KEGG   ENZYME: 5.4.99.50
Entry
EC 5.4.99.50                Enzyme                                 
Name
friedelin synthase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, friedelin-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = friedelin [RN:R09910]
Reaction(KEGG)
R09910
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
friedelin [CPD:C08626]
Comment
The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.
History
EC 5.4.99.50 created 2011
Orthology
K21942  friedelin synthase
Reference
1  [PMID:20610397]
  Authors
Wang Z, Yeats T, Han H, Jetter R
  Title
Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids.
  Journal
J Biol Chem 285:29703-12 (2010)
DOI:10.1074/jbc.M109.098871
  Sequence
[ag:ADK35125]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.50
IUBMB Enzyme Nomenclature: 5.4.99.50
ExPASy - ENZYME nomenclature database: 5.4.99.50
BRENDA, the Enzyme Database: 5.4.99.50

  All links  
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
DNA sequence (16)   
   GenBank (8)   
   EMBL (8)   
Protein domain (5)   
   InterPro (5)   
All databases (29)   

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