Entry
Name
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
BRITE hierarchy
Sysname
L-fucose aldose-ketose-isomerase
Reaction(IUBMB)
L-fucopyranose = L-fuculose [RN:
R03163 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires a divalent metal ion (the enzyme from the bacterium Escherichia coli prefers Mn2+). The enzyme binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism [3]. The enzyme from Escherichia coli can also convert D-arabinose to D-ribulose [1]. The enzyme from the thermophilic bacterium Caldicellulosiruptor saccharolyticus also converts D-altrose to D-psicose and L-galactose to L-tagatose [4].
History
EC 5.3.1.25 created 1999
Pathway
ec00051 Fructose and mannose metabolism
ec01120 Microbial metabolism in diverse environments
Orthology
K01818 L-fucose/D-arabinose isomerase
Genes
ECOO : ECRM13514_3666(fucI)
ECOH : ECRM13516_3530(fucI)
ELR : ECO55CA74_16475(fucI)
ECW : EcE24377A_3107(fucI)
ECOA : APECO78_17630(fucI)
EDJ : ECDH1ME8569_2712(fucI)
ECOI : ECOPMV1_03059(fucI)
SEM : STMDT12_C30280(fucI)
SETC : CFSAN001921_02190(fucI)
SEEN : SE451236_20975(fucI)
SENH : CFSAN002069_17340(fucI)
SEEH : SEEH1578_00940(fucI)
SENJ : CFSAN001992_18685(fucI)
SEEC : CFSAN002050_21235(fucI)
SEEB : SEEB0189_005245(fucI)
SENC : SEET0819_21745(fucI)
RTG : NCTC13098_01323(fucI_1)
KIE : NCTC12125_04897(fucI)
PSHI : SAMEA2665130_0773(fucI)
HIC : NTHIC486_00795(fucI)
HAEG : NCTC8502_00350(fucI)
PDAG : 4362423_01534(fucI)
ALIG : NCTC10568_02052(fucI)
AVT : NCTC3438_00412(fucI)
RPNE : NCTC8284_00976(fucI_1)
PAET : NCTC13378_02020(fucI)
SDP : NCTC12225_00392(fucI_2)
GYM : GYMC10_3790 GYMC10_3924
PIB : BBD41_01795 BBD41_26020
PLUT : EI981_07160 EI981_11130
PBK : Back11_04290(fucI_1) Back11_44000(fucI_2)
PAMY : P9222_19790 P9222_21145
PMAE : LMZ02_12575 LMZ02_27705
PKP : SK3146_02882(fucI_1) SK3146_04427(fucI_2) SK3146_05590(fucI_3)
COH : EAV92_10205 EAV92_13420
COHN : KCTCHS21_24140(fucI)
SNV : SPNINV200_19690(fucI)
SNC : HMPREF0837_10161(fucI)
SPNG : HMPREF1038_02168(fucI)
SPNE : SPN034156_09830(fucI)
SPNU : SPN034183_19060(fucI)
SPNM : SPN994038_18950(fucI)
SPNO : SPN994039_18960(fucI)
PETR : QKW49_19800 QKW49_22585
BPRO : PMF13cell1_02382(fucI)
BLAR : LC508_11675 LC508_20810
BLUI : Blut17040_26750(fucI)
CSCI : HDCHBGLK_01967(fucI)
CHYL : CE91St63_31890 CE91St63_31980(fucI)
ACEL : acsn021_29440(fucI)
ACHT : bsdcttw_01450(fucI)
CBOL : CGC65_09370 CGC65_12640
QDO : H9Q78_12545 H9Q78_12595
HALS : D7D81_01100 D7D81_03900
IFN : GM661_01500 GM661_17170
CDIA : CaldiYA01_05230(fucI)
PPC : HMPREF9154_0923(fucI)
ANE : ATCC27039_06250(fucI)
ASLA : NCTC11923_01262(fucI)
AVC : NCTC10951_00406(fucI)
SBAE : DSM104329_00431(fucI)
ABAO : BEQ56_03095 BEQ56_06395
ABIW : Abiwalacus_19630(fucI)
TAER : GT409_08110 GT409_08215
BTHO : Btheta7330_01956(fucI)
BCEL : BcellWH2_03053(fucI_1) BcellWH2_05278(fucI_2)
BIS : DXK01_004665 DXK01_015470(fucI)
BFC : BacF7301_20945(fucI)
PET : PEIBARAKI_4033 PEIBARAKI_4378
PSAC : PSM36_0006(fucI1) PSM36_3369(fucI3)
COPR : Cop2CBH44_14930(fucI_1) Cop2CBH44_30610(fucI_2)
SMIZ : 4412673_01335(fucI)
SDJ : NCTC13534_02089(fucI)
STHA : NCTC11429_00383(fucI)
AALG : AREALGSMS7_01724(fucI)
ALAM : RT761_00408(fucI_1) RT761_00630(fucI_2) RT761_02420(araA)
» show all
Taxonomy
Reference
Authors
GREEN M, COHEN SS.
Title
Enzymatic conversion of L-fucose to L-fuculose.
Journal
J Biol Chem 219:557-68 (1956)
Sequence
Reference
Authors
Lu Z, Lin EC
Title
The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation.
Journal
Sequence
Reference
Authors
Seemann JE, Schulz GE
Title
Structure and mechanism of L-fucose isomerase from Escherichia coli.
Journal
Sequence
Reference
Authors
Ju YH, Oh DK
Title
Characterization of a recombinant L-fucose isomerase from Caldicellulosiruptor saccharolyticus that isomerizes L-fucose, D-arabinose, D-altrose, and L-galactose.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 5.3.1.25
ExPASy - ENZYME nomenclature database: 5.3.1.25