KEGG   ENZYME: 5.3.3.24
Entry
EC 5.3.3.24                 Enzyme                                 
Name
neopinone isomerase;
NISO (gene name)
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
Sysname
neopinone Delta8-Delta7-isomerase
Reaction(IUBMB)
neopinone = codeinone [RN:R05125]
Reaction(KEGG)
R05125
Substrate
neopinone [CPD:C06172]
Product
codeinone [CPD:C06171]
Comment
The enzyme, characterized from the opium poppy (Papaver somniferum), participates in the biosynthesis of morphine. It also catalyses the isomerization of neomorphinone and morphinone.
History
EC 5.3.3.24 created 2022
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01828  neopinone isomerase
Genes
PSOM: 113320582 113323967 113325420
Reference
1  [PMID:30886433]
  Authors
Dastmalchi M, Chen X, Hagel JM, Chang L, Chen R, Ramasamy S, Yeaman S, Facchini PJ.
  Title
Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy.
  Journal
Nat Chem Biol 15:384-390 (2019)
DOI:10.1038/s41589-019-0247-0
  Sequence
[psom:113325420 113320582]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.24
IUBMB Enzyme Nomenclature: 5.3.3.24
ExPASy - ENZYME nomenclature database: 5.3.3.24
BRENDA, the Enzyme Database: 5.3.3.24

  All links  
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (3)   
All databases (14)   

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