KEGG   ENZYME: 5.4.99.67
Entry
EC 5.4.99.67                Enzyme                                 
Name
4-amino-4-deoxychorismate mutase;
cmlD (gene name);
papB (gene name)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
4-amino-4-deoxychorismate pyruvatemutase
Reaction(IUBMB)
4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate [RN:R12491]
Reaction(KEGG)
R12491
Substrate
4-amino-4-deoxychorismate [CPD:C11355]
Product
4-amino-4-deoxyprephenate [CPD:C22210]
Comment
The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC 5.4.99.5, chorismate mutase.
History
EC 5.4.99.67 created 2019
Orthology
K23874  4-amino-4-deoxychorismate mutase
Genes
LBQ: CKQ53_12640
PLU: plu3564
PLUM: A4R40_17725
PAY: PAU_01183(papB)
PTT: VY86_14280
PAKH: B0X70_18040
PLUI: CE143_18065
PFS: PFLU_1772
POI: BOP93_20460
PRH: LT40_00235
PUM: HGP31_16695
PVW: HU752_023350
PSAM: HU731_009630 HU731_024785
PANH: HU763_022805
PZA: HU749_028625
VAM: C4F17_29065
BIC: LMTR13_26210
AZL: AZL_015180
ALI: AZOLI_1332
ATI: AL072_12250
AHU: A6A40_05270
AZM: DM194_04705
AZZ: DEW08_13185
AOZ: HUE56_16965
AZS: E6C72_10765
AGE: AA314_04992
HOH: Hoch_1371
MAI: MICA_333
MAN: A11S_316
BLH: BaLi_c05430
BWD: CT694_31655
LGY: T479_11125
LMOZ: LM1816_19645
LMOA: LMOATCC19117_2380
MYE: AB431_04595
MDX: BTO20_27420
MCRO: MI149_04855
MIZ: BAB75_16510
CAPP: CAPP_05545
RHA: RHA1_ro06107
RER: RER_18490
REY: O5Y_08880
REB: XU06_09115
RQI: C1M55_09360
ROP: ROP_61640
ROA: Pd630_LPD02748
RPY: Y013_04240
RBY: CEJ39_15075
RHB: NY08_973
RAV: AAT18_13975
RFA: A3L23_04226
RHS: A3Q41_04040
RHW: BFN03_03410
RRZ: CS378_03645
RHU: A3Q40_00457
RHQ: IM25_18445
RHOD: AOT96_19720
RRT: 4535765_02687(tyrA_2)
RCR: NCTC10994_00407(tyrA_1)
RTM: G4H71_16475
RKO: JWS14_33280
RGO: KYT97_09320
ROZ: CBI38_20235
RPSK: JWS13_10680
RGOR: NMQ04_11265
RHOP: D8W71_17250
REQ: REQ_23860
GOR: KTR9_2682
GTA: BCM27_14220
GRU: GCWB2_10455
GAV: C5O27_17090
GOD: GKZ92_10160
GHN: MVF96_13960
GAMI: IHQ52_13400
SVE: SVEN_0918
SPRI: SPRI_0304 SPRI_7049
SPLU: LK06_027055
SPUN: BFF78_28830
SSPO: DDQ41_19510
SSEO: D0Z67_01880
SHUN: DWB77_00730 DWB77_07152
SPRA: CP972_04210
SXN: IAG42_36285
SGOB: test1122_20490
STTN: BSL84_04775
RTE: GSU10_09890
NGV: CDO52_20870
MHAI: OHB01_07955
SACG: FDZ84_35415
APRE: CNX65_18300
SSYI: EKG83_30570
ACTY: OG774_25185
RUB: GBA63_19870
CYC: PCC7424_4585
ACY: Anacy_3719
DOU: BMF77_00659(tyrA_1)
DFS: HGD76_14690
NCN: BZZ01_09775
 » show all
Reference
1  [PMID:9044253]
  Authors
Blanc V, Gil P, Bamas-Jacques N, Lorenzon S, Zagorec M, Schleuniger J, Bisch D, Blanche F, Debussche L, Crouzet J, Thibaut D
  Title
Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-phenylalanine precursor of pristinamycin I.
  Journal
Mol Microbiol 23:191-202 (1997)
DOI:10.1046/j.1365-2958.1997.2031574.x
  Sequence
[spri:SPRI_0304 SPRI_7049]
Reference
2  [PMID:11577160]
  Authors
He J, Magarvey N, Piraee M, Vining LC
  Title
The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene.
  Journal
Microbiology 147:2817-29 (2001)
DOI:10.1099/00221287-147-10-2817
  Sequence
[sve:SVEN_0918]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.67
IUBMB Enzyme Nomenclature: 5.4.99.67
ExPASy - ENZYME nomenclature database: 5.4.99.67
BRENDA, the Enzyme Database: 5.4.99.67

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Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (102)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (101)   
Protein sequence (14)   
   UniProt (2)   
   SWISS-PROT (2)   
   RefSeq(pep) (10)   
DNA sequence (19)   
   RefSeq(nuc) (19)   
Protein domain (5)   
   InterPro (5)   
All databases (143)   

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