KEGG ENZYME: 5.5.1.16

ENZYME: 5.5.1.16

Entry

EC 5.5.1.16                 Enzyme

Name

halimadienyl-diphosphate synthase;
Rv3377c;
halimadienyl diphosphate synthase;
tuberculosinol diphosphate synthase;
halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing);
halima-5,13-dien-15-yl-diphosphate lyase (decyclizing)

Class

Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)

Sysname

halima-5,13-dien-15-yl-diphosphate lyase (ring-opening)

Reaction(IUBMB)

geranylgeranyl diphosphate = tuberculosinyl diphosphate [RN:R09715]

Reaction(KEGG)

R09715

Substrate

geranylgeranyl diphosphate [CPD:C00353]

Product

tuberculosinyl diphosphate [CPD:C19836]

Comment

Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol).

History

EC 5.5.1.16 created 2008, modified 2012

Orthology

K17811

halimadienyl-diphosphate synthase

Genes

MTU:

Rv3377c

MTV:	RVBD_3377c

MTC:

MT3487

MRA:

MRA_3417

MTF:	TBFG_13413

MTB:	TBMG_03428

MTK:	TBSG_03451

MTZ:	TBXG_003405

MTG:	MRGA327_20845

MTI:	MRGA423_21275

MTE:	CCDC5079_3124

MTUR:

CFBS_3579

MTL:	CCDC5180_3078

MTO:	MTCTRI2_3450

MTD:

UDA_3377c

MTN:	ERDMAN_3699

MTJ:	J112_18175

MTUB:

MT7199_3425

MTUC:

J113_23645

MTUE:

J114_18110

MTX:	M943_17430

MTUH:

I917_23745

MTUL:

TBHG_03315

MTUT:

HKBT1_3566

MTUU:

HKBT2_3573

MTQ:	HKBS1_3576

MBO:	BQ2027_MB3411C

MBB:

BCG_3448c

MBT:

JTY_3448

MBM:	BCGMEX_3446c

MBK:	K60_035160

MBX:

BCGT_3252

MAF:

MAF_33920

MMIC:

RN08_3725

MCE:	MCAN_34031

MCQ:	BN44_80038

MCV:	BN43_70033

MCX:	BN42_50038

MCZ:	BN45_70019

MORY:

MO_003529

MLJ:	MLAC_34850

MSHJ:

MSHI_06120

SOV:	QZH56_37145

AGRA:

AGRA3207_001027

ACIR:

OG979_21985

KUT:	JJ691_32450 JJ691_60870

RMAR:

GBA65_08765

PMET:

G4Y79_05875

» show all

Reference

1 [PMID:15719101]

Authors

Nakano C, Okamura T, Sato T, Dairi T, Hoshino T

Title

Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton.

Journal

Chem Commun (Camb) 1016-8 (2005)
DOI:10.1039/b415346d

Sequence

[mtu:Rv3377c]

Other DBs

ExplorEnz - The Enzyme Database:

5.5.1.16

IUBMB Enzyme Nomenclature:

5.5.1.16

ExPASy - ENZYME nomenclature database:

5.5.1.16

BRENDA, the Enzyme Database:

5.5.1.16

All links

Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (50)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (49)   
Protein sequence (11)   
   UniProt (10)   
   SWISS-PROT (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (4)   
   InterPro (4)   
All databases (71)   

Download RDF

DBGET integrated database retrieval system