| Entry |
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| Name |
2-dehydrotetronate isomerase;
otnI (gene name)
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
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| Sysname |
2-dehydrotetronate isomerase
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| Reaction(IUBMB) |
(1) 2-dehydro-L-erythronate = 3-dehydro-L-erythronate [RN: R11721];
(2) 2-dehydro-D-erythronate = 3-dehydro-D-erythronate [RN: R11722]
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| Reaction(KEGG) |
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| Substrate |
2-dehydro-L-erythronate [CPD: C21618];
2-dehydro-D-erythronate [CPD: C21617]
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| Product |
3-dehydro-L-erythronate [CPD: C21612];
3-dehydro-D-erythronate [CPD: C03064]
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| Comment |
The enzyme, characterized from bacteria, is involved in D-erythronate and L-threonate catabolism.
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| History |
EC 5.3.1.35 created 2017
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| Orthology |
| K22131 | 2-dehydrotetronate isomerase |
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| Genes |
| EDJ: | ECDH1ME8569_2649(ygbM) |
| ECOI: | ECOPMV1_02997(ygbM) |
| KPZ: | KPNIH27_12255 KPNIH27_26655 |
| SFJ: | SAMEA4384070_1538(ygbM) |
| SOF: | NCTC11214_05431(ygbM_2) |
| GQU: | AWC35_02250 AWC35_04605 |
| PHEI: | NCTC12003_00572(ygbM) |
| PRJ: | NCTC6933_00626(ygbM) |
| LRI: | NCTC12151_03003(ygbM) |
| AVT: | NCTC3438_00336(ygbM) |
| RPNE: | NCTC8284_00712(ygbM) |
| PAET: | NCTC13378_01828(ygbM) |
| PCH: | EY04_12640 EY04_18165 |
| PPSL: | BJP27_05895 BJP27_07940 |
| GAI: | IMCC3135_12970(ygbM) |
| HAXI: | HAALTHF_14870n(hyi) |
| ZDF: | AN401_07765 AN401_17900 |
| CHJ: | NCTC10426_00302(ygbM) |
| BPM: | BURPS1710b_A0442(hyi) |
| BPL: | BURPS1106A_A1924(hyi) |
| BGD: | bgla_1g15030 bgla_2g06370 |
| BUM: | AXG89_18565 AXG89_18915 |
| BUI: | AX768_28345 AX768_28690 |
| PARA: | BTO02_14855 BTO02_24255 |
| PEW: | KZJ38_07810 KZJ38_26010 |
| PKF: | RW095_04025 RW095_08610 RW095_17935 |
| PLG: | NCTC10937_05026(hyi) |
| LMIR: | NCTC12852_02442(ygbM) |
| CABA: | SBC2_17840(otnI_1) SBC2_68750(otnI_2) |
| BTRM: | SAMEA390648703825(hyi) |
| AXY: | AXYL_05981(hyi1) AXYL_05996(hyi2) |
| AXO: | NH44784_026161 NH44784_026251 |
| AXN: | AX27061_5666 AX27061_5675 |
| AXX: | ERS451415_05689(hyi) ERS451415_05698(ygbM) |
| ADT: | APT56_26190 APT56_26235 |
| AIS: | BUW96_23315 BUW96_23435 |
| ASW: | CVS48_08800 CVS48_08975 |
| ACHR: | C2U31_02455 C2U31_02540 |
| ACHB: | DVB37_25835 DVB37_25930 |
| ADY: | HLG70_23700 HLG70_23745 |
| APES: | FOC84_15455 FOC84_15530 |
| AAEG: | RA224_29755 RA224_29830 |
| ACK: | C380_05275 C380_23800 |
| AMON: | H9L24_15945 H9L24_19525 |
| CAQT: | KAQ61_11525 KAQ61_16425 |
| RBN: | RBXJA2T_07758 RBXJA2T_14136 |
| ATER: | MW290_12295 MW290_23595 |
| AZA: | AZKH_0720 AZKH_p0079 |
| NKI: | KW403_07325 KW403_07570 |
| RHL: | LPU83_pLPU83c0747 LPU83_pLPU83d1674 |
| RGA: | RGR602_CH03644 RGR602_PC01503 |
| RROS: | D4A92_07685 D4A92_23260 |
| RBW: | RLCC275e_26005 RLCC275e_27575 |
| BSW: | IY71_09835 IY71_11815 |
| BSG: | IY72_09575 IY72_11355 |
| VGO: | GJW-30_1_03230(ygbM) |
| RLI: | RLO149_c006580 RLO149_c042460 |
| RPON: | G3256_00905 G3256_03975 |
| PHP: | PhaeoP97_00102(ygbM) |
| PPIC: | PhaeoP14_00068(ygbM) |
| OAT: | OAN307_c00570 OAN307_c20280 |
| SINL: | DSM14862_03144(otnI) |
| SUAL: | KDD17_00645 KDD17_15930 |
| SPSE: | SULPSESMR1_01369(hyi) SULPSESMR1_03310(ygbM) |
| TOM: | BWR18_10310 BWR18_17790 |
| RMM: | ROSMUCSMR3_03168(ygbM) |
| AHT: | ANTHELSMS3_04461(ygbM) |
| LALG: | LentiSH36_00046(ygbM) |
| PAMI: | JCM7686_1062 JCM7686_pAMI4p301 |
| PYE: | A6J80_10130 A6J80_12785 |
| PARO: | CUV01_05845 CUV01_17140 |
| PMUT: | DPM13_08335 DPM13_11245 |
| PARR: | EOJ32_10140 EOJ32_15815 |
| PKD: | F8A10_07910 F8A10_18075 |
| PPAN: | ESD82_06280 ESD82_20395 |
| PMAU: | CP157_00440(otnI_1) CP157_01649(hyi_1) |
| PMEH: | JWJ88_03255 JWJ88_13050 |
| PSEW: | JHW44_07505 JHW44_18860 |
| PFIS: | JHX87_02475 JHX87_07215 |
| PFEO: | E3U26_15030 E3U26_19410 |
| THW: | BMG03_05480 BMG03_06745 |
| TEC: | AKL02_004315 AKL02_005615 AKL02_020900 |
| PPHT: | GA004_05275 GA004_08715 |
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| Reference |
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| Authors |
Zhang X, Carter MS, Vetting MW, San Francisco B, Zhao S, Al-Obaidi NF, Solbiati JO, Thiaville JJ, de Crecy-Lagard V, Jacobson MP, Almo SC, Gerlt JA |
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| Title |
Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.1.35 |
| ExPASy - ENZYME nomenclature database: | 5.3.1.35 |
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