KEGG   ENZYME: 5.4.99.57
Entry
EC 5.4.99.57                Enzyme                                 
Name
baruol synthase;
BARS1
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, baruol-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = baruol [RN:R09917]
Reaction(KEGG)
R09917
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
baruol [CPD:C20200]
Comment
The enzyme from Arabidopsis thaliana also produces traces of 22 other triterpenoids.
History
EC 5.4.99.57 created 2012
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K16206  baruol synthase
Genes
ATHAT4G15370(BARS1)
CSAT104718873 104732114
EUSEUTSA_v10027177mg
Reference
1  [PMID:17705488]
  Authors
Lodeiro S, Xiong Q, Wilson WK, Kolesnikova MD, Onak CS, Matsuda SP
  Title
An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis.
  Journal
J Am Chem Soc 129:11213-22 (2007)
DOI:10.1021/ja073133u
  Sequence
[ath:AT4G15370]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.57
IUBMB Enzyme Nomenclature: 5.4.99.57
ExPASy - ENZYME nomenclature database: 5.4.99.57
BRENDA, the Enzyme Database: 5.4.99.57

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