KEGG ENZYME: 5.5.1.18

ENZYME: 5.5.1.18

Entry

EC 5.5.1.18                 Enzyme

Name

lycopene epsilon-cyclase;
CrtL-e;
LCYe;
carotenoid psi-end group lyase (decyclizing)

Class

Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)

Sysname

carotenoid psi-end group lyase (ring-opening)

Reaction(IUBMB)

carotenoid psi-end group = carotenoid epsilon-end group

Reaction(KEGG)

(other) R06960 R06963 R07840

Substrate

carotenoid psi-end group

Product

carotenoid epsilon-end group

Comment

The carotenoid lycopene has the psi-end group at both ends. When acting on one end, this enzyme forms delta-carotene. When acting on both ends, it forms epsilon-carotene.

History

EC 5.5.1.18 created 2011

Pathway

ec00906

Carotenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K06444

lycopene epsilon-cyclase

Genes

ATH:	AT5G57030(LUT2)

ALY:

9300569

CRB:

17874924

CSAT:

104733913 104761775 109124564

EUS:	EUTSA_v10013234mg

BRP:	103845139 103856778

BNA:	106371493 106387316 106418464 106436514

BOE:	106313003 106328183

RSZ:	108828178 108844261 130505650 130509272

THJ:

104811752

CPAP:

110817683

CIT:

102578059

CIC:	CICLE_v10008410mg

PVY:

116113694

MINC:

123194826

TCC:

18588358

GRA:	105769989 105793131

GHI:	107907128 107932206 107937734 107944259

GAB:	108472621 108484196

HSYR:

120131995 120166545 120209704

DZI:

111300372

EGR:

104438073

GMX:	100788180 100790686

GSJ:	114367952 114388698

PVU:	PHAVU_009G2303000

VRA:

106761979

VAR:

108331502

VUN:

114164722

VUM:

124839291

CCAJ:

109803443

APRC:

113853293

MTR:

11438775

TPRA:

123882911

CAM:

101509804

PSAT:

127136406

VVO:	131632518 131640758

LJA:	Lj6g3v1211980.1(Lj6g3v1211980.1)

ADU:

107479054

AIP:

107630506

AHF:	112738293 112790470

LANG:

109328578

PCIN:

129309864

QSA:	O6P43_002724

FVE:

101304999

RCN:

112188431

PPER:

18771479

PMUM:

103340735 107880066

PAVI:

110749277

PDUL:

117634176

MDM:

103450601

MSYL:

126606018

PXB:

103951887

ZJU:

107424069

MNT:

21409938

CSAV:

115702236

CSV:

101213753

CMO:

103498607

BHJ:

120080543

MCHA:

111021848

CMAX:

111465770 111493821

CMOS:

111444042 111450793

CPEP:

111799301 111805864

RCU:

8272573

JCU:

105637892

HBR:

110633595

MESC:

110603501

POP:

18100367

PEU:

105110117

PALZ:

118047969

JRE:

109009968

CILL:

122307924

CAVE:

132165384

QSU:

112002217

QLO:

115976084

TWL:

119995954

VVI:	100259482(LECY1)

VRI:	117905657 117907400 117925618

SLY:	544129(CrtL-e-1)

SPEN:

107007293

SOT:	102577922(LCYe)

SSTN:

125862427

SDUL:

129870770

CANN:

107840923

LBB:

132636893

NTA:	107789691(LYCe) 107830918

NSY:

104228679

NTO:

104113690

NAU:

109220074

INI:

109148024

ITR:

115998223

SIND:

105161879

OEU:

111366340

EGT:

105968091

SSPL:

121748905 121752194 121806356

SMIL:

130988432

SHIS:

125189034 125197377

APAN:

127264138

HAN:	110928451 110939526

ECAD:

122599521

LSV:

111905476

CCAV:

112501264

DCR:

108197060

CSIN:

114276622

RVL:

131320055

AEW:	130782790 130784221

BVG:

104909057

SOE:

110791410

CQI:	110683040 110712885

ATRI:

130814943

MOF:

131158118

NNU:

104600661

MING:

122063297

TSS:

122667138

PSOM:

113294804 113318755

OSA:

4324196

DOSA:

Os01t0581300-01(Os01g0581300)

OBR:

102717564

OGL:

127782304

BDI:

100821922

ATS:

109738556

TDC:

119276154

TAES:

123069994

TUA:

125543989

LPER:

127342743

LRD:

124659009

SBI:

8078213

ZMA:

100280448

SITA:

101764899

SVS:

117859306

PVIR:

120673640 120707193

PHAI:

112895026

PDA:

103723715

EGU:

105057721

MUS:

103988322

ZOF:	122002751 122007002

DCT:

110115201

PEQ:

110030128

AOF:

109835611

MSIN:

131232602

NCOL:

116246083

ATR:

18444744

SMO:	SELMODRAFT_101391 SELMODRAFT_132340

PPP:	112284858 112288918

CRE:	CHLRE_06g267600v5

VCN:	VOLCADRAFT_54924

MNG:

MNEG_1848

CSL:	COCSUDRAFT_41900

CVR:	CHLNCDRAFT_19656(LCYE)

APRO:

F751_6574

» show all

Reference

1 [PMID:11226339]

Authors

Cunningham FX Jr, Gantt E

Title

One ring or two? Determination of ring number in carotenoids by lycopene epsilon-cyclases.

Journal

Proc Natl Acad Sci U S A 98:2905-10 (2001)
DOI:10.1073/pnas.051618398

Sequence

[ath:AT5G57030]

Reference

2 [PMID:12712234]

Authors

Stickforth P, Steiger S, Hess WR, Sandmann G.

Title

A novel type of lycopene epsilon-cyclase in the marine cyanobacterium Prochlorococcus marinus MED4.

Journal

Arch Microbiol 179:409-15 (2003)
DOI:10.1007/s00203-003-0545-4

Other DBs

ExplorEnz - The Enzyme Database:

5.5.1.18

IUBMB Enzyme Nomenclature:

5.5.1.18

ExPASy - ENZYME nomenclature database:

5.5.1.18

BRENDA, the Enzyme Database:

5.5.1.18

DBGET integrated database retrieval system