KEGG ENZYME: 5.4.2.4

ENZYME: 5.4.2.4

Entry

EC 5.4.2.4                  Enzyme

Name

bisphosphoglycerate mutase;
diphosphoglycerate mutase;
glycerate phosphomutase;
bisphosphoglycerate synthase;
bisphosphoglyceromutase;
biphosphoglycerate synthase;
diphosphoglyceric mutase;
2,3-diphosphoglycerate mutase;
phosphoglyceromutase;
2,3-diphosphoglycerate synthase;
DPGM;
2,3-bisphosphoglycerate mutase;
BPGM;
diphosphoglyceromutase;
2,3-diphosphoglyceromutase

Class

Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)

Sysname

3-phospho-D-glycerate 1,2-phosphomutase

Reaction(IUBMB)

3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate [RN:R01662]

Reaction(KEGG)

R01662

Substrate

3-phospho-D-glyceroyl phosphate [CPD:C00236]

Product

2,3-bisphospho-D-glycerate [CPD:C01159]

Comment

In the direction shown, this enzyme is phosphorylated by 3-phosphoglyceroyl phosphate, to give phosphoenzyme and 3-phosphoglycerate. The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. This enzyme also catalyses, slowly, the reaction of EC 5.4.2.11 [phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)] and EC 5.4.2.12 [phosphoglycerate mutase (2,3-diphosphoglycerate-independent)].

History

EC 5.4.2.4 created 1961 as EC 2.7.5.4, transferred 1984 to EC 5.4.2.4

Pathway

ec00010

Glycolysis / Gluconeogenesis

ec01100

Metabolic pathways

Orthology

K01837

bisphosphoglycerate/phosphoglycerate mutase

Genes

HSA:

669(BPGM)

PTR:	463746(BPGM)

PPS:	100967755(BPGM)

GGO:	101148078(BPGM)

PON:	100445966(BPGM)

NLE:	100586238(BPGM)

HMH:	116814381(BPGM)

MCC:	706741(BPGM)

MCF:	101925598(BPGM)

MTHB:

126949690

MNI:	105471341(BPGM)

CSAB:

103226934(BPGM)

CATY:

105589610(BPGM)

PANU:

101022185(BPGM)

TGE:	112620672(BPGM)

MLEU:

105533670(BPGM)

RRO:	104655279(BPGM) 104657786

RBB:	108522539(BPGM)

TFN:	117073599(BPGM)

PTEH:

111524783(BPGM)

CANG:

105511140(BPGM)

CJC:	100386672(BPGM) 128928554

SBQ:	101031409(BPGM)

CIMI:

108307282(BPGM)

CSYR:

103275724(BPGM)

MMUR:

105860194(BPGM)

LCAT:

123647165(BPGM)

PCOQ:

105815458(BPGM)

OGA:	100956918(BPGM)

MMU:	12183(Bpgm)

MCAL:

110296243(Bpgm)

MPAH:

110316482(Bpgm)

RNO:	296973(Bpgm)

MCOC:

116098708(Bpgm)

ANU:	117720855(Bpgm)

MUN:	110561663(Bpgm)

CGE:	100757548(Bpgm)

MAUA:

101840847(Bpgm)

PROB:

127215423(Bpgm)

PLEU:

114691032(Bpgm)

MORG:

121463368(Bpgm)

MFOT:

126505296

AAMP:

119807579(Bpgm)

NGI:	103726061(Bpgm)

HGL:	101706859(Bpgm)

CPOC:

100722842(Bpgm)

CCAN:

109688796

DORD:

105989600(Bpgm)

DSP:	122099556(Bpgm) 122125320

PLOP:

125347168(Bpgm)

NCAR:

124986309 124990814

MMMA:

107149035(Bpgm)

OCU:	100009096(BPGM)

OPI:	101521357(BPGM)

TUP:	102496494(BPGM)

GVR:	103601037 103604804

CFA:	482704(BPGM)

CLUD:

112670467(BPGM)

VVP:	112908884(BPGM)

VLG:	121489532(BPGM)

NPO:	129516217(BPGM)

AML:	100479620(BPGM)

UMR:	103678255(BPGM)

UAH:	113264369(BPGM)

UAR:	123788931(BPGM)

ELK:

111151975

LLV:

125081060

MPUF:

101674272(BPGM)

MNP:	132015686(BPGM)

MLK:	131829792(BPGM)

NVS:	122905090(BPGM)

ORO:	101365932(BPGM)

EJU:	114211742(BPGM)

ZCA:	113911925(BPGM)

MLX:	118021113(BPGM)

NSU:	110582871(BPGM)

LWW:	102729597(BPGM)

FCA:	101095644(BPGM)

PYU:	121028302(BPGM) 121031877

PCOO:

112866662(BPGM)

PBG:	122488305(BPGM)

PVIV:

125160935(BPGM)

LRUF:

124524429

PTG:	102952979(BPGM)

PPAD:

109269034(BPGM)

PUC:

125930157

AJU:

106975708

HHV:	120238873(BPGM)

BTA:	112447087 533785(BPGM)

BOM:	102270409 102275256 102275503 102285424

BIU:	109557654(BPGM)

BBUB:

102402470(BPGM)

BBIS:

104982297(BPGM)

CHX:	102187916(BPGM)

OAS:	101121089(BPGM)

BTAX:

128046411(BPGM)

ODA:	120878223(BPGM)

CCAD:

122438665(BPGM)

MBEZ:

129552666(BPGM)

SSC:	106506774(BPGM)

CFR:	102514048(BPGM)

CBAI:

105063063(BPGM)

CDK:	105085404(BPGM)

VPC:	102540862(BPGM)

BACU:

103009787(BPGM) 103015640

BMUS:

118891256 118901329(BPGM)

LVE:	103089210(BPGM)

OOR:	101286738 101287641(BPGM)

DLE:	111178164(BPGM) 111178314

PCAD:

102985972(BPGM)

PSIU:

116759523(BPGM) 116764955

NASI:

112392791 112394975(BPGM)

ECB:	100065115(BPGM)

EPZ:	103551316(BPGM)

EAI:	106830008(BPGM)

MYB:	102254057(BPGM)

MYD:	102772643(BPGM)

MMYO:

118666381(BPGM) 118676662

MLF:	102437274(BPGM)

PKL:	118713079(BPGM)

EFUS:

103294121(BPGM)

MNA:	107544342(BPGM)

DRO:	112299894(BPGM)

SHON:

118989129(BPGM)

AJM:	119064246(BPGM)

PDIC:

114507744(BPGM)

PHAS:

123829765(BPGM)

MMF:	118619861(BPGM)

PPAM:

129062906(BPGM)

HAI:	109389371(BPGM)

RFQ:	117018353(BPGM)

PALE:

102886645(BPGM)

PGIG:

120600999(BPGM)

PVP:	105291639(BPGM)

RAY:	107510540(BPGM)

MJV:	108396501(BPGM)

TOD:	119247218(BPGM)

SARA:

101557521(BPGM)

LAV:	100673907(BPGM)

TMU:

101360256

ETF:	101648579(BPGM)

DNM:	101418854(BPGM)

MDO:	100021814(BPGM)

GAS:	123249258(BPGM)

SHR:	100920227(BPGM)

AFZ:

127539411

PCW:	110219158(BPGM)

OAA:	100075920(BPGM)

GGA:	418172(BPGM)

PCOC:

116226884(BPGM)

MGP:	100546129(BPGM)

CJO:	107314945(BPGM)

TPAI:

128073371(BPGM)

LMUT:

125703131(BPGM)

NMEL:

110395716(BPGM)

APLA:

101803151(BPGM)

ACYG:

106030917(BPGM)

CATA:

118250121(BPGM)

AFUL:

116501828(BPGM)

TGU:	100221163(BPGM)

LSR:	110482586(BPGM)

SCAN:

103820477(BPGM)

PMOA:

120501586(BPGM)

OTC:	121332759(BPGM)

PRUF:

121362704(BPGM)

GFR:	102033451(BPGM)

FAB:	101817641(BPGM)

OMA:	130263199(BPGM)

PHI:	102108959(BPGM)

PMAJ:

107204390(BPGM)

CCAE:

111928156(BPGM)

CCW:	104692259(BPGM)

CBRC:

103624705(BPGM)

ETL:	114066474(BPGM)

ZAB:	102069397(BPGM)

ACHL:

103809151(BPGM)

SVG:	106849441(BPGM)

MMEA:

130588970(BPGM)

HRT:	120751396(BPGM)

FPG:	101915204(BPGM)

FCH:	102046661(BPGM)

CLV:	102089457(BPGM)

EGZ:	104134376(BPGM)

NNI:	104017943(BPGM)

PCRI:

104026196(BPGM)

PLET:

104624741(BPGM)

EHS:	104516903(BPGM)

PCAO:

104045004(BPGM)

ACUN:

113491488(BPGM)

TALA:

104361469(BPGM)

PADL:

103924352(BPGM)

AFOR:

103898662(BPGM)

ACHC:

115352328(BPGM)

HALD:

104314996(BPGM)

HLE:	104830915(BPGM)

AGEN:

126048074

GCL:

127029695

CCRI:

104162724(BPGM)

CSTI:

104551983(BPGM)

CMAC:

104480596(BPGM)

MUI:	104535330(BPGM)

BREG:

104639226(BPGM)

FGA:	104072180(BPGM)

GSTE:

104252617(BPGM)

LDI:	104341706(BPGM)

MNB:	103768831(BPGM)

OHA:	104337122(BPGM)

NNT:	104404033(BPGM)

SHAB:

115605757(BPGM)

DPUB:

104304682(BPGM)

PGUU:

104469551(BPGM)

ACAR:

104529043(BPGM)

CPEA:

104384749 104393436(BPGM)

AVIT:

104272414(BPGM)

CVF:	104281617(BPGM)

RTD:	128904048(BPGM)

CUCA:

104064597(BPGM)

TEO:	104371170(BPGM)

BRHI:

104489910(BPGM)

AAM:	106488955(BPGM)

AROW:

112968285(BPGM)

NPD:	112945515(BPGM)

TGT:	104573508(BPGM)

DNE:	112993366(BPGM)

SCAM:

104147258(BPGM)

ASN:	102373803(BPGM)

AMJ:	102568684(BPGM)

CPOO:

109316438(BPGM)

GGN:	109296253(BPGM)

PSS:	102447629(BPGM)

CMY:	102946921(BPGM)

CCAY:

125625700(BPGM)

DCC:	119863402(BPGM)

CPIC:

101941911(BPGM)

TST:	117882902(BPGM)

CABI:

116835612(BPGM)

MRV:	120380589(BPGM)

ACS:	100564984(bpgm)

ASAO:

132775754(BPGM)

PVT:	110088825(BPGM)

SUND:

121930490(BPGM)

PBI:	103062795(BPGM)

PMUR:

107294354(BPGM)

CTIG:

120319426(BPGM)

TSR:	106545025(BPGM)

PGUT:

117655757(BPGM)

APRI:

131202358(BPGM)

PTEX:

113445814(BPGM)

NSS:	113419342(BPGM)

VKO:	123036382(BPGM)

PMUA:

114605263(BPGM)

PRAF:

128422059(BPGM)

ZVI:	118091307(BPGM)

HCG:	128327076(BPGM)

GJA:	107125358(BPGM)

STOW:

125435616(BPGM)

EMC:	129335707(BPGM)

XLA:	444102(bpgm.L) 444279(bpgm.S)

XTR:	549353(bpgm)

NPR:	108792024(BPGM)

RTEM:

120932636(BPGM)

BBUF:

121007153(BPGM)

BGAR:

122928322(BPGM)

MUO:	115477952(BPGM)

GSH:	117364109(BPGM)

DRE:	436903(bpgm)

SRX:	107716700 107753699

SANH:

107661509

SGH:	107576414 107590805

CAUA:

113043324 113066900

CGIB:

127946682 128014707

PTET:

122331198(bpgm)

LROH:

127156434(bpgm)

OMC:	131534269(bpgm)

PPRM:

120469137(bpgm)

RKG:	130104475(bpgm)

MAMB:

125247216(bpgm)

CIDE:

127507562

MASI:

127436034 127437701

TROS:

130551704(bpgm)

TDW:	130414431(bpgm)

MANU:

129433957(bpgm)

IPU:

108269072

IFU:	128611580(bpgm)

PHYP:

113529410(bpgm)

SMEO:

124386517(bpgm)

TFD:	113635654(bpgm)

TVC:	132856232(bpgm)

AMEX:

103029505(bpgm)

CMAO:

118806774(bpgm)

EEE:	113579716(bpgm)

CHAR:

105888494(bpgm)

TRU:	101074347(bpgm)

TFS:	130535769(bpgm)

TNG:	GSTEN00029715G001

LCO:	104940663(bpgm)

NCC:	104946798(bpgm)

TBEN:

117495010(bpgm)

CGOB:

115010217(bpgm)

PGEO:

117448569(bpgm)

GACU:

117547903(bpgm)

EMAC:

134859598(bpgm)

ELY:	117261671(bpgm)

EFO:	125887994(bpgm)

PLEP:

121950612(bpgm)

SLUC:

116038699(bpgm)

ECRA:

117949451(bpgm)

ESP:	116693930(bpgm)

PFLV:

114560377(bpgm)

GAT:	120809117(bpgm)

PPUG:

119196237(bpgm)

AFB:	129108357(bpgm)

CLUM:

117732233(bpgm)

PSWI:

130194852(bpgm)

MSAM:

119893483(bpgm)

SCHU:

122874868(bpgm)

CUD:	121515662(bpgm)

ALAT:

119023925(bpgm)

MZE:	101473870(bpgm)

ONL:	100708072(bpgm)

OAU:	116332722(bpgm)

OLA:	101172407(bpgm)

OML:	112152318(bpgm)

CSAI:

133443797(bpgm)

XMA:	102233730(bpgm)

XCO:	114133815(bpgm)

XHE:	116708874(bpgm)

PRET:

103465823(bpgm)

PFOR:

103134420(bpgm)

PLAI:

106945301(bpgm)

PMEI:

106929157(bpgm)

GAF:	122835778(bpgm)

PPRL:

129360473(bpgm)

CVG:	107095033(bpgm)

CTUL:

119799137(bpgm)

GMU:	124879263(bpgm)

NFU:	107388481(bpgm)

KMR:	108229885(bpgm)

ALIM:

106525486(bpgm)

NWH:	119416394(bpgm)

AOCE:

111567052(bpgm)

MCEP:

125015235(bpgM)

CSEM:

103380563(bpgm)

POV:	109623942(bpgm)

SSEN:

122775377(bpgm)

HHIP:

117763052(bpgm)

HSP:	118110035(bpgm)

SMAU:

118315021(bpgm)

LCF:

108888560

SDU:	111229658(bpgm)

SLAL:

111651502(bpgm)

XGL:	120793177(bpgm)

HCQ:	109530859(bpgm)

SSCV:

125970865

SBIA:

133501972 133502515(bpgm)

PEE:	133402671(bpgm)

PTAO:

133477980 133478226(bpgm)

BPEC:

110169450(bpgm)

MALB:

109951197(bpgm)

BSPL:

114857824(bpgm)

SJO:	128358446(bpgm)

SASA:

100196266(pmge) 106561646

STRU:

115152372 115197620

OTW:	112218898 112252694

OMY:	110500043 110524766

OGO:	124004499 124032856(bpgm)

ONE:	115109699(bpgm) 115115104

OKI:	109867194 109889656

OKE:	118371666 118400884

SALP:

111952995 111962766

SNH:	120053540 120066779

CCLU:

121531280 121577059

ELS:	105021856(bpgm)

SFM:	108920769 108931367

PKI:	111843107 111854613

AANG:

118219313 118232037(bpgm)

LOC:	102690514(bpgm)

PSPA:

121318552 121319494

ARUT:

117415332 117419669

PSEX:

120539400(bpgm)

LCM:	102350982(BPGM)

CMK:	103185559(bpgm)

RTP:

109927982

CPLA:

122561630(bpgm)

HOC:	132826914(bpgm)

LERI:

129707707(bpgm)

PMRN:

116944455

LRJ:	133343690(BPGM)

» show all

Reference

Authors

Ray, W.J., Jr. and Peck, E.J., Jr.

Title

Phosphomutases.

Journal

In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.

Reference

2 [PMID:5687724]

Authors

Rose ZB.

Title

The purification and properties of diphosphoglycerate mutase from human erythrocytes.

Journal

J Biol Chem 243:4810-20 (1968)

Reference

3 [PMID:6255773]

Authors

Rose ZB.

Title

The enzymology of 2,3-bisphosphoglycerate.

Journal

Adv Enzymol Relat Areas Mol Biol 51:211-53 (1980)
DOI:10.1002/9780470122969.ch5

Other DBs

ExplorEnz - The Enzyme Database:

5.4.2.4

IUBMB Enzyme Nomenclature:

5.4.2.4

ExPASy - ENZYME nomenclature database:

5.4.2.4

BRENDA, the Enzyme Database:

5.4.2.4

CAS:	37211-69-1

DBGET integrated database retrieval system