| Entry |
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| Name |
ribose-1,5-bisphosphate isomerase;
R15P isomerase;
ribulose 1,5-bisphosphate synthase;
RuBP synthase
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
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| Sysname |
alpha-D-ribose 1,5-bisphosphate aldose-ketose-isomerase
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| Reaction(IUBMB) |
alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate [RN: R10555]
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| Reaction(KEGG) |
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| Substrate |
alpha-D-ribose 1,5-bisphosphate [CPD: C01151]
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| Product |
D-ribulose 1,5-bisphosphate [CPD: C01182]
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| Comment |
This archaeal enzyme is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The enzyme is activated by cAMP [2].
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| History |
EC 5.3.1.29 created 2013
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| Pathway |
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| Orthology |
| K18237 | ribose 1,5-bisphosphate isomerase |
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| Genes |
| ACOL: | K5I23_08745 K5I23_13025 |
| ERB: | A4V01_03310 A4V01_03935 |
| CIU: | G4D55_01500 G4D55_02115 |
| HALH: | HTSR_1620 HTSR_1864 |
| HHSR: | HSR6_1688 HSR6_1933 |
| HSU: | HLASF_0414 HLASF_1916 |
| HSF: | HLASA_0413 HLASA_1902 |
| HALR: | EFA46_000470 EFA46_013245 |
| HHI: | HAH_1030(eif2BD1) HAH_2467(eif2BD2) |
| HHN: | HISP_05295 HISP_12560 |
| HAB: | SG26_04865 SG26_12965 |
| NMO: | Nmlp_1786(tif2Bd) Nmlp_3000(tif2Ba) |
| NHO: | HWV23_07735 HWV23_14670 |
| NSAL: | HWV07_10115 HWV07_18135 |
| HALI: | BV210_01305 BV210_10815 |
| HSN: | DV733_06015 DV733_10460 |
| HSAL: | JMJ58_06260 JMJ58_10535 |
| HXA: | Halxa_1680 Halxa_3413 |
| NPE: | Natpe_0259 Natpe_3491 |
| NPL: | FGF80_09535 FGF80_15055 |
| NGE: | Natgr_1133 Natgr_2288 |
| NOU: | Natoc_0402 Natoc_2480 |
| HLC: | CHINAEXTREME02065 CHINAEXTREME06955 |
| NAJ: | B1756_00190 B1756_04360 |
| NAG: | AArcMg_0285 AArcMg_3194 |
| NAS: | GCU68_03210 GCU68_07770 |
| HDA: | BB347_11090 BB347_11970 |
| MER: | MMINT_06510 MMINT_17710 |
| SHC: | Shell_1087 Shell_1088 |
| PDL: | Pyrde_1813 Pyrde_1814 |
| PABI: | PABY_18100 PABY_18110 |
| PARE: | PYJP_01020 PYJP_01030 |
| THB: | N186_02935 N186_02940 |
| TCB: | TCARB_1655 TCARB_1656 |
| THF: | MA03_08045 MA03_08050 |
| THEL: | IG193_05630 IG193_05635 |
| CCAI: | NAS2_1493 NAS2_1494 |
| BARC: | AOA65_0862 AOA65_0864 |
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| Reference |
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| Authors |
Sato T, Atomi H, Imanaka T |
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| Title |
Archaeal type III RuBisCOs function in a pathway for AMP metabolism. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Aono R, Sato T, Yano A, Yoshida S, Nishitani Y, Miki K, Imanaka T, Atomi H |
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| Title |
Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Nakamura A, Fujihashi M, Aono R, Sato T, Nishiba Y, Yoshida S, Yano A, Atomi H, Imanaka T, Miki K |
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| Title |
Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.1.29 |
| ExPASy - ENZYME nomenclature database: | 5.3.1.29 |
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