM: | XOO0167(XOO0167) XOO0168(XOO0168) |
| XPH: | XppCFBP6546_11085(kduI) |
| XHD: | LMG31886_01840(kduI) |
| LAQ: | GLA29479_2989(kduI1) |
| VNI: | VIBNI_B0398(kduI) VIBNI_B0647(kduI) |
| VPL: | SA104470976_03556(kduI) |
| CATE: | C2869_03885 C2869_05105 C2869_06410 C2869_22140 |
| SALH: | HMF8227_02584(kduI) |
| SAGA: | M5M_08090 M5M_10320 |
| GIL: | NHM04_01120(kduI) NHM04_13505(kduI) |
| MHYD: | GTQ55_16340(kduI) GTQ55_16395(kduI) |
| GAI: | IMCC3135_20265(kduI1) |
| AEL: | NCTC12917_01800(kduI) |
| PHT: | BLM14_15215 BLM14_24435 |
| SME: | SM_b21349 SMa0214(kduI) |
| SMK: | Sinme_4783 Sinme_5381 |
| SMQ: | SinmeB_3742 SinmeB_5518 |
| SMX: | SM11_pC1626(kduI) SM11_pD0673 |
| SMI: | BN406_04964(kduI1) BN406_05736(kduI2) |
| SMEG: | C770_GR4pC1318 C770_GR4pD0656 |
| SMEL: | SM2011_a0214(kduI) SM2011_b21349 |
| SMER: | DU99_24845 DU99_28795 |
| SFD: | USDA257_c13150(kduI1) USDA257_c17020(kduI2) |
| SAME: | SAMCFNEI73_pC1043(kduI) SAMCFNEI73_pC1189(kduI) |
| SINO: | SS05631_b56180 SS05631_b57600 |
| EAK: | EKH55_4273 EKH55_4817 |
| SKM: | PZL22_000180(kduI) PZL22_005761(kduI) |
| EAD: | OV14_b0195 OV14_b0360 |
| EAH: | FA04_30510 FA04_31220 |
| ECAA: | J3R84_34820(kduI) J3R84_35630(kduI) |
| ALF: | CFBP5473_22670(kduI) |
| AVV: | RvVAT039_11650(kduI) |
| AVF: | RvVAR031_31570(kduI) |
| ASAL: | CFBP5507_23245(kduI) |
| RPUS: | CFBP5875_14605(kduI) |
| ALEG: | CFBP4996_14985(kduI) |
| REL: | REMIM1_PD00421(kduI) |
| REP: | IE4803_PA00360(kduI) |
| REI: | IE4771_PC00373(kduI) |
| RHL: | LPU83_pLPU83d1431(kduI2) |
| RGA: | RGR602_PC01294(kduI) |
| RPHA: | AMC79_PB00323(kduI) |
| RSUL: | N2599_15700(kduI) N2599_25360(kduI) |
| RLW: | RlegWSM1455_31175(kduI) |
| RBW: | RLCC275e_30070(kduI) |
| NGL: | RG1141_CH04490 RG1141_PA03670 |
| NGG: | RG540_CH04130 RG540_PA03260 |
| NEN: | NCHU2750_31700(kduI) |
| NPM: | QEO92_20375(kduI) QEO92_21125(kduI) |
| RHT: | NT26_2979(kduI) NT26_3660(kduI) |
| RFV: | RFYW14_03061 RFYW14_03551 |
| MEY: | TM49_04560 TM49_07175 TM49_09015 TM49_12275 |
| MAAD: | AZF01_16340 AZF01_17080 |
| MLUT: | JET14_18540(kduI) JET14_19295(kduI) |
| PPHR: | APZ00_04370 APZ00_25370 |
| CAUF: | CSW63_15350 CSW63_16560 |
| AEX: | Astex_2132 Astex_3550 Astex_3592 |
| YAN: | AYJ57_18625 AYJ57_21210 |
| PARO: | CUV01_09150 CUV01_13965 |
| PSAP: | JHX88_07220(kduI) JHX88_12070(kduI) |
| PAEZ: | PAE61_01770(kduI) PAE61_08575(kduI) |
| LVS: | LOKVESSMR4R_01872(kduI) |
| SPHK: | SKP52_01825(kduI1) SKP52_19515(kduI2) |
| SPHX: | E5675_00675(kduI) E5675_14145(kduI) |
| SPHU: | SPPYR_3521(kduI) SPPYR_3767(kduI) |
| SSAN: | NX02_10245 NX02_15245 |
| SMY: | BJP26_13410 BJP26_16670 |
| SPHC: | CVN68_00400 CVN68_00435 |
| SPAP: | H3Z74_15850(kduI) H3Z74_18150(kduI) H3Z74_23370(kduI) |
| SBIN: | SBA_ch1_06470(kduI) |
| SCAB: | LZK98_09855(kduI) LZK98_16905(kduI) |
| SPHR: | BSY17_3174 BSY17_3777 |
| SYA: | A6768_14045 A6768_21690 |
| SPYG: | YGS_C2P0990 YGS_C2P1037 |
| SPHS: | ETR14_05345 ETR14_16560 |
| ALI: | AZOLI_p20544(kduI1) AZOLI_p40492(kduI2) |
| ATI: | AL072_16555 AL072_24875 |
| AZZ: | DEW08_18455 DEW08_25340 |
| NCB: | C0V82_16395 C0V82_24150 |
| PPOR: | JCM14722_25590(kduI) |
| BSON: | S101395_00570(kduI) |
| NDT: | L1999_06550(kduI) L1999_24050(kduI) L1999_27420(kduI) |
| BLEN: | NCTC4824_02952(kduI_1) |
| PPQ: | PPSQR21_048800(kduI) |
| PTHI: | NDS46_19050(kduI) NDS46_20070(kduI) |
| PNK: | AASFL403_00370(kduI) |
| SMEN: | SAMEA4412692_0269(kduI1) |
| LBK: | LVISKB_0125 LVISKB_0333 |
| LHB: | D1010_14970(kduI) D1010_15520(kduI) |
| EFA: | EF0425(kduI-1) EF2264(kduI-2) |
| EFC: | EFAU004_00255(kduI1) |
| EFAU: | EFAU085_00213(kduI1) |
| EFU: | HMPREF0351_10220(kduI) |
| EAV: | EH197_09370 EH197_12595 |
| ECEC: | NCTC12421_00387(kduI1) |
| CPF: | CPF_0395(kduI) CPF_0399(kduI) |
| CPR: | CPR_0391(kduI_1) CPR_0395(kduI_2) |
| CBEI: | LF65_00513 LF65_03073 |
| CCB: | Clocel_1514 Clocel_2263 |
| CBV: | U729_2509(kduI1) U729_2959(kduI1) |
| CFM: | BJL90_09325 BJL90_18375 |
| CGEL: | psyc5s11_28360(kduI2) |
| BPRO: | PMF13cell1_00848(kduI) |
| ACEL: | acsn021_08710(kduI) |
| ACHT: | bsdcttw_39420(kduI) |
| MFOR: | NQ534_01180(kduI) NQ534_02805(kduI) |
| CBAR: | PATL70BA_1172(kduI) PATL70BA_2600(kduI) |
| GFE: | Gferi_14645 Gferi_22855 |
| CLC: | Calla_0047 Calla_0377 |
| CDIA: | CaldiYA01_01220(kduI) |
| SCLA: | SCLARK_001255(kduI) |
| BROO: | brsh051_19950(kduI) |
| DVC: | Dvina_14510(kduI) Dvina_15625(kduI) |
| DMAT: | Dmats_14010(kduI) Dmats_15055(kduI) |
| OBG: | Verru16b_01543(kduI) |
| SLOM: | PXH66_13180(kduI) PXH66_13190(kduI) PXH66_20455(kduI) |
| FMO: | C4N19_04630 C4N19_12065 |
| BTHO: | Btheta7330_04117(kduI_1) Btheta7330_05072(kduI_2) |
| BOA: | Bovatus_03315(kduI_1) Bovatus_04355(kduI_2) |
| BCEL: | BcellWH2_02924(kduI) |
| BCAC: | CGC64_03770 CGC64_07045 |
| BCAE: | A4V03_02125 A4V03_18495 |
| BZG: | C4H11_03900 C4H11_08055 |
| BHF: | C3V43_00570 C3V43_08265 |
| BEG: | INE88_01819(kduI_1) INE88_02590(kduI_2) |
| BSTE: | K6V31_08030(kduI) K6V31_10565(kduI) |
| BFE: | K6V30_04765(kduI) K6V30_08940(kduI) |
| BFC: | BacF7301_05315(kduI) BacF7301_10170(kduI) |
| BFIN: | BFINE_11090(kduI1) BFINE_20320(kduI2) |
| BDO: | EL88_19285 EL88_24785 |
| BDH: | GV66_06170 GV66_09190 |
| COPR: | Cop2CBH44_06710(kduI1) |
| CFAS: | Cfast33896_03260(kduI) |
| PHER: | prwr041_17000(kduI2) |
| PCOU: | L6468_11905(kduI) L6468_13560(kduI) |
| POC: | NCTC13071_02250(kduI) |
| PBY: | L6471_04640(kduI) L6471_12445(kduI) |
| SHOI: | KUA50_011155(kduI) KUA50_015395(kduI) |
| SBAO: | L6469_07385(kduI) L6469_09365(kduI) |
| AIT: | AI2BBH_05640(kduI1) AI2BBH_10750(kduI2) |
| SDJ: | NCTC13534_05033(kduI) |
| STHA: | NCTC11429_01558(kduI) |
| SPIB: | G8759_09150(kduI) G8759_21280(kduI) |
| SENF: | GJR95_03880(kduI) GJR95_18725(kduI) |
| PSEZ: | HME7025_01206(kduI) |
| RSI: | Runsl_2245 Runsl_2294 |
| RUN: | DR864_19780 DR864_19960 |
| RUP: | DTQ70_21490 DTQ70_25355 |
| HYG: | AUC43_01950 AUC43_09450 |
| FGL: | EM308_09820 EM308_14520 |
| ZGA: | ZOBELLIA_189(kduI1) ZOBELLIA_255(kduI2) ZOBELLIA_3459(kduI3) ZOBELLIA_3807(kduI4) |
| ZLA: | Q5W13_00945(kduI) Q5W13_23295(kduI) |
| PRN: | BW723_03725 BW723_05870 |
| PUN: | NQP51_00785(kduI) NQP51_01235(kduI) |
| WFU: | AXE80_02530 AXE80_03620 |
| FOP: | FNB79_10055(kduI) FNB79_14930(kduI) |
| AALG: | AREALGSMS7_02521(kduI) |
| FEK: | C1H87_11125 C1H87_18185 |
| TAJ: | C1A40_02175 C1A40_13135 |
| AQB: | D1818_03345 D1818_12380 |
| AQD: | D1816_09420 D1816_12350 |
| CHRJ: | CHRYMOREF3P_1156(kduI) |
| KFA: | Q73A0000_08720(kduI) |
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| Reference |
1 |
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| Authors |
Preiss, J. |
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| Title |
4-Deoxy-L-threo-5-hexosulose uronic acid isomerase. |
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| Journal |
Methods Enzymol 9:602-604 (1966) |
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| Reference |
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| Authors |
Condemine G, Robert-Baudouy J |
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| Title |
Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Dunten P, Jaffe H, Aksamit RR |
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| Title |
Crystallization of 5-keto-4-deoxyuronate isomerase from Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Crowther RL, Georgiadis MM |
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| Title |
The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.1.17 |
| ExPASy - ENZYME nomenclature database: | 5.3.1.17 |
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