Entry
Name
(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase;
lsrG (gene name);
phospho-AI-2 isomerase;
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione aldose-ketose-isomerase;
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione aldose-ketose-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
BRITE hierarchy
Sysname
(2S)-2-hydroxy-3,4-dioxopentyl phosphate aldose-ketose-isomerase
Reaction(IUBMB)
(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate [RN:
R10939 ]
Reaction(KEGG)
Substrate
(2S)-2-hydroxy-3,4-dioxopentyl phosphate [CPD:
C20959 ]
Product
3-hydroxy-2,4-dioxopentyl phosphate [CPD:
C20960 ]
Comment
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.
History
EC 5.3.1.32 created 2015
Orthology
K11530 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
Genes
ECOO : ECRM13514_1873(lsrG)
ECOH : ECRM13516_1883(lsrG)
EDJ : ECDH1ME8569_1461(lsrG)
SEM : STMDT12_C42260(lsrG)
REE : electrica_00593(lsrG)
RTG : NCTC13098_00816(lsrG)
CLAP : NCTC11466_04015(lsrG)
AHN : NCTC12129_00641(lsrG)
METY : MRY16398_06820(lsrG)
SMW : SMWW4_v1c13620(lsrG)
SFJ : SAMEA4384070_1444(lsrG)
SOF : NCTC11214_05536(lsrG)
HIC : NTHIC486_00207(lsrG)
AVT : NCTC3438_00373(lsrG)
PAET : NCTC13378_00055(lsrG)
PSEP : C4K39_4985 C4K39_4987
MISZ : MishRS11D_34870(lsrG)
TNI : TVNIR_3137(lsrG_[H])
THIC : TspCOW1_02870(lsrG)
CDIZ : CEDIAZO_00815(lsrG)
CNC : CNE_BB1p10100 CNE_BB2p00640 CNE_BB2p00650
URU : DSM104443_01142(lsrG)
LABR : CHH27_00085 CHH27_27480
SULI : C1J05_01770 C1J05_17180
SLIA : HA039_02170 HA039_07615
ACIJ : JS278_00875(lsrG_2)
» show all
Taxonomy
Reference
Authors
Xavier KB, Miller ST, Lu W, Kim JH, Rabinowitz J, Pelczer I, Semmelhack MF, Bassler BL
Title
Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.
Journal
Sequence
Reference
Authors
Marques JC, Lamosa P, Russell C, Ventura R, Maycock C, Semmelhack MF, Miller ST, Xavier KB
Title
Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.3.1.32
ExPASy - ENZYME nomenclature database: 5.3.1.32